{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T19:09:10Z","timestamp":1783796950226,"version":"3.55.0"},"reference-count":32,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T00:00:00Z","timestamp":1557446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18H05254, 18K04750"],"award-info":[{"award-number":["JP18H05254, 18K04750"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Entropy"],"abstract":"<jats:p>The solidification microstructures of the TiNbTaZr medium-entropy alloy and TiNbTaZrX (X = V, Mo, and W) high-entropy alloys (HEAs), including the TiNbTaZrMo bio-HEA, were investigated. Equiaxed dendrite structures were observed in the ingots that were prepared by arc melting, regardless of the position of the ingots and the alloy system. In addition, no significant difference in the solidification microstructure was observed in TiZrNbTaMo bio-HEAs between the arc-melted (AM) ingots and cold crucible levitation melted (CCLM) ingots. A cold shut was observed in the AM ingots, but not in the CCLM ingots. The interdendrite regions tended to be enriched in Ti and Zr in the TiNbTaZr MEA and TiNbTaZrX (X = V, Mo, and W) HEAs. The distribution coefficients during solidification, which were estimated by thermodynamic calculations, could explain the distribution of the constituent elements in the dendrite and interdendrite regions. The thermodynamic calculations indicated that an increase in the concentration of the low melting-temperature V (2183 K) leads to a monotonic decrease in the liquidus temperature (TL), and that increases in the concentration of high melting-temperature Mo (2896 K) and W (3695 K) lead to a monotonic increase in TL in TiNbTaZrXx (X = V, Mo, and W) (x = \u20090 \u2212 2) HEAs.<\/jats:p>","DOI":"10.3390\/e21050483","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T11:00:57Z","timestamp":1557745257000},"page":"483","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["Solidification Microstructures of the Ingots Obtained by Arc Melting and Cold Crucible Levitation Melting in TiNbTaZr Medium-Entropy Alloy and TiNbTaZrX (X = V, Mo, W) High-Entropy Alloys"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4868-0773","authenticated-orcid":false,"given":"Takeshi","family":"Nagase","sequence":"first","affiliation":[{"name":"Research Center for Ultra-High Voltage Electron Microscopy, Osaka University, 7-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Mizuuchi","sequence":"additional","affiliation":[{"name":"Osaka Research Institute of Industrial Science and Technology, 1-6-50 Morinomiya, Joto-ku, Osaka 536-8553, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8052-1698","authenticated-orcid":false,"given":"Takayoshi","family":"Nakano","sequence":"additional","affiliation":[{"name":"Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,10]]},"reference":[{"key":"ref_1","first-page":"213","article-title":"Microstructural development in equiatomic multicomponent alloys","volume":"375\u2013377","author":"Cantor","year":"2018","journal-title":"Mater. Sci. Eng. A"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/adem.200300567","article-title":"Nanostructured high-entropy alloys with multiple principal elements: Novel alloy design concepts and outcomes","volume":"6","author":"Yeh","year":"2004","journal-title":"Adv. Eng. Mater."},{"key":"ref_3","first-page":"1404","article-title":"Alloyed pleasures: Multimetallic cocktails","volume":"85","author":"Ranganathan","year":"2003","journal-title":"Curr. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/adem.200700240","article-title":"Solid-solution phase formation rules for multi-component alloys","volume":"10","author":"Zhang","year":"2008","journal-title":"Adv. Eng. Mater."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Murty, B.S., Yeh, J.-W., and Ranganathan, S. (2014). High-Entropy Alloys, Elsevier. [1st ed.].","DOI":"10.1016\/B978-0-12-800251-3.00002-X"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Gao, M.C., Yeh, J.-W., Liaw, P.K., and Zhang, Y. (2016). High-Entropy Alloys, Fundamentals and Applications, Springer. [1st ed.].","DOI":"10.1007\/978-3-319-27013-5"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s40843-017-9195-8","article-title":"Science and technology in high-entropy alloys","volume":"61","author":"Zhang","year":"2018","journal-title":"Sci. China Mater."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/j.intermet.2010.05.014","article-title":"Refractory high-entropy alloys","volume":"18","author":"Senkov","year":"2010","journal-title":"Intermetallics"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.intermet.2011.01.004","article-title":"Mechanical properties of Nb25Mo25Ta25W25 and V20Nb20Mo20Ta20W20 refractory high entropy alloys","volume":"19","author":"Senkov","year":"2011","journal-title":"Intermetallics"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1016\/j.jallcom.2011.02.171","article-title":"Microstructure and room temperature properties of a high-entropy TaNbHfZrTi alloy","volume":"509","author":"Senkov","year":"2011","journal-title":"J. Alloys Compd."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4062","DOI":"10.1007\/s10853-012-6260-2","article-title":"Microstructure and elevated temperature properties of a refractory TaNbHfZrTi alloy","volume":"47","author":"Senkov","year":"2012","journal-title":"J. Mater. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1557\/jmr.2018.153","article-title":"Development and exploration of refractory high entropy alloys\u2014A review","volume":"33","author":"Senkov","year":"2018","journal-title":"J. Mater. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1007\/s11837-015-1617-z","article-title":"Design of refractory high-entropy alloys","volume":"67","author":"Gao","year":"2015","journal-title":"JOM"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.scriptamat.2016.10.028","article-title":"Novel TiNbTaZrMo high-entropy alloys for metallic biomaterials","volume":"129","author":"Todai","year":"2017","journal-title":"Scr. Mater."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.msec.2016.12.057","article-title":"TiZrNbTaMo high-entropy alloy designed for orthopedic implants: As-cast microstructure and mechanical properties","volume":"73","author":"Wang","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jallcom.2018.04.082","article-title":"Microstructure of equiatomic and non-equiatomic Ti-Nb-Ta-Zr-Mo high-entropy alloys for metallic biomaterials","volume":"753","author":"Nagase","year":"2018","journal-title":"J. Alloys Compd."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"78","DOI":"10.2320\/materia.58.78","article-title":"Solidification Microstructure of High Entropy Alloys Composed With 4 Group (Ti, Zr, Hf), 5 Group (V, Nb, Ta), and 6 Group (Cr, Mo, W)","volume":"58","author":"Nagase","year":"2019","journal-title":"Materia Japan"},{"key":"ref_18","unstructured":"Nagase, T. in preparation."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.intermet.2018.07.008","article-title":"A novel quaternary equiatomic Ti-Zr-Nb-Ta medium entropy alloy (MEA)","volume":"101","author":"Nguyen","year":"2018","journal-title":"Intermetallics"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Yao, H.W., Qiao, J.-W., Gao, M.C., Hawk, J.A., Ma, S.-G., and Zhou, H. (2016). MoNbTaV Medium-entropy alloy. Entropy, 18.","DOI":"10.3390\/e18050189"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.jallcom.2016.11.188","article-title":"Mechanical properties of refractory high-entropy alloys: Experiments and modeling","volume":"696","author":"Yao","year":"2017","journal-title":"J. Alloys Compd."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.matchemphys.2011.11.021","article-title":"Prediction of high-entropy stabilized solid-solution in multi-component alloys","volume":"132","author":"Yang","year":"2012","journal-title":"Mater. Chem. Phys."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"103505","DOI":"10.1063\/1.3587228","article-title":"Effect of valence electron concentration on stability of fcc or bcc phase in high entropy alloys","volume":"109","author":"Guo","year":"2011","journal-title":"J. Appl. Phys."},{"key":"ref_24","unstructured":"(2018, November 14). Mitsuwa Chemical Co., Ltd., Japan. Available online: http:\/\/www.eonet.ne.jp\/~mitsuwa-chem\/index.html."},{"key":"ref_25","unstructured":"(2018, November 14). Rare Metallic Co., Ltd., Japan. Available online: http:\/\/rare-meta.co.jp."},{"key":"ref_26","unstructured":"(2018, November 14). The Nilaco Co., Ltd., Japan. Available online: http:\/\/nilaco.jp\/en\/index.php."},{"key":"ref_27","first-page":"30","article-title":"The Effect of Cooling Rate on the Dendrite Spacing in Splta-Cooled Aluminium Alloys","volume":"96","author":"Matyja","year":"1968","journal-title":"J. Inst Metals"},{"key":"ref_28","first-page":"131","article-title":"Formation and Applications of Rapidly Quenched Metals","volume":"24","author":"Naka","year":"1998","journal-title":"J. High Temp. Soc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.jallcom.2017.12.138","article-title":"Microstructure of Ti-Ag immiscible alloys with metastable liquid phase separation","volume":"738","author":"Nagase","year":"2018","journal-title":"J. Alloys Compd."},{"key":"ref_30","unstructured":"Bale, C.W., Pelton, A.D., Thompson, W.T., and Eriksson, G. (2018, November 10). FactSage, Ecole Polytechnique, Montreal (2001). Available online: http:\/\/www.crct.polymtl.ca."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2320\/matertrans.F-M2017851","article-title":"Solidification microstructure analysis of AlCoCrFeNi2.1 eutectic high entropy alloy ingots","volume":"59","author":"Nagase","year":"2018","journal-title":"Mater. Trans."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF01349680","article-title":"Die Konstitution der Mischkristalle und die Raumfullung der Atome","volume":"5","author":"Vegard","year":"1921","journal-title":"Zeitschrift fur Physik"}],"container-title":["Entropy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1099-4300\/21\/5\/483\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:50:59Z","timestamp":1760187059000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1099-4300\/21\/5\/483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,10]]},"references-count":32,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,5]]}},"alternative-id":["e21050483"],"URL":"https:\/\/doi.org\/10.3390\/e21050483","relation":{},"ISSN":["1099-4300"],"issn-type":[{"value":"1099-4300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,10]]}}}