{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T04:06:01Z","timestamp":1781496361309,"version":"3.54.1"},"reference-count":45,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61961160705"],"award-info":[{"award-number":["61961160705"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U19A2082"],"award-info":[{"award-number":["U19A2082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61901077"],"award-info":[{"award-number":["61901077"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Science and Technology Program","award":["2018JY0526"],"award-info":[{"award-number":["2018JY0526"]}]},{"name":"Young Scholars Reserve Talents program of Xihua University","award":["2019"],"award-info":[{"award-number":["2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Entropy"],"abstract":"<jats:p>The accurate identification of an attention deficit hyperactivity disorder (ADHD) subject has remained a challenge for both neuroscience research and clinical diagnosis. Unfortunately, the traditional methods concerning the classification model and feature extraction usually depend on the single-channel model and static measurements (i.e., functional connectivity, FC) in the small, homogenous single-site dataset, which is limited and may cause the loss of intrinsic information in functional MRI (fMRI). In this study, we proposed a new two-stage network structure by combing a separated channel convolutional neural network (SC-CNN) with an attention-based network (SC-CNN-attention) to discriminate ADHD and healthy controls on a large-scale multi-site database (5 sites and n = 1019). To utilize both intrinsic temporal feature and the interactions of temporal dependent in whole-brain resting-state fMRI, in the first stage of our proposed network structure, a SC- CNN is used to learn the temporal feature of each brain region, and an attention network in the second stage is adopted to capture temporal dependent features among regions and extract fusion features. Using a \u201cleave-one-site-out\u201d cross-validation framework, our proposed method obtained a mean classification accuracy of 68.6% on five different sites, which is higher than those reported in previous studies. The classification results demonstrate that our proposed network is robust to data variants and is also replicated across sites. The combination of the SC-CNN with the attention network is powerful to capture the intrinsic fMRI information to discriminate ADHD across multi-site resting-state fMRI data. <\/jats:p>","DOI":"10.3390\/e22080893","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T08:28:35Z","timestamp":1597393715000},"page":"893","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Separated Channel Attention Convolutional Neural Network (SC-CNN-Attention) to Identify ADHD in Multi-Site Rs-fMRI Dataset"],"prefix":"10.3390","volume":"22","author":[{"given":"Tao","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Science, Xihua University, Chengdu 610039, China"},{"name":"School of Life Science and Technology, Center for Information in BioMedicine, University of Electronic Science and Technology of China, Chengdu 611731, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1954-6113","authenticated-orcid":false,"given":"Cunbo","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Center for Information in BioMedicine, University of Electronic Science and Technology of China, Chengdu 611731, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Bioinformatics, Chongqing University of Posts and Telecommunications, Chongqing 400065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueheng","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Center for Information in BioMedicine, University of Electronic Science and Technology of China, Chengdu 611731, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Kang","sequence":"additional","affiliation":[{"name":"Sichuan 81 Rehabilitation Centre, Chengdu University of TCM, Chengdu 611137, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Center for Information in BioMedicine, University of Electronic Science and Technology of China, Chengdu 611731, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fali","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Center for Information in BioMedicine, University of Electronic Science and Technology of China, Chengdu 611731, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyang","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Center for Information in BioMedicine, University of Electronic Science and Technology of China, Chengdu 611731, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dezhong","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Center for Information in BioMedicine, University of Electronic Science and Technology of China, Chengdu 611731, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharat","family":"Biswal","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Center for Information in BioMedicine, University of Electronic Science and Technology of China, Chengdu 611731, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Center for Information in BioMedicine, University of Electronic Science and Technology of China, Chengdu 611731, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1037\/0033-2909.121.1.65","article-title":"Behavioral inhibition, sustained attention, and executive functions: Constructing a unifying theory of ADHD","volume":"121","author":"Barkley","year":"1997","journal-title":"Psychol. 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