{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T22:15:32Z","timestamp":1776032132894,"version":"3.50.1"},"reference-count":32,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2017JM8003"],"award-info":[{"award-number":["2017JM8003"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Special Science and Technology Project of Shaanxi Education Department","award":["17JK0368"],"award-info":[{"award-number":["17JK0368"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Entropy"],"abstract":"<jats:p>Local vibration has shown promise in improving skin blood flow (SBF). However, there is no consensus on the selection of the best vibration frequency. An important reason may be that previous studies utilized time- and frequency-domain parameters to characterize vibration-induced SBF responses. These parameters are unable to characterize the structural features of the SBF response to local vibrations, thus contributing to the inconsistent findings seen in vibration research. The objective of this study was to provide evidence that nonlinear dynamics of SBF responses would be an important aspect for assessing the effect of local vibration on SBF. Local vibrations at 100 Hz, 35 Hz, and 0 Hz (sham vibration) with an amplitude of 1 mm were randomly applied to the right first metatarsal head of 12 healthy participants for 10 min. SBF at the same site was measured for 10 min before and after local vibration. The degree of regularity of SBF was quantified using a multiscale sample entropy algorithm. The results showed that 100 Hz vibration significantly increased multiscale regularity of SBF but 35 Hz and 0 Hz (sham vibration) did not. The significant increase of regularity of SBF after 100 Hz vibration was mainly attributed to increased regularity of SBF oscillations within the frequency interval at 0.0095\u20130.15 Hz. These findings support the use of multiscale regularity to assess effectiveness of local vibration on improving skin blood flow.<\/jats:p>","DOI":"10.3390\/e22111288","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T08:44:02Z","timestamp":1605257042000},"page":"1288","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of Different Local Vibration Frequencies on the Multiscale Regularity of Plantar Skin Blood Flow"],"prefix":"10.3390","volume":"22","author":[{"given":"Fuyuan","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Xi\u2019an Technological University, Xi\u2019an 710021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Rehabilitation Engineering Laboratory, Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Champaign, IL 61820, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"Zhou","sequence":"additional","affiliation":[{"name":"Rehabilitation Engineering Laboratory, Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Champaign, IL 61820, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanni","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannette","family":"Elliott","sequence":"additional","affiliation":[{"name":"Disability Resources and Educational Services, University of Illinois at Urbana-Champaign, Champaign, IL 61820, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7149-4034","authenticated-orcid":false,"given":"Yih-Kuen","family":"Jan","sequence":"additional","affiliation":[{"name":"Rehabilitation Engineering Laboratory, Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Champaign, IL 61820, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1056\/NEJMra1615439","article-title":"Diabetic Foot Ulcers and Their Recurrence","volume":"376","author":"Ingelfinger","year":"2017","journal-title":"N. 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