{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T15:29:32Z","timestamp":1772206172683,"version":"3.50.1"},"reference-count":60,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Entropy"],"abstract":"<jats:p>Background: The detection of driver fatigue as a cause of sleepiness is a key technology capable of preventing fatal accidents. This research uses a fatigue-related sleepiness detection algorithm based on the analysis of the pulse rate variability generated by the heartbeat and validates the proposed method by comparing it with an objective indicator of sleepiness (PERCLOS). Methods: changes in alert conditions affect the autonomic nervous system (ANS) and therefore heart rate variability (HRV), modulated in the form of a wave and monitored to detect long-term changes in the driver\u2019s condition using real-time control. Results: the performance of the algorithm was evaluated through an experiment carried out in a road vehicle. In this experiment, data was recorded by three participants during different driving sessions and their conditions of fatigue and sleepiness were documented on both a subjective and objective basis. The validation of the results through PERCLOS showed a 63% adherence to the experimental findings. Conclusions: the present study confirms the possibility of continuously monitoring the driver\u2019s status through the detection of the activation\/deactivation states of the ANS based on HRV. The proposed method can help prevent accidents caused by drowsiness while driving.<\/jats:p>","DOI":"10.3390\/e23020135","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T11:49:40Z","timestamp":1611229780000},"page":"135","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["On-Road Detection of Driver Fatigue and Drowsiness during Medium-Distance Journeys"],"prefix":"10.3390","volume":"23","author":[{"given":"Luca","family":"Salvati","sequence":"first","affiliation":[{"name":"Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2886-0032","authenticated-orcid":false,"given":"Matteo","family":"d\u2019Amore","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Fiorentino","sequence":"additional","affiliation":[{"name":"Pomigliano Technical Center, Fiat Chrysler Automobiles, Via Ex Aeroporto, 80038 Pomigliano d\u2019Arco (NA), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arcangelo","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Sena","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6545-4589","authenticated-orcid":false,"given":"Francesco","family":"Villecco","sequence":"additional","affiliation":[{"name":"Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"ref_1","unstructured":"(2021, January 19). 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