{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T02:13:10Z","timestamp":1769047990938,"version":"3.49.0"},"reference-count":49,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Higher Education, Poland","award":["SMGR.RN.20.096"],"award-info":[{"award-number":["SMGR.RN.20.096"]}]},{"name":"Ministry of Science and Higher Education, Poland","award":["SMGR.RN.20.222.628"],"award-info":[{"award-number":["SMGR.RN.20.222.628"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Entropy"],"abstract":"<jats:p>The study of drugs diffusion through different biological membranes constitutes an essential step in the development of new pharmaceuticals. In this study, the method based on the monolayer cell culture of CHO-K1 cells has been developed in order to emulate the epithelial cells barrier in permeability studies by laser interferometry. Laser interferometry was employed for the experimental analysis of nickel(II) and cobalt(II) complexes with 1-allylimidazole or their chlorides\u2019 diffusion through eukaryotic cell monolayers. The amount (mol) of nickel(II) and cobalt(II) chlorides transported through the monolayer was greater than that of metals complexed with 1-allylimidazole by 4.34-fold and 1.45-fold, respectively, after 60 min. Thus, laser interferometry can be used for the quantitative analysis of the transport of compounds through eukaryotic cell monolayers, and the resulting parameters can be used to formulate a mathematical description of this process.<\/jats:p>","DOI":"10.3390\/e23030360","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T11:48:22Z","timestamp":1615981702000},"page":"360","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Experimental and Theoretical Analysis of Metal Complex Diffusion through Cell Monolayer"],"prefix":"10.3390","volume":"23","author":[{"given":"Katarzyna","family":"Ga\u0142czy\u0144ska","sequence":"first","affiliation":[{"name":"Institute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaros\u0142aw","family":"Rachuna","sequence":"additional","affiliation":[{"name":"Institute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karol","family":"Ciepluch","sequence":"additional","affiliation":[{"name":"Institute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Kowalska","sequence":"additional","affiliation":[{"name":"Institute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0107-4493","authenticated-orcid":false,"given":"S\u0142awomir","family":"W\u0105sik","sequence":"additional","affiliation":[{"name":"Institute of Physics, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5710-2970","authenticated-orcid":false,"given":"Tadeusz","family":"Koszto\u0142owicz","sequence":"additional","affiliation":[{"name":"Institute of Physics, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna D.","family":"Lewandowska","sequence":"additional","affiliation":[{"name":"Department of Radiological Informatics and Statistics, Medical University of Gda\u0144sk, Tuwima 15, 80-210 Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Semaniak","sequence":"additional","affiliation":[{"name":"Institute of Physics, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krystyna","family":"Kurdziel","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9712-9286","authenticated-orcid":false,"given":"Micha\u0142","family":"Arabski","sequence":"additional","affiliation":[{"name":"Institute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-1-4939-2272-7_3","article-title":"Getting Across the Cell Membrane: An Overview for Small Molecules, Peptides, and Proteins","volume":"1266","author":"Yang","year":"2015","journal-title":"Site-Specif. 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