{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:25:04Z","timestamp":1769124304392,"version":"3.49.0"},"reference-count":48,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T00:00:00Z","timestamp":1635638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Russian Foundation for Basic Research and Administration of the Krasnodar Region","award":["19-44-230026"],"award-info":[{"award-number":["19-44-230026"]}]},{"name":"state assignment of the SSC RAS","award":["AAAA-A19-119040390083-6"],"award-info":[{"award-number":["AAAA-A19-119040390083-6"]}]},{"name":"Kuban Scientific Foundation","award":["MFI-20.1-36\/20"],"award-info":[{"award-number":["MFI-20.1-36\/20"]}]},{"name":"Program of Fundamental Research for State Academies for years 2013\u20132020","award":["01201363818"],"award-info":[{"award-number":["01201363818"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Entropy"],"abstract":"<jats:p>Fluctuations in viscosity within the cell nucleus have wide limits. When a DNA molecule passes from the region of high viscosity values to the region of low values, open states, denaturation bubbles, and unweaving of DNA strands can occur. Stabilization of the molecule is provided by energy dissipation\u2014dissipation due to interaction with the environment. Separate sections of a DNA molecule in a twisted state can experience supercoiling stress, which, among other things, is due to complex entropic effects caused by interaction with a solvent. In this work, based on the numerical solution of a mechanical mathematical model for the interferon alpha 17 gene and a fragment of the Drosophila gene, an analysis of the external environment viscosity influence on the dynamics of the DNA molecule and its stability was carried out. It has been shown that an increase in viscosity leads to a rapid stabilization of the angular vibrations of nitrogenous bases, while a decrease in viscosity changes the dynamics of DNA: the rate of change in the angular deviations of nitrogenous bases increases and the angular deformations of the DNA strands increase at each moment of time. These processes lead to DNA instability, which increases with time. Thus, the paper considers the influence of the external environment viscosity on the dissipation of the DNA nitrogenous bases\u2019 vibrational motion energy. Additionally, the study on the basis of the described model of the molecular dynamics of physiological processes at different indicators of the rheological behavior of nucleoplasm will allow a deeper understanding of the processes of nonequilibrium physics of an active substance in a living cell to be obtained.<\/jats:p>","DOI":"10.3390\/e23111446","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T22:21:08Z","timestamp":1635805268000},"page":"1446","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Influence of Environmental Parameters on the Stability of the DNA Molecule"],"prefix":"10.3390","volume":"23","author":[{"given":"Alexander","family":"Svidlov","sequence":"first","affiliation":[{"name":"Department of Radiophysics and Nanothechnology, Kuban State University, 350040 Krasnodar, Russia"},{"name":"Federal Research Center the Southern Scientific Center of the Russian Academy of Sciences, 344006 Rostov-on-Don, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail","family":"Drobotenko","sequence":"additional","affiliation":[{"name":"Department of Radiophysics and Nanothechnology, Kuban State University, 350040 Krasnodar, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2262-4549","authenticated-orcid":false,"given":"Alexander","family":"Basov","sequence":"additional","affiliation":[{"name":"Department of Radiophysics and Nanothechnology, Kuban State University, 350040 Krasnodar, Russia"},{"name":"Department of Fundamental and Clinical Biochemistry, Kuban State Medical University, 350063 Krasnodar, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugeny","family":"Gerasimenko","sequence":"additional","affiliation":[{"name":"Department of Technology of Fats, Cosmetics, Commodity Science, Processes and Devices Kuban State Technological University, 350072 Krasnodar, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Elkina","sequence":"additional","affiliation":[{"name":"Department of Radiophysics and Nanothechnology, Kuban State University, 350040 Krasnodar, Russia"},{"name":"Federal Research Center the Southern Scientific Center of the Russian Academy of Sciences, 344006 Rostov-on-Don, Russia"},{"name":"Department of Technology of Fats, Cosmetics, Commodity Science, Processes and Devices Kuban State Technological University, 350072 Krasnodar, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail","family":"Baryshev","sequence":"additional","affiliation":[{"name":"Department of Radiophysics and Nanothechnology, Kuban State University, 350040 Krasnodar, Russia"},{"name":"Federal Research Center the Southern Scientific Center of the Russian Academy of Sciences, 344006 Rostov-on-Don, Russia"},{"name":"Department of Technology of Fats, Cosmetics, Commodity Science, Processes and Devices Kuban State Technological University, 350072 Krasnodar, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6976-1655","authenticated-orcid":false,"given":"Yury","family":"Nechipurenko","sequence":"additional","affiliation":[{"name":"Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2618-5376","authenticated-orcid":false,"given":"Stepan","family":"Dzhimak","sequence":"additional","affiliation":[{"name":"Department of Radiophysics and Nanothechnology, Kuban State University, 350040 Krasnodar, Russia"},{"name":"Federal Research Center the Southern Scientific Center of the Russian Academy of Sciences, 344006 Rostov-on-Don, Russia"},{"name":"Department of Technology of Fats, Cosmetics, Commodity Science, Processes and Devices Kuban State Technological University, 350072 Krasnodar, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s12551-018-0399-2","article-title":"Effect of water and ionic liquids on biomolecules","volume":"10","author":"Saha","year":"2018","journal-title":"Biophys. 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