{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T06:07:25Z","timestamp":1762063645602,"version":"build-2065373602"},"reference-count":64,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundamental Research in the Russian Federation for the 2021\u20132030 period","award":["121052600299-1"],"award-info":[{"award-number":["121052600299-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Entropy"],"abstract":"<jats:p>The study of hemoglobin oxygenation, starting from the classical works of Hill, has laid the foundation for molecular biophysics. The cooperative nature of oxygen binding to hemoglobin has been variously described in different models. In the Adair model, which better fits the experimental data, the constants of oxygen binding at various stages differ. However, the physical meaning of the parameters in this model remains unclear. In this work, we applied Hill\u2019s approach, extending its interpretation; we obtained a good agreement between the theory and the experiment. The equation in which the Hill coefficient is modulated by the Lorentz distribution for oxygen partial pressure approximates the experimental data better than not only the classical Hill equation, but also the Adair equation.<\/jats:p>","DOI":"10.3390\/e24091214","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T21:25:18Z","timestamp":1661894718000},"page":"1214","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A New Model of Hemoglobin Oxygenation"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2570-7331","authenticated-orcid":false,"given":"Igor A.","family":"Lavrinenko","sequence":"first","affiliation":[{"name":"Department of Human and Animal Physiology, Voronezh State University, Universitetskaya Sq. 1, 394018 Voronezh, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gennady A.","family":"Vashanov","sequence":"additional","affiliation":[{"name":"Department of Human and Animal Physiology, Voronezh State University, Universitetskaya Sq. 1, 394018 Voronezh, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4406-444X","authenticated-orcid":false,"given":"Jos\u00e9 L.","family":"Hern\u00e1ndez C\u00e1ceres","sequence":"additional","affiliation":[{"name":"Cuban Neuroscience Center, 15202 Avenida 25, Playa, La Habana 11600, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1853-4671","authenticated-orcid":false,"given":"Anatoly S.","family":"Buchelnikov","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Biophysics, Sevastopol State University, Universitetskaya Str. 33, 299053 Sevastopol, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6976-1655","authenticated-orcid":false,"given":"Yury D.","family":"Nechipurenko","sequence":"additional","affiliation":[{"name":"Laboratory of DNA-Protein Interactions, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilova Str. 32, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1110\/ps.03259908","article-title":"Allostery and cooperativity revisited","volume":"17","author":"Cui","year":"2008","journal-title":"Protein Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6323","DOI":"10.1021\/acs.chemrev.5b00541","article-title":"Solution NMR Spectroscopy for the Study of Enzyme Allostery","volume":"116","author":"Lisi","year":"2016","journal-title":"Chem. 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