{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T14:24:08Z","timestamp":1774448648097,"version":"3.50.1"},"reference-count":44,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62173291"],"award-info":[{"award-number":["62173291"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["202250701010046"],"award-info":[{"award-number":["202250701010046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hebei Key Laboratory Project","award":["62173291"],"award-info":[{"award-number":["62173291"]}]},{"name":"Hebei Key Laboratory Project","award":["202250701010046"],"award-info":[{"award-number":["202250701010046"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Entropy"],"abstract":"<jats:p>So far, most articles using the multivariate multi-scale entropy algorithm mainly use algorithms to analyze the multivariable signal complexity without clearly describing what characteristics of signals these algorithms measure and what factors affect these algorithms. This paper analyzes six commonly used multivariate multi-scale entropy algorithms from a new perspective. It clarifies for the first time what characteristics of signals these algorithms measure and which factors affect them. It also studies which algorithm is more suitable for analyzing mild cognitive impairment (MCI) electroencephalograph (EEG) signals. The simulation results show that the multivariate multi-scale sample entropy (mvMSE), multivariate multi-scale fuzzy entropy (mvMFE), and refined composite multivariate multi-scale fuzzy entropy (RCmvMFE) algorithms can measure intra- and inter-channel correlation and multivariable signal complexity. In the joint analysis of coupling and complexity, they all decrease with the decrease in signal complexity and coupling strength, highlighting their advantages in processing related multi-channel signals, which is a discovery in the simulation. Among them, the RCmvMFE algorithm can better distinguish different complexity signals and correlations between channels. It also performs well in anti-noise and length analysis of multi-channel data simultaneously. Therefore, we use the RCmvMFE algorithm to analyze EEG signals from twenty subjects (eight control subjects and twelve MCI subjects). The results show that the MCI group had lower entropy than the control group on the short scale and the opposite on the long scale. Moreover, frontal entropy correlates significantly positively with the Montreal Cognitive Assessment score and Auditory Verbal Learning Test delayed recall score on the short scale.<\/jats:p>","DOI":"10.3390\/e25030396","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T02:57:38Z","timestamp":1677034658000},"page":"396","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Which Multivariate Multi-Scale Entropy Algorithm Is More Suitable for Analyzing the EEG Characteristics of Mild Cognitive Impairment?"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9549-0177","authenticated-orcid":false,"given":"Jing","family":"Liu","sequence":"first","affiliation":[{"name":"Hebei Key Laboratory of Information Transmission and Signal Processing, School of Information Science and Engineering, Yanshan University, Qinhuangdao 066004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huibin","family":"Lu","sequence":"additional","affiliation":[{"name":"Hebei Key Laboratory of Information Transmission and Signal Processing, School of Information Science and Engineering, Yanshan University, Qinhuangdao 066004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuru","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hebei Key Laboratory of Information Transmission and Signal Processing, School of Information Science and Engineering, Yanshan University, Qinhuangdao 066004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1359-5130","authenticated-orcid":false,"given":"Xiaoli","family":"Li","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Neurology Department, Chinese People\u2019s Liberation Army Rocket Force Characteristic Medical Center, Beijing 100088, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimin","family":"Yin","sequence":"additional","affiliation":[{"name":"Neurology Department, Chinese People\u2019s Liberation Army Rocket Force Characteristic Medical Center, Beijing 100088, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Cui","sequence":"additional","affiliation":[{"name":"Hebei Key Laboratory of Information Transmission and Signal Processing, School of Information Science and Engineering, Yanshan University, Qinhuangdao 066004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.neuroimage.2019.06.058","article-title":"Neurovascular decoupling in type 2 diabetes mellitus without mild cognitive impairment: Potential biomarker for early cognitive impairment","volume":"200","author":"Yu","year":"2019","journal-title":"Neuroimage"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s00592-020-01648-9","article-title":"The prevalence of mild cognitive impairment in type 2 diabetes mellitus patients: A systematic review and meta-analysis","volume":"58","author":"You","year":"2021","journal-title":"Acta Diabetol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1093\/schbul\/sbaa033","article-title":"Revisiting the Potential of EEG Neurofeedback for Patients With Schizophrenia","volume":"46","author":"Singh","year":"2020","journal-title":"Schizophr. 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