{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:10:14Z","timestamp":1784646614091,"version":"3.55.0"},"reference-count":116,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European High Performance Computing Joint Undertaking (JU)","award":["101093261"],"award-info":[{"award-number":["101093261"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Entropy"],"abstract":"<jats:p>Noisy Intermediate-Scale Quantum (NISQ) systems and associated programming interfaces make it possible to explore and investigate the design and development of quantum computing techniques for Machine Learning (ML) applications. Among the most recent quantum ML approaches, Quantum Neural Networks (QNN) emerged as an important tool for data analysis. With the QNN advent, higher-level programming interfaces for QNN have been developed. In this paper, we survey the current state-of-the-art high-level programming approaches for QNN development. We discuss target architectures, critical QNN algorithmic components, such as the hybrid workflow of Quantum Annealers and Parametrized Quantum Circuits, QNN architectures, optimizers, gradient calculations, and applications. Finally, we overview the existing programming QNN frameworks, their software architecture, and associated quantum simulators.<\/jats:p>","DOI":"10.3390\/e25040694","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T04:53:59Z","timestamp":1681966439000},"page":"694","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Programming Quantum Neural Networks on NISQ Systems: An Overview of Technologies and Methodologies"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0639-0639","authenticated-orcid":false,"given":"Stefano","family":"Markidis","sequence":"first","affiliation":[{"name":"KTH Royal Institute of Technology, 114 28 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Nielsen, M.A., and Chuang, I. 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