{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:14:26Z","timestamp":1782173666149,"version":"3.54.5"},"reference-count":44,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T00:00:00Z","timestamp":1689379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Program of Fundamental Research in the Russian Federation","award":["121052600299-1"],"award-info":[{"award-number":["121052600299-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Entropy"],"abstract":"<jats:p>The problem of the degradation and aging of bioorganisms is herein considered from the viewpoint of statistical physics. Two typical timescales in biological systems\u2014the time of metabolic processes and the time of the life cycle\u2014are used. A kinetic equation describing the small timescales of the systems\u2019 characteristic processes in is proposed. Maintaining a biosystem in a time-stable state requires a constant inflow of negative entropy (negentropy). Ratios are proposed to evaluate the aging and degradation of systems in terms of entropy. As an example, the aging of the epithelium is studied. The connection of our approach to the information theory of aging is discussed, as well as theoretical constructions related to the concept of cooperon and its changing with time.<\/jats:p>","DOI":"10.3390\/e25071067","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:35:04Z","timestamp":1689554104000},"page":"1067","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Degradation and Aging of Biological Systems as a Process of Information Loss and Entropy Increase"],"prefix":"10.3390","volume":"25","author":[{"given":"Vladimir V.","family":"Aristov","sequence":"first","affiliation":[{"name":"Federal Research Center \u201cComputer Science and Control\u201d of Russian Academy of Sciences, Vavilova Str. 40, 119333 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey V.","family":"Karnaukhov","sequence":"additional","affiliation":[{"name":"Institute of Cell Biophysics of the Russian Academy of Sciences, Moskovskaya obl., Institutskaya Str. 3, 142290 Pushchino, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1853-4671","authenticated-orcid":false,"given":"Anatoly S.","family":"Buchelnikov","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Biophysics, Sevastopol State University, Universitetskaya Str. 33, 299053 Sevastopol, Russia"},{"name":"Laboratory of DNA\u2013Protein Interactions, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Vavilova Str. 32, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir F.","family":"Levchenko","sequence":"additional","affiliation":[{"name":"Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Russian Federation, Thorez 44, 194223 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6976-1655","authenticated-orcid":false,"given":"Yury D.","family":"Nechipurenko","sequence":"additional","affiliation":[{"name":"Laboratory of DNA\u2013Protein Interactions, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Vavilova Str. 32, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,15]]},"reference":[{"key":"ref_1","unstructured":"Kanungo, M.S. 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