{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:16:46Z","timestamp":1777501006425,"version":"3.51.4"},"reference-count":135,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of General Medical Sciences of the National Institutes of Health","award":["R01-GM103894"],"award-info":[{"award-number":["R01-GM103894"]}]},{"name":"National Institute of General Medical Sciences of the National Institutes of Health","award":["T32-GM103730"],"award-info":[{"award-number":["T32-GM103730"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Entropy"],"abstract":"<jats:p>Time and space are fundamental elements that permeate the fabric of nature, and their significance in relation to neural activity and consciousness remains a compelling yet unexplored area of research. The Temporospatial Theory of Consciousness (TTC) provides a framework that links time, space, neural activity, and consciousness, shedding light on the intricate relationships among these dimensions. In this review, I revisit the fundamental concepts and mechanisms proposed by the TTC, with a particular focus on the central concept of temporospatial nestedness. I propose an extension of temporospatial nestedness by incorporating the nested relationship between the temporal circuit and functional geometry of the brain. To further unravel the complexities of temporospatial nestedness, future research directions should emphasize the characterization of functional geometry and the temporal circuit across multiple spatial and temporal scales. Investigating the links between these scales will yield a more comprehensive understanding of how spatial organization and temporal dynamics contribute to conscious states. This integrative approach holds the potential to uncover novel insights into the neural basis of consciousness and reshape our understanding of the world\u2013brain dynamic.<\/jats:p>","DOI":"10.3390\/e25071074","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T01:31:32Z","timestamp":1689643892000},"page":"1074","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Temporospatial Nestedness in Consciousness: An Updated Perspective on the Temporospatial Theory of Consciousness"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5949-0206","authenticated-orcid":false,"given":"Zirui","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA"},{"name":"Center for Consciousness Science, University of Michigan Medical School, Ann Arbor, MI 48109, USA"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.tics.2020.07.006","article-title":"Cellular Mechanisms of Conscious Processing","volume":"24","author":"Aru","year":"2020","journal-title":"Trends Cogn. 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