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The theory of active inference proposes that the developmental organization of sentient systems reflects general processes of informatic self-evidencing, through the minimization of free energy. We interpret this theory to imply that the mind may be described in information terms that are not dependent on a specific physical substrate. At a certain level of complexity, self-evidencing of living (self-organizing) information systems becomes hierarchical and reentrant, such that effective consciousness emerges as the consequence of a good regulator. We propose that these principles imply that an adequate reconstruction of the computational dynamics of an individual human brain\/mind is possible with sufficient neuromorphic computational emulation.<\/jats:p>","DOI":"10.3390\/e26090759","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T02:34:06Z","timestamp":1725503646000},"page":"759","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of a Personal Neuromorphic Emulation"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8304-7829","authenticated-orcid":false,"given":"Don M.","family":"Tucker","sequence":"first","affiliation":[{"name":"The Brain Electrophysiological Laboratory Company, Eugene, OR 97403, USA"},{"name":"Department of Psychology, University of Oregon, Eugene, OR 97403, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phan","family":"Luu","sequence":"additional","affiliation":[{"name":"The Brain Electrophysiological Laboratory Company, Eugene, OR 97403, USA"},{"name":"Department of Psychology, University of Oregon, Eugene, OR 97403, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1037\/h0042519","article-title":"The Perceptron: A Probabilistic Model for Information Storage and Organization in the Brain","volume":"65","author":"Rosenblatt","year":"1958","journal-title":"Psychol. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1037\/0033-295X.87.1.1","article-title":"How does a brain build a cognitive code?","volume":"87","author":"Grossberg","year":"1980","journal-title":"Psychol. Rev."},{"key":"ref_3","unstructured":"Minsky, M., and Papert, S. (1969). An Introduction to Computational Geometry, Science Press."},{"key":"ref_4","unstructured":"Shaie, K.W., and Laughton, M.P. (1998). Aging and the Plasticity of the Self. Annual Review of Gerontology and Geriatrics, Vol 17: Focus on Emotion and Adult Development, Springer."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Rumelhart, D.E., and McClelland, J.L. (1986). Parallel Distributed Processing: Explorations in the Microstructure of Cognition, MIT Press. Volume I: Foundations.","DOI":"10.7551\/mitpress\/5236.001.0001"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1162\/neco.1995.7.5.889","article-title":"The helmholtz machine","volume":"7","author":"Dayan","year":"1995","journal-title":"Neural Comput."},{"key":"ref_7","unstructured":"Friston, K. (2019). A free energy principle for a particular physics. arXiv."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Changeux, J.-P. (2002). The Physiology of Truth: Neuroscience and Human Knowledge, Harvard University Press.","DOI":"10.4159\/9780674029415"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Tucker, D.M., and Luu, P. (2012). Cognition and Neural Development, Oxford University Press.","DOI":"10.1093\/acprof:oso\/9780199838523.001.0001"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Johnson, M., and Tucker, D.M. (2021). Out of the Cave: The Natural Philosophy of Mind and Knowing, MIT Press.","DOI":"10.7551\/mitpress\/14016.001.0001"},{"key":"ref_11","unstructured":"Schrodinger, E. (1944). What is Life? The Physical Aspect of the Living Cell, Cambridge University Press."},{"key":"ref_12","unstructured":"Rakic, P., and Singer, W. (1988). Principles of cortical network organization. Neurobiology of Neocortex, Wiley."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Luu, P., and Tucker, D.M. (2023). Continuity and change in neural plasticity through embryonic morphogenesis, fetal activity-dependent synaptogenesis, and infant memory consolidation. Dev. Psychobiol., 65.","DOI":"10.1002\/dev.22439"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.3758\/s13415-019-00721-3","article-title":"The hierarchically mechanistic mind: An evolutionary systems theory of the human brain, cognition, and behavior","volume":"19","author":"Badcock","year":"2019","journal-title":"Cogn. Affect. Behav. Neurosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/cercor\/bhad458","article-title":"From active affordance to active inference: Vertical integration of cognition in the cerebral cortex through dual subcortical control systems","volume":"34","author":"Luu","year":"2024","journal-title":"Cereb. Cortex"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s00429-019-01841-9","article-title":"The Structural Model: A theory linking connections, plasticity, pathology, development and evolution of the cerebral cortex","volume":"224","author":"Zikopoulos","year":"2019","journal-title":"Brain Struct. Funct."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/cercor\/bhaa228","article-title":"Bidirectional interaction of hippocampal ripples and cortical slow waves leads to coordinated spiking activity during NREM sleep","volume":"31","author":"Sanda","year":"2021","journal-title":"Cereb. Cortex"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.neuron.2012.10.038","article-title":"Canonical microcircuits for predictive coding","volume":"76","author":"Bastos","year":"2012","journal-title":"Neuron"},{"key":"ref_19","unstructured":"Bennett, M. (2023). A Brief History of Intelligence: Evolution, AI, and the Five Breakthroughs That Made Our Brains, Mariner Books."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Tucker, D.M. (2007). Mind from Body: Experience from Neural Structure, Oxford University Press.","DOI":"10.1093\/acprof:oso\/9780195316988.001.0001"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.neubiorev.2021.05.029","article-title":"Motive control of unconscious inference: The limbic base of adaptive Bayes","volume":"128","author":"Tucker","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7870","DOI":"10.1093\/cercor\/bhad085","article-title":"Adaptive control of functional connectivity: Dorsal and ventral limbic divisions regulate the dorsal and ventral neocortical networks","volume":"33","author":"Tucker","year":"2023","journal-title":"Cereb. Cortex"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Ororbia, A.G., and Friston, K. (2023). Mortal Computation: A Foundation for Biomimetic Intelligence. arXiv.","DOI":"10.31219\/osf.io\/epqkg"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1126\/science.1127647","article-title":"Reducing the dimensionality of data with neural networks","volume":"313","author":"Hinton","year":"2006","journal-title":"Science"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/1467-9450.00228","article-title":"Generative models, brain function and neuroimaging","volume":"42","author":"Friston","year":"2001","journal-title":"Scand. J. Psychol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nrn2787","article-title":"The free-energy principle: A unified brain theory?","volume":"11","author":"Friston","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.pneurobio.2012.05.003","article-title":"Waking and dreaming consciousness: Neurobiological and functional considerations","volume":"98","author":"Hobson","year":"2012","journal-title":"Prog. Neurobiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s00429-012-0475-5","article-title":"Predictions not commands: Active inference in the motor system","volume":"218","author":"Adams","year":"2013","journal-title":"Brain Struct. Funct."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nphys3230","article-title":"Thermodynamics of information","volume":"11","author":"Parrondo","year":"2015","journal-title":"Nat. Phys."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.plrev.2018.12.002","article-title":"Variational ecology and the physics of sentient systems","volume":"31","author":"Ramstead","year":"2019","journal-title":"Phys. Life Rev."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Friston, K.J., Wiese, W., and Hobson, J.A. (2020). Sentience and the origins of consciousness: From Cartesian duality to Markovian monism. Entropy, 22.","DOI":"10.3390\/e22050516"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Marsh, B.M., Navas-Zuloaga, M.G., Rosen, B.Q., Sokolov, Y., Delanois, J.E., Gonz\u00e1lez, O.C., Krishnan, G.P., Halgren, E., and Bazhenov, M. (2024). Emergent effects of synaptic connectivity on the dynamics of global and local slow waves in a large-scale thalamocortical network model of the human brain. bioRxiv.","DOI":"10.1101\/2023.10.15.562408"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1756-8765.2010.01127.x","article-title":"A neural model of rule generation in inductive reasoning","volume":"3","author":"Rasmussen","year":"2011","journal-title":"Top. Cogn. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Cohen-Duwek, H., Slovin, H., and Ezra Tsur, E. (2022). Computational modeling of color perception with biologically plausible spiking neural networks. PLoS Comput. Biol., 18.","DOI":"10.1371\/journal.pcbi.1010648"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Thakur, C.S., Molin, J.L., Cauwenberghs, G., Indiveri, G., Kumar, K., Qiao, N., Schemmel, J., Wang, R., Chicca, E., and Olson Hasler, J. (2018). Large-scale neuromorphic spiking array processors: A quest to mimic the brain. Front. Neurosci., 12.","DOI":"10.3389\/fnins.2018.00891"},{"key":"ref_36","first-page":"189","article-title":"Towards the virtual brain: Network modeling of the intact and the damaged brain","volume":"148","author":"Jirsa","year":"2010","journal-title":"Arch. Ital. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"042001","DOI":"10.1088\/2634-4386\/ad05da","article-title":"Spike-based local synaptic plasticity: A survey of computational models and neuromorphic circuits","volume":"3","author":"Khacef","year":"2023","journal-title":"Neuromorphic Comput. Eng."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"150501","DOI":"10.1063\/5.0020014","article-title":"Quantum neuromorphic computing","volume":"117","author":"Grollier","year":"2020","journal-title":"Appl. Phys. Lett."},{"key":"ref_39","unstructured":"Hinton, G. (2022). The forward-forward algorithm: Some preliminary investigations. arXiv."},{"key":"ref_40","unstructured":"Hinton, G., Vinyals, O., and Dean, J. (2015). Distilling the knowledge in a neural network. arXiv."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/cercor\/6.2.81","article-title":"The hippocampal-neocortical dialogue","volume":"6","author":"Buzsaki","year":"1996","journal-title":"Cereb. Cortex"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1038\/s41593-019-0467-3","article-title":"Mechanisms of systems memory consolidation during sleep","volume":"22","author":"Klinzing","year":"2019","journal-title":"Nat. Neurosci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"S77","DOI":"10.1093\/sleep\/17.suppl_8.S77","article-title":"Paradoxical sleep mechanisms","volume":"17","author":"Jouvet","year":"1994","journal-title":"Sleep"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Hobson, J.A. (2005). Dreaming: A Very Short Introduction, OUP Oxford.","DOI":"10.1093\/actrade\/9780192802156.001.0001"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nrn2762","article-title":"The memory function of sleep","volume":"11","author":"Diekelmann","year":"2010","journal-title":"Nat. Rev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1152\/physrev.00032.2012","article-title":"About sleep\u2019s role in memory","volume":"93","author":"Rasch","year":"2013","journal-title":"Physiol. Rev."},{"key":"ref_47","unstructured":"Mahler, M.S. (1968). On Human Symbiosis and the Vicissitudes of Individuation, International Universities Press."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nrn2716","article-title":"REM sleep and dreaming: Towards a theory of protoconsciousness","volume":"10","author":"Hobson","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_49","unstructured":"Tucker, D.M., and Johnson, M. Deep Feelings: The Emotional Sources of Imagination and Experience, MIT Press. in preparation."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/evan.21464","article-title":"Sleep intensity and the evolution of human cognition","volume":"24","author":"Samson","year":"2015","journal-title":"Evol. Anthropol. Issues News Rev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.sleep.2021.03.001","article-title":"Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep","volume":"81","author":"Hathaway","year":"2021","journal-title":"Sleep Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.clinph.2020.10.030","article-title":"Source localization of epileptic spikes using Multiple Sparse Priors","volume":"132","author":"Feng","year":"2021","journal-title":"Clin. Neurophysiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.neuroimage.2007.09.048","article-title":"Multiple sparse priors for the M\/EEG inverse problem","volume":"39","author":"Friston","year":"2008","journal-title":"Neuroimage"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s42454-022-00041-x","article-title":"A unified view of a human digital twin","volume":"4","author":"Miller","year":"2022","journal-title":"Hum.-Intell. Syst. Integr."},{"key":"ref_55","unstructured":"Tucker, D.M., Luu, P., Shusterman, R., and Turovets, S. (2024, January 10\u201313). Electrocortical Neuromorphic Augmented Cognition Transmission (ENACT) for Human Digital Twin Communication. Proceedings of the NATO Specialist Meeting on Human Digital Twin in the Military: Findings and Perspectives, Orlando, FL, USA."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Wright, J., and Bourke, P. (2024). Markov Blankets and Mirror Symmetries. Free Energy Minimization and Mesocortical Anatomy. Entropy, 26.","DOI":"10.20944\/preprints202402.1661.v1"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Friston, K. (2008). Hierarchical models in the brain. PLoS Comput. Biol., 4.","DOI":"10.1371\/journal.pcbi.1000211"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Friston, K. (2018). Am I Self-Conscious? (Or Does Self-Organization Entail Self-Consciousness?). Front. Psychol., 9.","DOI":"10.3389\/fpsyg.2018.00579"},{"key":"ref_59","unstructured":"Ingle, D.J., Mansfield, R.J.W., and Goodale, M.A. (1982). Two cortical visual systems. The Analysis of Visual Behavior, MIT Press."},{"key":"ref_60","unstructured":"Kant, I. (1781). Critique of Pure Reason, Macmillan and Son. Reprint publication 1881."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev-neuro-071714-033936","article-title":"General cortical and special prefrontal connections: Principles from structure to function","volume":"38","author":"Barbas","year":"2015","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1152\/jn.00328.2022","article-title":"Neurophysiological mechanisms of implicit and explicit memory in the process of consciousness","volume":"128","author":"Tucker","year":"2022","journal-title":"J. Neurophysiol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Chalmers, D. (2007). The hard problem of consciousness. Blackwell Companion Conscious, John Wiley & Sons.","DOI":"10.1002\/9780470751466.ch18"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1196\/annals.1440.004","article-title":"The neural correlates of consciousness: An update","volume":"1124","author":"Tononi","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/s41583-019-0150-4","article-title":"A contextual binding theory of episodic memory: Systems consolidation reconsidered","volume":"20","author":"Yonelinas","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrn755","article-title":"Control of goal-directed and stimulus-driven attention in the brain","volume":"3","author":"Corbetta","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_67","unstructured":"Tucker, D.M. (2024). Turning Left and Right: The Fragile Sanity of Nations, Amazon Kindle Publishing."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.tins.2013.06.004","article-title":"A developmental ontology for the mammalian brain based on the prosomeric model","volume":"36","author":"Puelles","year":"2013","journal-title":"Trends Neurosci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1017\/S1472928808000356","article-title":"Evolution of the thalamus: A morphological and functional review","volume":"4","author":"Butler","year":"2008","journal-title":"Thalamus Relat. Syst."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/00207727008920220","article-title":"Every good regulator of a system must be a model of that system","volume":"1","author":"Conant","year":"1970","journal-title":"Int. J. Syst. Sci."},{"key":"ref_71","unstructured":"Eliasmith, C., and Anderson, C.H. (2003). Neural Engineering: Computation, Representation, and Dynamics in Neurobiological Systems, MIT Press."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Tsur, E.E. (2021). Neuromorphic Engineering: The Scientist\u2019s, Algorithms Designer\u2019s and Computer Architect\u2019s Perspectives on Brain-Inspired Computing, CRC Press.","DOI":"10.1201\/9781003143499"}],"container-title":["Entropy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1099-4300\/26\/9\/759\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:48:50Z","timestamp":1760111330000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1099-4300\/26\/9\/759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,5]]},"references-count":72,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["e26090759"],"URL":"https:\/\/doi.org\/10.3390\/e26090759","relation":{},"ISSN":["1099-4300"],"issn-type":[{"type":"electronic","value":"1099-4300"}],"subject":[],"published":{"date-parts":[[2024,9,5]]}}}