{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:49:59Z","timestamp":1778568599121,"version":"3.51.4"},"reference-count":29,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development (ZonMw)","doi-asserted-by":"publisher","award":["09120012010063"],"award-info":[{"award-number":["09120012010063"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development (ZonMw)","doi-asserted-by":"publisher","award":["755320"],"award-info":[{"award-number":["755320"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development (ZonMw)","doi-asserted-by":"publisher","award":["848146"],"award-info":[{"award-number":["848146"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development (ZonMw)","doi-asserted-by":"publisher","award":["356405"],"award-info":[{"award-number":["356405"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development (ZonMw)","doi-asserted-by":"publisher","award":["322098"],"award-info":[{"award-number":["322098"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development (ZonMw)","doi-asserted-by":"publisher","award":["286284"],"award-info":[{"award-number":["286284"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development (ZonMw)","doi-asserted-by":"publisher","award":["134309 (Eye)"],"award-info":[{"award-number":["134309 (Eye)"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development (ZonMw)","doi-asserted-by":"publisher","award":["126925"],"award-info":[{"award-number":["126925"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development (ZonMw)","doi-asserted-by":"publisher","award":["121584"],"award-info":[{"award-number":["121584"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development (ZonMw)","doi-asserted-by":"publisher","award":["124282"],"award-info":[{"award-number":["124282"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development (ZonMw)","doi-asserted-by":"publisher","award":["129378 (Salve)"],"award-info":[{"award-number":["129378 (Salve)"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development (ZonMw)","doi-asserted-by":"publisher","award":["117797 (Gendi)"],"award-info":[{"award-number":["117797 (Gendi)"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development (ZonMw)","doi-asserted-by":"publisher","award":["141071 (Skidi)"],"award-info":[{"award-number":["141071 (Skidi)"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development (ZonMw)","doi-asserted-by":"publisher","award":["349708"],"award-info":[{"award-number":["349708"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development (ZonMw)","doi-asserted-by":"publisher","award":["X51001"],"award-info":[{"award-number":["X51001"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development (ZonMw)","doi-asserted-by":"publisher","award":["742927"],"award-info":[{"award-number":["742927"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development (ZonMw)","doi-asserted-by":"publisher","award":["101080117"],"award-info":[{"award-number":["101080117"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EU Horizon 2020","award":["09120012010063"],"award-info":[{"award-number":["09120012010063"]}]},{"name":"EU Horizon 2020","award":["755320"],"award-info":[{"award-number":["755320"]}]},{"name":"EU Horizon 2020","award":["848146"],"award-info":[{"award-number":["848146"]}]},{"name":"EU Horizon 2020","award":["356405"],"award-info":[{"award-number":["356405"]}]},{"name":"EU Horizon 2020","award":["322098"],"award-info":[{"award-number":["322098"]}]},{"name":"EU Horizon 2020","award":["286284"],"award-info":[{"award-number":["286284"]}]},{"name":"EU Horizon 2020","award":["134309 (Eye)"],"award-info":[{"award-number":["134309 (Eye)"]}]},{"name":"EU Horizon 2020","award":["126925"],"award-info":[{"award-number":["126925"]}]},{"name":"EU Horizon 2020","award":["121584"],"award-info":[{"award-number":["121584"]}]},{"name":"EU Horizon 2020","award":["124282"],"award-info":[{"award-number":["124282"]}]},{"name":"EU Horizon 2020","award":["129378 (Salve)"],"award-info":[{"award-number":["129378 (Salve)"]}]},{"name":"EU Horizon 2020","award":["117797 (Gendi)"],"award-info":[{"award-number":["117797 (Gendi)"]}]},{"name":"EU Horizon 2020","award":["141071 (Skidi)"],"award-info":[{"award-number":["141071 (Skidi)"]}]},{"name":"EU Horizon 2020","award":["349708"],"award-info":[{"award-number":["349708"]}]},{"name":"EU Horizon 2020","award":["X51001"],"award-info":[{"award-number":["X51001"]}]},{"name":"EU Horizon 2020","award":["742927"],"award-info":[{"award-number":["742927"]}]},{"name":"EU Horizon 2020","award":["101080117"],"award-info":[{"award-number":["101080117"]}]},{"name":"Academy of Finland","award":["09120012010063"],"award-info":[{"award-number":["09120012010063"]}]},{"name":"Academy of Finland","award":["755320"],"award-info":[{"award-number":["755320"]}]},{"name":"Academy of Finland","award":["848146"],"award-info":[{"award-number":["848146"]}]},{"name":"Academy of Finland","award":["356405"],"award-info":[{"award-number":["356405"]}]},{"name":"Academy of Finland","award":["322098"],"award-info":[{"award-number":["322098"]}]},{"name":"Academy of Finland","award":["286284"],"award-info":[{"award-number":["286284"]}]},{"name":"Academy of Finland","award":["134309 (Eye)"],"award-info":[{"award-number":["134309 (Eye)"]}]},{"name":"Academy of Finland","award":["126925"],"award-info":[{"award-number":["126925"]}]},{"name":"Academy of Finland","award":["121584"],"award-info":[{"award-number":["121584"]}]},{"name":"Academy of Finland","award":["124282"],"award-info":[{"award-number":["124282"]}]},{"name":"Academy of Finland","award":["129378 (Salve)"],"award-info":[{"award-number":["129378 (Salve)"]}]},{"name":"Academy of Finland","award":["117797 (Gendi)"],"award-info":[{"award-number":["117797 (Gendi)"]}]},{"name":"Academy of Finland","award":["141071 (Skidi)"],"award-info":[{"award-number":["141071 (Skidi)"]}]},{"name":"Academy of Finland","award":["349708"],"award-info":[{"award-number":["349708"]}]},{"name":"Academy of Finland","award":["X51001"],"award-info":[{"award-number":["X51001"]}]},{"name":"Academy of Finland","award":["742927"],"award-info":[{"award-number":["742927"]}]},{"name":"Academy of Finland","award":["101080117"],"award-info":[{"award-number":["101080117"]}]},{"name":"Social Insurance Institution of Finland","award":["09120012010063"],"award-info":[{"award-number":["09120012010063"]}]},{"name":"Social Insurance Institution of Finland","award":["755320"],"award-info":[{"award-number":["755320"]}]},{"name":"Social Insurance Institution of Finland","award":["848146"],"award-info":[{"award-number":["848146"]}]},{"name":"Social Insurance Institution of Finland","award":["356405"],"award-info":[{"award-number":["356405"]}]},{"name":"Social Insurance Institution of Finland","award":["322098"],"award-info":[{"award-number":["322098"]}]},{"name":"Social Insurance Institution of Finland","award":["286284"],"award-info":[{"award-number":["286284"]}]},{"name":"Social Insurance Institution of Finland","award":["134309 (Eye)"],"award-info":[{"award-number":["134309 (Eye)"]}]},{"name":"Social Insurance Institution of Finland","award":["126925"],"award-info":[{"award-number":["126925"]}]},{"name":"Social Insurance Institution of Finland","award":["121584"],"award-info":[{"award-number":["121584"]}]},{"name":"Social Insurance Institution of Finland","award":["124282"],"award-info":[{"award-number":["124282"]}]},{"name":"Social Insurance Institution of Finland","award":["129378 (Salve)"],"award-info":[{"award-number":["129378 (Salve)"]}]},{"name":"Social Insurance Institution of Finland","award":["117797 (Gendi)"],"award-info":[{"award-number":["117797 (Gendi)"]}]},{"name":"Social Insurance Institution of Finland","award":["141071 (Skidi)"],"award-info":[{"award-number":["141071 (Skidi)"]}]},{"name":"Social Insurance Institution of Finland","award":["349708"],"award-info":[{"award-number":["349708"]}]},{"name":"Social Insurance Institution of Finland","award":["X51001"],"award-info":[{"award-number":["X51001"]}]},{"name":"Social Insurance Institution of Finland","award":["742927"],"award-info":[{"award-number":["742927"]}]},{"name":"Social Insurance Institution of Finland","award":["101080117"],"award-info":[{"award-number":["101080117"]}]},{"name":"Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals","award":["09120012010063"],"award-info":[{"award-number":["09120012010063"]}]},{"name":"Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals","award":["755320"],"award-info":[{"award-number":["755320"]}]},{"name":"Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals","award":["848146"],"award-info":[{"award-number":["848146"]}]},{"name":"Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals","award":["356405"],"award-info":[{"award-number":["356405"]}]},{"name":"Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals","award":["322098"],"award-info":[{"award-number":["322098"]}]},{"name":"Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals","award":["286284"],"award-info":[{"award-number":["286284"]}]},{"name":"Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals","award":["134309 (Eye)"],"award-info":[{"award-number":["134309 (Eye)"]}]},{"name":"Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals","award":["126925"],"award-info":[{"award-number":["126925"]}]},{"name":"Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals","award":["121584"],"award-info":[{"award-number":["121584"]}]},{"name":"Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals","award":["124282"],"award-info":[{"award-number":["124282"]}]},{"name":"Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals","award":["129378 (Salve)"],"award-info":[{"award-number":["129378 (Salve)"]}]},{"name":"Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals","award":["117797 (Gendi)"],"award-info":[{"award-number":["117797 (Gendi)"]}]},{"name":"Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals","award":["141071 (Skidi)"],"award-info":[{"award-number":["141071 (Skidi)"]}]},{"name":"Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals","award":["349708"],"award-info":[{"award-number":["349708"]}]},{"name":"Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals","award":["X51001"],"award-info":[{"award-number":["X51001"]}]},{"name":"Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals","award":["742927"],"award-info":[{"award-number":["742927"]}]},{"name":"Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals","award":["101080117"],"award-info":[{"award-number":["101080117"]}]},{"name":"Juho Vainio Foundation","award":["09120012010063"],"award-info":[{"award-number":["09120012010063"]}]},{"name":"Juho Vainio Foundation","award":["755320"],"award-info":[{"award-number":["755320"]}]},{"name":"Juho Vainio Foundation","award":["848146"],"award-info":[{"award-number":["848146"]}]},{"name":"Juho Vainio Foundation","award":["356405"],"award-info":[{"award-number":["356405"]}]},{"name":"Juho Vainio Foundation","award":["322098"],"award-info":[{"award-number":["322098"]}]},{"name":"Juho Vainio Foundation","award":["286284"],"award-info":[{"award-number":["286284"]}]},{"name":"Juho Vainio Foundation","award":["134309 (Eye)"],"award-info":[{"award-number":["134309 (Eye)"]}]},{"name":"Juho Vainio Foundation","award":["126925"],"award-info":[{"award-number":["126925"]}]},{"name":"Juho Vainio Foundation","award":["121584"],"award-info":[{"award-number":["121584"]}]},{"name":"Juho Vainio Foundation","award":["124282"],"award-info":[{"award-number":["124282"]}]},{"name":"Juho Vainio Foundation","award":["129378 (Salve)"],"award-info":[{"award-number":["129378 (Salve)"]}]},{"name":"Juho Vainio Foundation","award":["117797 (Gendi)"],"award-info":[{"award-number":["117797 (Gendi)"]}]},{"name":"Juho Vainio Foundation","award":["141071 (Skidi)"],"award-info":[{"award-number":["141071 (Skidi)"]}]},{"name":"Juho Vainio Foundation","award":["349708"],"award-info":[{"award-number":["349708"]}]},{"name":"Juho Vainio Foundation","award":["X51001"],"award-info":[{"award-number":["X51001"]}]},{"name":"Juho Vainio Foundation","award":["742927"],"award-info":[{"award-number":["742927"]}]},{"name":"Juho Vainio Foundation","award":["101080117"],"award-info":[{"award-number":["101080117"]}]},{"name":"Paavo Nurmi Foundation","award":["09120012010063"],"award-info":[{"award-number":["09120012010063"]}]},{"name":"Paavo Nurmi Foundation","award":["755320"],"award-info":[{"award-number":["755320"]}]},{"name":"Paavo Nurmi Foundation","award":["848146"],"award-info":[{"award-number":["848146"]}]},{"name":"Paavo Nurmi Foundation","award":["356405"],"award-info":[{"award-number":["356405"]}]},{"name":"Paavo Nurmi Foundation","award":["322098"],"award-info":[{"award-number":["322098"]}]},{"name":"Paavo Nurmi Foundation","award":["286284"],"award-info":[{"award-number":["286284"]}]},{"name":"Paavo Nurmi Foundation","award":["134309 (Eye)"],"award-info":[{"award-number":["134309 (Eye)"]}]},{"name":"Paavo Nurmi Foundation","award":["126925"],"award-info":[{"award-number":["126925"]}]},{"name":"Paavo Nurmi Foundation","award":["121584"],"award-info":[{"award-number":["121584"]}]},{"name":"Paavo Nurmi Foundation","award":["124282"],"award-info":[{"award-number":["124282"]}]},{"name":"Paavo Nurmi Foundation","award":["129378 (Salve)"],"award-info":[{"award-number":["129378 (Salve)"]}]},{"name":"Paavo Nurmi Foundation","award":["117797 (Gendi)"],"award-info":[{"award-number":["117797 (Gendi)"]}]},{"name":"Paavo Nurmi Foundation","award":["141071 (Skidi)"],"award-info":[{"award-number":["141071 (Skidi)"]}]},{"name":"Paavo Nurmi Foundation","award":["349708"],"award-info":[{"award-number":["349708"]}]},{"name":"Paavo Nurmi Foundation","award":["X51001"],"award-info":[{"award-number":["X51001"]}]},{"name":"Paavo Nurmi Foundation","award":["742927"],"award-info":[{"award-number":["742927"]}]},{"name":"Paavo Nurmi Foundation","award":["101080117"],"award-info":[{"award-number":["101080117"]}]},{"name":"Finnish Foundation for Cardiovascular Research","award":["09120012010063"],"award-info":[{"award-number":["09120012010063"]}]},{"name":"Finnish Foundation for Cardiovascular Research","award":["755320"],"award-info":[{"award-number":["755320"]}]},{"name":"Finnish Foundation for Cardiovascular Research","award":["848146"],"award-info":[{"award-number":["848146"]}]},{"name":"Finnish Foundation for Cardiovascular Research","award":["356405"],"award-info":[{"award-number":["356405"]}]},{"name":"Finnish Foundation for Cardiovascular Research","award":["322098"],"award-info":[{"award-number":["322098"]}]},{"name":"Finnish Foundation for Cardiovascular Research","award":["286284"],"award-info":[{"award-number":["286284"]}]},{"name":"Finnish Foundation for Cardiovascular Research","award":["134309 (Eye)"],"award-info":[{"award-number":["134309 (Eye)"]}]},{"name":"Finnish Foundation for Cardiovascular Research","award":["126925"],"award-info":[{"award-number":["126925"]}]},{"name":"Finnish Foundation for Cardiovascular Research","award":["121584"],"award-info":[{"award-number":["121584"]}]},{"name":"Finnish Foundation for Cardiovascular Research","award":["124282"],"award-info":[{"award-number":["124282"]}]},{"name":"Finnish Foundation for Cardiovascular Research","award":["129378 (Salve)"],"award-info":[{"award-number":["129378 (Salve)"]}]},{"name":"Finnish Foundation for Cardiovascular Research","award":["117797 (Gendi)"],"award-info":[{"award-number":["117797 (Gendi)"]}]},{"name":"Finnish Foundation for Cardiovascular Research","award":["141071 (Skidi)"],"award-info":[{"award-number":["141071 (Skidi)"]}]},{"name":"Finnish Foundation for Cardiovascular Research","award":["349708"],"award-info":[{"award-number":["349708"]}]},{"name":"Finnish Foundation for Cardiovascular Research","award":["X51001"],"award-info":[{"award-number":["X51001"]}]},{"name":"Finnish Foundation for Cardiovascular Research","award":["742927"],"award-info":[{"award-number":["742927"]}]},{"name":"Finnish Foundation for Cardiovascular Research","award":["101080117"],"award-info":[{"award-number":["101080117"]}]},{"name":"Finnish Cultural Foundation","award":["09120012010063"],"award-info":[{"award-number":["09120012010063"]}]},{"name":"Finnish Cultural Foundation","award":["755320"],"award-info":[{"award-number":["755320"]}]},{"name":"Finnish Cultural Foundation","award":["848146"],"award-info":[{"award-number":["848146"]}]},{"name":"Finnish Cultural Foundation","award":["356405"],"award-info":[{"award-number":["356405"]}]},{"name":"Finnish Cultural Foundation","award":["322098"],"award-info":[{"award-number":["322098"]}]},{"name":"Finnish Cultural Foundation","award":["286284"],"award-info":[{"award-number":["286284"]}]},{"name":"Finnish Cultural Foundation","award":["134309 (Eye)"],"award-info":[{"award-number":["134309 (Eye)"]}]},{"name":"Finnish Cultural Foundation","award":["126925"],"award-info":[{"award-number":["126925"]}]},{"name":"Finnish Cultural Foundation","award":["121584"],"award-info":[{"award-number":["121584"]}]},{"name":"Finnish Cultural Foundation","award":["124282"],"award-info":[{"award-number":["124282"]}]},{"name":"Finnish Cultural Foundation","award":["129378 (Salve)"],"award-info":[{"award-number":["129378 (Salve)"]}]},{"name":"Finnish Cultural Foundation","award":["117797 (Gendi)"],"award-info":[{"award-number":["117797 (Gendi)"]}]},{"name":"Finnish Cultural Foundation","award":["141071 (Skidi)"],"award-info":[{"award-number":["141071 (Skidi)"]}]},{"name":"Finnish Cultural Foundation","award":["349708"],"award-info":[{"award-number":["349708"]}]},{"name":"Finnish Cultural Foundation","award":["X51001"],"award-info":[{"award-number":["X51001"]}]},{"name":"Finnish Cultural Foundation","award":["742927"],"award-info":[{"award-number":["742927"]}]},{"name":"Finnish Cultural Foundation","award":["101080117"],"award-info":[{"award-number":["101080117"]}]},{"name":"Sigrid Juselius Foundation","award":["09120012010063"],"award-info":[{"award-number":["09120012010063"]}]},{"name":"Sigrid Juselius Foundation","award":["755320"],"award-info":[{"award-number":["755320"]}]},{"name":"Sigrid Juselius Foundation","award":["848146"],"award-info":[{"award-number":["848146"]}]},{"name":"Sigrid Juselius Foundation","award":["356405"],"award-info":[{"award-number":["356405"]}]},{"name":"Sigrid Juselius Foundation","award":["322098"],"award-info":[{"award-number":["322098"]}]},{"name":"Sigrid Juselius Foundation","award":["286284"],"award-info":[{"award-number":["286284"]}]},{"name":"Sigrid Juselius Foundation","award":["134309 (Eye)"],"award-info":[{"award-number":["134309 (Eye)"]}]},{"name":"Sigrid Juselius Foundation","award":["126925"],"award-info":[{"award-number":["126925"]}]},{"name":"Sigrid Juselius Foundation","award":["121584"],"award-info":[{"award-number":["121584"]}]},{"name":"Sigrid Juselius Foundation","award":["124282"],"award-info":[{"award-number":["124282"]}]},{"name":"Sigrid Juselius Foundation","award":["129378 (Salve)"],"award-info":[{"award-number":["129378 (Salve)"]}]},{"name":"Sigrid Juselius Foundation","award":["117797 (Gendi)"],"award-info":[{"award-number":["117797 (Gendi)"]}]},{"name":"Sigrid Juselius Foundation","award":["141071 (Skidi)"],"award-info":[{"award-number":["141071 (Skidi)"]}]},{"name":"Sigrid Juselius Foundation","award":["349708"],"award-info":[{"award-number":["349708"]}]},{"name":"Sigrid Juselius Foundation","award":["X51001"],"award-info":[{"award-number":["X51001"]}]},{"name":"Sigrid Juselius Foundation","award":["742927"],"award-info":[{"award-number":["742927"]}]},{"name":"Sigrid Juselius Foundation","award":["101080117"],"award-info":[{"award-number":["101080117"]}]},{"name":"Tampere Tuberculosis Foundation","award":["09120012010063"],"award-info":[{"award-number":["09120012010063"]}]},{"name":"Tampere Tuberculosis Foundation","award":["755320"],"award-info":[{"award-number":["755320"]}]},{"name":"Tampere Tuberculosis Foundation","award":["848146"],"award-info":[{"award-number":["848146"]}]},{"name":"Tampere Tuberculosis Foundation","award":["356405"],"award-info":[{"award-number":["356405"]}]},{"name":"Tampere Tuberculosis Foundation","award":["322098"],"award-info":[{"award-number":["322098"]}]},{"name":"Tampere Tuberculosis Foundation","award":["286284"],"award-info":[{"award-number":["286284"]}]},{"name":"Tampere Tuberculosis Foundation","award":["134309 (Eye)"],"award-info":[{"award-number":["134309 (Eye)"]}]},{"name":"Tampere Tuberculosis Foundation","award":["126925"],"award-info":[{"award-number":["126925"]}]},{"name":"Tampere Tuberculosis Foundation","award":["121584"],"award-info":[{"award-number":["121584"]}]},{"name":"Tampere Tuberculosis Foundation","award":["124282"],"award-info":[{"award-number":["124282"]}]},{"name":"Tampere Tuberculosis Foundation","award":["129378 (Salve)"],"award-info":[{"award-number":["129378 (Salve)"]}]},{"name":"Tampere Tuberculosis Foundation","award":["117797 (Gendi)"],"award-info":[{"award-number":["117797 (Gendi)"]}]},{"name":"Tampere Tuberculosis Foundation","award":["141071 (Skidi)"],"award-info":[{"award-number":["141071 (Skidi)"]}]},{"name":"Tampere Tuberculosis Foundation","award":["349708"],"award-info":[{"award-number":["349708"]}]},{"name":"Tampere Tuberculosis Foundation","award":["X51001"],"award-info":[{"award-number":["X51001"]}]},{"name":"Tampere Tuberculosis Foundation","award":["742927"],"award-info":[{"award-number":["742927"]}]},{"name":"Tampere Tuberculosis Foundation","award":["101080117"],"award-info":[{"award-number":["101080117"]}]},{"name":"Emil Aaltonen Foundation","award":["09120012010063"],"award-info":[{"award-number":["09120012010063"]}]},{"name":"Emil Aaltonen Foundation","award":["755320"],"award-info":[{"award-number":["755320"]}]},{"name":"Emil Aaltonen Foundation","award":["848146"],"award-info":[{"award-number":["848146"]}]},{"name":"Emil Aaltonen Foundation","award":["356405"],"award-info":[{"award-number":["356405"]}]},{"name":"Emil Aaltonen Foundation","award":["322098"],"award-info":[{"award-number":["322098"]}]},{"name":"Emil Aaltonen Foundation","award":["286284"],"award-info":[{"award-number":["286284"]}]},{"name":"Emil Aaltonen Foundation","award":["134309 (Eye)"],"award-info":[{"award-number":["134309 (Eye)"]}]},{"name":"Emil Aaltonen Foundation","award":["126925"],"award-info":[{"award-number":["126925"]}]},{"name":"Emil Aaltonen Foundation","award":["121584"],"award-info":[{"award-number":["121584"]}]},{"name":"Emil Aaltonen Foundation","award":["124282"],"award-info":[{"award-number":["124282"]}]},{"name":"Emil Aaltonen Foundation","award":["129378 (Salve)"],"award-info":[{"award-number":["129378 (Salve)"]}]},{"name":"Emil Aaltonen Foundation","award":["117797 (Gendi)"],"award-info":[{"award-number":["117797 (Gendi)"]}]},{"name":"Emil Aaltonen Foundation","award":["141071 (Skidi)"],"award-info":[{"award-number":["141071 (Skidi)"]}]},{"name":"Emil Aaltonen Foundation","award":["349708"],"award-info":[{"award-number":["349708"]}]},{"name":"Emil Aaltonen Foundation","award":["X51001"],"award-info":[{"award-number":["X51001"]}]},{"name":"Emil Aaltonen Foundation","award":["742927"],"award-info":[{"award-number":["742927"]}]},{"name":"Emil Aaltonen Foundation","award":["101080117"],"award-info":[{"award-number":["101080117"]}]},{"name":"Yrj\u00c3\u0171 Jahnsson Foundation","award":["09120012010063"],"award-info":[{"award-number":["09120012010063"]}]},{"name":"Yrj\u00c3\u0171 Jahnsson Foundation","award":["755320"],"award-info":[{"award-number":["755320"]}]},{"name":"Yrj\u00c3\u0171 Jahnsson Foundation","award":["848146"],"award-info":[{"award-number":["848146"]}]},{"name":"Yrj\u00c3\u0171 Jahnsson Foundation","award":["356405"],"award-info":[{"award-number":["356405"]}]},{"name":"Yrj\u00c3\u0171 Jahnsson Foundation","award":["322098"],"award-info":[{"award-number":["322098"]}]},{"name":"Yrj\u00c3\u0171 Jahnsson Foundation","award":["286284"],"award-info":[{"award-number":["286284"]}]},{"name":"Yrj\u00c3\u0171 Jahnsson Foundation","award":["134309 (Eye)"],"award-info":[{"award-number":["134309 (Eye)"]}]},{"name":"Yrj\u00c3\u0171 Jahnsson Foundation","award":["126925"],"award-info":[{"award-number":["126925"]}]},{"name":"Yrj\u00c3\u0171 Jahnsson Foundation","award":["121584"],"award-info":[{"award-number":["121584"]}]},{"name":"Yrj\u00c3\u0171 Jahnsson Foundation","award":["124282"],"award-info":[{"award-number":["124282"]}]},{"name":"Yrj\u00c3\u0171 Jahnsson Foundation","award":["129378 (Salve)"],"award-info":[{"award-number":["129378 (Salve)"]}]},{"name":"Yrj\u00c3\u0171 Jahnsson Foundation","award":["117797 (Gendi)"],"award-info":[{"award-number":["117797 (Gendi)"]}]},{"name":"Yrj\u00c3\u0171 Jahnsson Foundation","award":["141071 (Skidi)"],"award-info":[{"award-number":["141071 (Skidi)"]}]},{"name":"Yrj\u00c3\u0171 Jahnsson Foundation","award":["349708"],"award-info":[{"award-number":["349708"]}]},{"name":"Yrj\u00c3\u0171 Jahnsson Foundation","award":["X51001"],"award-info":[{"award-number":["X51001"]}]},{"name":"Yrj\u00c3\u0171 Jahnsson Foundation","award":["742927"],"award-info":[{"award-number":["742927"]}]},{"name":"Yrj\u00c3\u0171 Jahnsson Foundation","award":["101080117"],"award-info":[{"award-number":["101080117"]}]},{"name":"Signe and Ane Gyllenberg Foundation","award":["09120012010063"],"award-info":[{"award-number":["09120012010063"]}]},{"name":"Signe and Ane Gyllenberg Foundation","award":["755320"],"award-info":[{"award-number":["755320"]}]},{"name":"Signe and Ane Gyllenberg Foundation","award":["848146"],"award-info":[{"award-number":["848146"]}]},{"name":"Signe and Ane Gyllenberg Foundation","award":["356405"],"award-info":[{"award-number":["356405"]}]},{"name":"Signe and Ane Gyllenberg Foundation","award":["322098"],"award-info":[{"award-number":["322098"]}]},{"name":"Signe and Ane Gyllenberg Foundation","award":["286284"],"award-info":[{"award-number":["286284"]}]},{"name":"Signe and Ane Gyllenberg Foundation","award":["134309 (Eye)"],"award-info":[{"award-number":["134309 (Eye)"]}]},{"name":"Signe and Ane Gyllenberg Foundation","award":["126925"],"award-info":[{"award-number":["126925"]}]},{"name":"Signe and Ane Gyllenberg Foundation","award":["121584"],"award-info":[{"award-number":["121584"]}]},{"name":"Signe and Ane Gyllenberg Foundation","award":["124282"],"award-info":[{"award-number":["124282"]}]},{"name":"Signe and Ane Gyllenberg Foundation","award":["129378 (Salve)"],"award-info":[{"award-number":["129378 (Salve)"]}]},{"name":"Signe and Ane Gyllenberg Foundation","award":["117797 (Gendi)"],"award-info":[{"award-number":["117797 (Gendi)"]}]},{"name":"Signe and Ane Gyllenberg Foundation","award":["141071 (Skidi)"],"award-info":[{"award-number":["141071 (Skidi)"]}]},{"name":"Signe and Ane Gyllenberg Foundation","award":["349708"],"award-info":[{"award-number":["349708"]}]},{"name":"Signe and Ane Gyllenberg Foundation","award":["X51001"],"award-info":[{"award-number":["X51001"]}]},{"name":"Signe and Ane Gyllenberg Foundation","award":["742927"],"award-info":[{"award-number":["742927"]}]},{"name":"Signe and Ane Gyllenberg Foundation","award":["101080117"],"award-info":[{"award-number":["101080117"]}]},{"name":"Diabetes Research Foundation of Finnish Diabetes Association","award":["09120012010063"],"award-info":[{"award-number":["09120012010063"]}]},{"name":"Diabetes Research Foundation of Finnish Diabetes Association","award":["755320"],"award-info":[{"award-number":["755320"]}]},{"name":"Diabetes Research Foundation of Finnish Diabetes Association","award":["848146"],"award-info":[{"award-number":["848146"]}]},{"name":"Diabetes Research Foundation of Finnish Diabetes Association","award":["356405"],"award-info":[{"award-number":["356405"]}]},{"name":"Diabetes Research Foundation of Finnish Diabetes Association","award":["322098"],"award-info":[{"award-number":["322098"]}]},{"name":"Diabetes Research Foundation of Finnish Diabetes Association","award":["286284"],"award-info":[{"award-number":["286284"]}]},{"name":"Diabetes Research Foundation of Finnish Diabetes Association","award":["134309 (Eye)"],"award-info":[{"award-number":["134309 (Eye)"]}]},{"name":"Diabetes Research Foundation of Finnish Diabetes Association","award":["126925"],"award-info":[{"award-number":["126925"]}]},{"name":"Diabetes Research Foundation of Finnish Diabetes Association","award":["121584"],"award-info":[{"award-number":["121584"]}]},{"name":"Diabetes Research Foundation of Finnish Diabetes Association","award":["124282"],"award-info":[{"award-number":["124282"]}]},{"name":"Diabetes Research Foundation of Finnish Diabetes Association","award":["129378 (Salve)"],"award-info":[{"award-number":["129378 (Salve)"]}]},{"name":"Diabetes Research Foundation of Finnish Diabetes Association","award":["117797 (Gendi)"],"award-info":[{"award-number":["117797 (Gendi)"]}]},{"name":"Diabetes Research Foundation of Finnish Diabetes Association","award":["141071 (Skidi)"],"award-info":[{"award-number":["141071 (Skidi)"]}]},{"name":"Diabetes Research Foundation of Finnish Diabetes Association","award":["349708"],"award-info":[{"award-number":["349708"]}]},{"name":"Diabetes Research Foundation of Finnish Diabetes Association","award":["X51001"],"award-info":[{"award-number":["X51001"]}]},{"name":"Diabetes Research Foundation of Finnish Diabetes Association","award":["742927"],"award-info":[{"award-number":["742927"]}]},{"name":"Diabetes Research Foundation of Finnish Diabetes Association","award":["101080117"],"award-info":[{"award-number":["101080117"]}]},{"name":"European Research Council","award":["09120012010063"],"award-info":[{"award-number":["09120012010063"]}]},{"name":"European Research Council","award":["755320"],"award-info":[{"award-number":["755320"]}]},{"name":"European Research Council","award":["848146"],"award-info":[{"award-number":["848146"]}]},{"name":"European Research Council","award":["356405"],"award-info":[{"award-number":["356405"]}]},{"name":"European Research Council","award":["322098"],"award-info":[{"award-number":["322098"]}]},{"name":"European Research Council","award":["286284"],"award-info":[{"award-number":["286284"]}]},{"name":"European Research Council","award":["134309 (Eye)"],"award-info":[{"award-number":["134309 (Eye)"]}]},{"name":"European Research Council","award":["126925"],"award-info":[{"award-number":["126925"]}]},{"name":"European Research Council","award":["121584"],"award-info":[{"award-number":["121584"]}]},{"name":"European Research Council","award":["124282"],"award-info":[{"award-number":["124282"]}]},{"name":"European Research Council","award":["129378 (Salve)"],"award-info":[{"award-number":["129378 (Salve)"]}]},{"name":"European Research Council","award":["117797 (Gendi)"],"award-info":[{"award-number":["117797 (Gendi)"]}]},{"name":"European Research Council","award":["141071 (Skidi)"],"award-info":[{"award-number":["141071 (Skidi)"]}]},{"name":"European Research Council","award":["349708"],"award-info":[{"award-number":["349708"]}]},{"name":"European Research Council","award":["X51001"],"award-info":[{"award-number":["X51001"]}]},{"name":"European Research Council","award":["742927"],"award-info":[{"award-number":["742927"]}]},{"name":"European Research Council","award":["101080117"],"award-info":[{"award-number":["101080117"]}]},{"name":"Tampere University Hospital Supporting Foundation","award":["09120012010063"],"award-info":[{"award-number":["09120012010063"]}]},{"name":"Tampere University Hospital Supporting Foundation","award":["755320"],"award-info":[{"award-number":["755320"]}]},{"name":"Tampere University Hospital Supporting Foundation","award":["848146"],"award-info":[{"award-number":["848146"]}]},{"name":"Tampere University Hospital Supporting Foundation","award":["356405"],"award-info":[{"award-number":["356405"]}]},{"name":"Tampere University Hospital Supporting Foundation","award":["322098"],"award-info":[{"award-number":["322098"]}]},{"name":"Tampere University Hospital Supporting Foundation","award":["286284"],"award-info":[{"award-number":["286284"]}]},{"name":"Tampere University Hospital Supporting Foundation","award":["134309 (Eye)"],"award-info":[{"award-number":["134309 (Eye)"]}]},{"name":"Tampere University Hospital Supporting Foundation","award":["126925"],"award-info":[{"award-number":["126925"]}]},{"name":"Tampere University Hospital Supporting Foundation","award":["121584"],"award-info":[{"award-number":["121584"]}]},{"name":"Tampere University Hospital Supporting Foundation","award":["124282"],"award-info":[{"award-number":["124282"]}]},{"name":"Tampere University Hospital Supporting Foundation","award":["129378 (Salve)"],"award-info":[{"award-number":["129378 (Salve)"]}]},{"name":"Tampere University Hospital Supporting Foundation","award":["117797 (Gendi)"],"award-info":[{"award-number":["117797 (Gendi)"]}]},{"name":"Tampere University Hospital Supporting Foundation","award":["141071 (Skidi)"],"award-info":[{"award-number":["141071 (Skidi)"]}]},{"name":"Tampere University Hospital Supporting Foundation","award":["349708"],"award-info":[{"award-number":["349708"]}]},{"name":"Tampere University Hospital Supporting Foundation","award":["X51001"],"award-info":[{"award-number":["X51001"]}]},{"name":"Tampere University Hospital Supporting Foundation","award":["742927"],"award-info":[{"award-number":["742927"]}]},{"name":"Tampere University Hospital Supporting Foundation","award":["101080117"],"award-info":[{"award-number":["101080117"]}]},{"name":"Finnish Society of Clinical Chemistry","award":["09120012010063"],"award-info":[{"award-number":["09120012010063"]}]},{"name":"Finnish Society of Clinical Chemistry","award":["755320"],"award-info":[{"award-number":["755320"]}]},{"name":"Finnish Society of Clinical Chemistry","award":["848146"],"award-info":[{"award-number":["848146"]}]},{"name":"Finnish Society of Clinical Chemistry","award":["356405"],"award-info":[{"award-number":["356405"]}]},{"name":"Finnish Society of Clinical Chemistry","award":["322098"],"award-info":[{"award-number":["322098"]}]},{"name":"Finnish Society of Clinical Chemistry","award":["286284"],"award-info":[{"award-number":["286284"]}]},{"name":"Finnish Society of Clinical Chemistry","award":["134309 (Eye)"],"award-info":[{"award-number":["134309 (Eye)"]}]},{"name":"Finnish Society of Clinical Chemistry","award":["126925"],"award-info":[{"award-number":["126925"]}]},{"name":"Finnish Society of Clinical Chemistry","award":["121584"],"award-info":[{"award-number":["121584"]}]},{"name":"Finnish Society of Clinical Chemistry","award":["124282"],"award-info":[{"award-number":["124282"]}]},{"name":"Finnish Society of Clinical Chemistry","award":["129378 (Salve)"],"award-info":[{"award-number":["129378 (Salve)"]}]},{"name":"Finnish Society of Clinical Chemistry","award":["117797 (Gendi)"],"award-info":[{"award-number":["117797 (Gendi)"]}]},{"name":"Finnish Society of Clinical Chemistry","award":["141071 (Skidi)"],"award-info":[{"award-number":["141071 (Skidi)"]}]},{"name":"Finnish Society of Clinical Chemistry","award":["349708"],"award-info":[{"award-number":["349708"]}]},{"name":"Finnish Society of Clinical Chemistry","award":["X51001"],"award-info":[{"award-number":["X51001"]}]},{"name":"Finnish Society of Clinical Chemistry","award":["742927"],"award-info":[{"award-number":["742927"]}]},{"name":"Finnish Society of Clinical Chemistry","award":["101080117"],"award-info":[{"award-number":["101080117"]}]},{"name":"Cancer Foundation Finland","award":["09120012010063"],"award-info":[{"award-number":["09120012010063"]}]},{"name":"Cancer Foundation Finland","award":["755320"],"award-info":[{"award-number":["755320"]}]},{"name":"Cancer Foundation Finland","award":["848146"],"award-info":[{"award-number":["848146"]}]},{"name":"Cancer Foundation Finland","award":["356405"],"award-info":[{"award-number":["356405"]}]},{"name":"Cancer Foundation Finland","award":["322098"],"award-info":[{"award-number":["322098"]}]},{"name":"Cancer Foundation Finland","award":["286284"],"award-info":[{"award-number":["286284"]}]},{"name":"Cancer Foundation Finland","award":["134309 (Eye)"],"award-info":[{"award-number":["134309 (Eye)"]}]},{"name":"Cancer Foundation Finland","award":["126925"],"award-info":[{"award-number":["126925"]}]},{"name":"Cancer Foundation Finland","award":["121584"],"award-info":[{"award-number":["121584"]}]},{"name":"Cancer Foundation Finland","award":["124282"],"award-info":[{"award-number":["124282"]}]},{"name":"Cancer Foundation Finland","award":["129378 (Salve)"],"award-info":[{"award-number":["129378 (Salve)"]}]},{"name":"Cancer Foundation Finland","award":["117797 (Gendi)"],"award-info":[{"award-number":["117797 (Gendi)"]}]},{"name":"Cancer Foundation Finland","award":["141071 (Skidi)"],"award-info":[{"award-number":["141071 (Skidi)"]}]},{"name":"Cancer Foundation Finland","award":["349708"],"award-info":[{"award-number":["349708"]}]},{"name":"Cancer Foundation Finland","award":["X51001"],"award-info":[{"award-number":["X51001"]}]},{"name":"Cancer Foundation Finland","award":["742927"],"award-info":[{"award-number":["742927"]}]},{"name":"Cancer Foundation Finland","award":["101080117"],"award-info":[{"award-number":["101080117"]}]},{"name":"pBETTER4U_EU","award":["09120012010063"],"award-info":[{"award-number":["09120012010063"]}]},{"name":"pBETTER4U_EU","award":["755320"],"award-info":[{"award-number":["755320"]}]},{"name":"pBETTER4U_EU","award":["848146"],"award-info":[{"award-number":["848146"]}]},{"name":"pBETTER4U_EU","award":["356405"],"award-info":[{"award-number":["356405"]}]},{"name":"pBETTER4U_EU","award":["322098"],"award-info":[{"award-number":["322098"]}]},{"name":"pBETTER4U_EU","award":["286284"],"award-info":[{"award-number":["286284"]}]},{"name":"pBETTER4U_EU","award":["134309 (Eye)"],"award-info":[{"award-number":["134309 (Eye)"]}]},{"name":"pBETTER4U_EU","award":["126925"],"award-info":[{"award-number":["126925"]}]},{"name":"pBETTER4U_EU","award":["121584"],"award-info":[{"award-number":["121584"]}]},{"name":"pBETTER4U_EU","award":["124282"],"award-info":[{"award-number":["124282"]}]},{"name":"pBETTER4U_EU","award":["129378 (Salve)"],"award-info":[{"award-number":["129378 (Salve)"]}]},{"name":"pBETTER4U_EU","award":["117797 (Gendi)"],"award-info":[{"award-number":["117797 (Gendi)"]}]},{"name":"pBETTER4U_EU","award":["141071 (Skidi)"],"award-info":[{"award-number":["141071 (Skidi)"]}]},{"name":"pBETTER4U_EU","award":["349708"],"award-info":[{"award-number":["349708"]}]},{"name":"pBETTER4U_EU","award":["X51001"],"award-info":[{"award-number":["X51001"]}]},{"name":"pBETTER4U_EU","award":["742927"],"award-info":[{"award-number":["742927"]}]},{"name":"pBETTER4U_EU","award":["101080117"],"award-info":[{"award-number":["101080117"]}]},{"name":"Jane and Aatos Erkko Foundation","award":["09120012010063"],"award-info":[{"award-number":["09120012010063"]}]},{"name":"Jane and Aatos Erkko Foundation","award":["755320"],"award-info":[{"award-number":["755320"]}]},{"name":"Jane and Aatos Erkko Foundation","award":["848146"],"award-info":[{"award-number":["848146"]}]},{"name":"Jane and Aatos Erkko Foundation","award":["356405"],"award-info":[{"award-number":["356405"]}]},{"name":"Jane and Aatos Erkko Foundation","award":["322098"],"award-info":[{"award-number":["322098"]}]},{"name":"Jane and Aatos Erkko Foundation","award":["286284"],"award-info":[{"award-number":["286284"]}]},{"name":"Jane and Aatos Erkko Foundation","award":["134309 (Eye)"],"award-info":[{"award-number":["134309 (Eye)"]}]},{"name":"Jane and Aatos Erkko Foundation","award":["126925"],"award-info":[{"award-number":["126925"]}]},{"name":"Jane and Aatos Erkko Foundation","award":["121584"],"award-info":[{"award-number":["121584"]}]},{"name":"Jane and Aatos Erkko Foundation","award":["124282"],"award-info":[{"award-number":["124282"]}]},{"name":"Jane and Aatos Erkko Foundation","award":["129378 (Salve)"],"award-info":[{"award-number":["129378 (Salve)"]}]},{"name":"Jane and Aatos Erkko Foundation","award":["117797 (Gendi)"],"award-info":[{"award-number":["117797 (Gendi)"]}]},{"name":"Jane and Aatos Erkko Foundation","award":["141071 (Skidi)"],"award-info":[{"award-number":["141071 (Skidi)"]}]},{"name":"Jane and Aatos Erkko Foundation","award":["349708"],"award-info":[{"award-number":["349708"]}]},{"name":"Jane and Aatos Erkko Foundation","award":["X51001"],"award-info":[{"award-number":["X51001"]}]},{"name":"Jane and Aatos Erkko Foundation","award":["742927"],"award-info":[{"award-number":["742927"]}]},{"name":"Jane and Aatos Erkko Foundation","award":["101080117"],"award-info":[{"award-number":["101080117"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Entropy"],"abstract":"<jats:p>In recent years, there has been a notably increased interest in the study of multivariate interactions and emergent higher-order dependencies. This is particularly evident in the context of identifying synergistic sets, which are defined as combinations of elements whose joint interactions result in the emergence of information that is not present in any individual subset of those elements. The scalability of frameworks such as partial information decomposition (PID) and those based on multivariate extensions of mutual information, such as O-information, is limited by combinational explosion in the number of sets that must be assessed. In order to address these challenges, we propose a novel approach that utilises stochastic search strategies in order to identify synergistic triplets within datasets. Furthermore, the methodology is extensible to larger sets and various synergy measures. By employing stochastic search, our approach circumvents the constraints of exhaustive enumeration, offering a scalable and efficient means to uncover intricate dependencies. The flexibility of our method is illustrated through its application to two epidemiological datasets: The Young Finns Study and the UK Biobank Nuclear Magnetic Resonance (NMR) data. Additionally, we present a heuristic for reducing the number of synergistic sets to analyse in large datasets by excluding sets with overlapping information. We also illustrate the risks of performing a feature selection before assessing synergistic information in the system.<\/jats:p>","DOI":"10.3390\/e26110968","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T08:12:39Z","timestamp":1731399159000},"page":"968","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficient Search Algorithms for Identifying Synergistic Associations in High-Dimensional Datasets"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3161-0736","authenticated-orcid":false,"given":"Cillian","family":"Hourican","sequence":"first","affiliation":[{"name":"Computational Science Lab, Institute of Informatics, University of Amsterdam, 1012 WP Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Computational Science Lab, Institute of Informatics, University of Amsterdam, 1012 WP Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5177-3431","authenticated-orcid":false,"given":"Pashupati P.","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, 33100 Tampere, Finland"},{"name":"Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, 33100 Tampere, Finland"},{"name":"Department of Clinical Chemistry, Fimlab Laboratories, 33520 Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terho","family":"Lehtim\u00e4ki","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, 33100 Tampere, Finland"},{"name":"Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, 33100 Tampere, Finland"},{"name":"Department of Clinical Chemistry, Fimlab Laboratories, 33520 Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binisha H.","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, 33100 Tampere, Finland"},{"name":"Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, 33100 Tampere, Finland"},{"name":"Department of Clinical Chemistry, Fimlab Laboratories, 33520 Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"K\u00e4h\u00f6nen","sequence":"additional","affiliation":[{"name":"Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, 33100 Tampere, Finland"},{"name":"Department of Clinical Physiology, Tampere University Hospital, 33520 Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olli T.","family":"Raitakari","sequence":"additional","affiliation":[{"name":"Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20014 Turku, Finland"},{"name":"Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, 33520 Turku, Finland"},{"name":"Centre for Population Health Research, University of Turku and Turku University Hospital, 20520 Turku, Finland"},{"name":"InFLAMES Research Flagship, University of Turku, 20014 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reijo","family":"Laaksonen","sequence":"additional","affiliation":[{"name":"Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, 33100 Tampere, Finland"},{"name":"Zora Biosciences Oy, 02150 Espoo, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7977-3852","authenticated-orcid":false,"given":"Liisa","family":"Keltikangas-J\u00e4rvinen","sequence":"additional","affiliation":[{"name":"Department of Psychology and Logopedics, University of Helsinki, 00100 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9498-364X","authenticated-orcid":false,"given":"Markus","family":"Juonala","sequence":"additional","affiliation":[{"name":"Division of Medicine, Turku University Hospital, 20520 Turku, Finland"},{"name":"Department of Medicine, University of Turku, 20014 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0299-0074","authenticated-orcid":false,"given":"Rick","family":"Quax","sequence":"additional","affiliation":[{"name":"Computational Science Lab, Institute of Informatics, University of Amsterdam, 1012 WP Amsterdam, The Netherlands"},{"name":"Institute for Advanced Study, 1012 GC Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Stramaglia, S., Scagliarini, T., Daniels, B.C., and Marinazzo, D. (2021). Quantifying Dynamical High-Order Interdependencies From the O-Information: An Application to Neural Spiking Dynamics. Front. Physiol., 11.","DOI":"10.3389\/fphys.2020.595736"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Santos, F.A.N., Tewarie, P.K.B., Baudot, P., Luchicchi, A., Barros De Souza, D., Girier, G., Milan, A.P., Broeders, T., Centeno, E.G.Z., and Cofre, R. (2023). Emergence of High-Order Functional Hubs in the Human Brain. bioRxiv.","DOI":"10.1101\/2023.02.10.528083"},{"key":"ref_3","unstructured":"Clauw, K., Stramaglia, S., and Marinazzo, D. (2022). Higher-order mutual information reveals synergistic sub-networks for multi-neuron importance. arXiv."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Faes, L., Mijatovic, G., Sparacino, L., Pernice, R., Antonacci, Y., Porta, A., and Stramaglia, S. (2022, January 9\u201312). Quantifying High-Order Interactions in Cardiovascular and Cerebrovascular Networks. Proceedings of the 2022 12th Conference of the European Study Group on Cardiovascular Oscillations, ESGCO 2022, Vysok\u00c3l\u2019 Tatry, \u00c5\u0103trbsk\u00c3l\u2019 Pleso, Slovakia.","DOI":"10.1109\/ESGCO55423.2022.9931385"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Hourican, C., Peeters, G., Melis, R.J., Wezeman, S.L., Gill, T.M., Olde Rikkert, M.G., and Quax, R. (2023). Understanding multimorbidity requires sign-disease networks and higher-order interactions, a perspective. Front. Syst. Biol., 3.","DOI":"10.3389\/fsysb.2023.1155599"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1089\/brain.2020.0982","article-title":"High-Order Interdependencies in the Aging Brain","volume":"11","author":"Gatica","year":"2021","journal-title":"Brain Connect."},{"key":"ref_7","unstructured":"Marinazzo, D., Roozendaal, J.V., Rosas, F.E., Stella, M., Comolatti, R., Colenbier, N., Stramaglia, S., and Rosseel, Y. (2022). INFO-HYPERGRAPHS IN PSYCHOMETRICS 1 An information-theoretic approach to hypergraph psychometrics. arXiv."},{"key":"ref_8","unstructured":"Williams, P.L., and Beer, R.D. (2010). Nonnegative Decomposition of Multivariate Information. arXiv."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Lizier, J.T., Bertschinger, N., Jost, J., and Wibral, M. (2018). Information decomposition of target effects from multi-source interactions: Perspectives on previous, current and futurework. Entropy, 20.","DOI":"10.3390\/e20040307"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Quax, R., Har-Shemesh, O., and Sloot, P.M. (2017). Quantifying Synergistic Information Using Intermediate Stochastic Variables. Entropy, 19.","DOI":"10.3390\/e19020085"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Perrone, P., and Ay, N. (2015). Hierarchical Quantification of Synergy in Channels. arXiv.","DOI":"10.3389\/frobt.2015.00035"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"032305","DOI":"10.1103\/PhysRevE.100.032305","article-title":"Quantifying High-order Interdependencies via Multivariate Extensions of the Mutual Information","volume":"100","author":"Rosas","year":"2019","journal-title":"Phys. Rev. E"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1093\/ije\/dym225","article-title":"Cohort Profile: The Cardiovascular Risk in Young Finns Study","volume":"37","author":"Raitakari","year":"2008","journal-title":"Int. J. Epidemiol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Sudlow, C., Gallacher, J., Allen, N., Beral, V., Burton, P., Danesh, J., Downey, P., Elliott, P., Green, J., and Landray, M. (2015). UK biobank: An open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med., 12.","DOI":"10.1371\/journal.pmed.1001779"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Makkeh, A., Theis, D., and Vicente, R. (2017). Bivariate Partial Information Decomposition: The Optimization Perspective. Entropy, 19.","DOI":"10.3390\/e19100530"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.21105\/joss.01081","article-title":"IDTxl: The Information Dynamics Toolkit xl: A Python package for the efficient analysis of multivariate information dynamics in networks","volume":"4","author":"Wollstadt","year":"2019","journal-title":"J. Open Source Softw."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Antonacci, Y., Astolfi, L., Nollo, G., and Faes, L. (2020). Information Transfer in Linear Multivariate Processes Assessed through Penalized Regression Techniques: Validation and Application to Physiological Networks. Entropy, 22.","DOI":"10.3390\/e22070732"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"013184","DOI":"10.1103\/PhysRevResearch.4.013184","article-title":"Quantifying high-order interdependencies on individual patterns via the local O-information: Theory and applications to music analysis","volume":"4","author":"Scagliarini","year":"2022","journal-title":"Phys. Rev. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5766","DOI":"10.1109\/TSP.2022.3221892","article-title":"A New Framework for the Time-and Frequency-Domain Assessment of High-Order Interactions in Networks of Random Processes","volume":"70","author":"Faes","year":"2022","journal-title":"IEEE Trans. Signal Process."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"013025","DOI":"10.1103\/PhysRevResearch.5.013025","article-title":"Gradients of O-information: Low-order descriptors of high-order dependencies","volume":"5","author":"Scagliarini","year":"2022","journal-title":"Phys. Rev. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/s41567-022-01548-5","article-title":"Disentangling high-order mechanisms and high-order behaviours in complex systems","volume":"18","author":"Rosas","year":"2022","journal-title":"Nat. Phys."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Varley, T.F., Pope, M., Faskowitz, J., and Sporns, O. (2023). Multivariate information theory uncovers synergistic subsystems of the human cerebral cortex. Commun. Biol., 6.","DOI":"10.1038\/s42003-023-04843-w"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3390\/make1010010","article-title":"Particle Swarm Optimization: A survey of historical and recent developments with hybridization perspectives","volume":"1","author":"Sengupta","year":"2018","journal-title":"Mach. Learn. Knowl. Extr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11704-018-7155-4","article-title":"Set-based discrete particle swarm optimization and its applications: A survey","volume":"12","author":"Chen","year":"2018","journal-title":"Front. Comput. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1109\/TCYB.2017.2728120","article-title":"Set-Based Discrete Particle Swarm Optimization Based on Decomposition for Permutation-Based Multiobjective Combinatorial Optimization Problems","volume":"48","author":"Yu","year":"2018","journal-title":"IEEE Trans. Cybern."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3233\/IDA-173735","article-title":"Feature selection using a set based discrete particle swarm optimization and a novel feature subset evaluation criterion","volume":"23","author":"Qiu","year":"2019","journal-title":"Intell. Data Anal."},{"key":"ref_27","first-page":"2825","article-title":"Scikit-learn: Machine learning in Python","volume":"12","author":"Pedregosa","year":"2011","journal-title":"J. Mach. Learn. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"100099","DOI":"10.1016\/j.jlr.2021.100099","article-title":"Apolipoprotein A-I modulates HDL particle size in the absence of apolipoprotein A-II","volume":"62","author":"Melchior","year":"2021","journal-title":"J. Lipid Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0022-2275(20)38540-0","article-title":"Interactions of high density lipoproteins with very low and low density lipoproteins during lipolysis","volume":"29","author":"Musliner","year":"1988","journal-title":"J. Lipid Res."}],"container-title":["Entropy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1099-4300\/26\/11\/968\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:30:24Z","timestamp":1760113824000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1099-4300\/26\/11\/968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,11]]},"references-count":29,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["e26110968"],"URL":"https:\/\/doi.org\/10.3390\/e26110968","relation":{},"ISSN":["1099-4300"],"issn-type":[{"value":"1099-4300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,11]]}}}