{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:21:10Z","timestamp":1762604470013,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T00:00:00Z","timestamp":1734048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Youth Fund of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62103301","2022ZD038","2022KJ114","2021KJ013","KYQD202358","KYQD1810"],"award-info":[{"award-number":["62103301","2022ZD038","2022KJ114","2021KJ013","KYQD202358","KYQD1810"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Research Project of Tianjin Education Commission, China","award":["62103301","2022ZD038","2022KJ114","2021KJ013","KYQD202358","KYQD1810"],"award-info":[{"award-number":["62103301","2022ZD038","2022KJ114","2021KJ013","KYQD202358","KYQD1810"]}]},{"name":"Research Initiation Project of Tianjin University of Technology and Education","award":["62103301","2022ZD038","2022KJ114","2021KJ013","KYQD202358","KYQD1810"],"award-info":[{"award-number":["62103301","2022ZD038","2022KJ114","2021KJ013","KYQD202358","KYQD1810"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Entropy"],"abstract":"<jats:p>Acupuncturing the ST36 acupoint can evoke a responding activity in the spinal dorsal root ganglia and generate spikes. In order to identify the responding mechanism of different acupuncture manipulations, in this paper the spike history of neurons is taken as the starting point and the coupling generalized linear model is adopted to encode the neuronal spiking activity evoked by different acupuncture manipulations. Then, maximum likelihood estimation is used to fit the model parameters and estimate the coupling parameters of stimulus, the self-coupling parameters of the neuron\u2019s own spike history and the cross-coupling parameters of other neurons\u2019 spike history. We use simulation data to test the estimation algorithm\u2019s effectiveness and analyze the main factors that evoke neuronal responding activity. Finally, we use the coupling generalized linear model to encode neuronal spiking activity evoked by two acupuncture manipulations, and estimate the coupling parameters of stimulus, the self-coupling parameters and the cross-coupling parameters. The results show that in acupuncture experiments, acupuncture stimulus is the inducing factor of neuronal spiking activity, and the cross-coupling of other neurons\u2019 spike history is the main factor of neuronal spiking activity. Additionally, the higher the amplitude of the neuronal spiking waveform, the greater the cross-coupling parameter. This lays a theoretical foundation for the scientific application of acupuncture therapy.<\/jats:p>","DOI":"10.3390\/e26121088","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T03:51:08Z","timestamp":1734061868000},"page":"1088","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Charactering Neural Spiking Activity Evoked by Acupuncture Through Coupling Generalized Linear Model"],"prefix":"10.3390","volume":"26","author":[{"given":"Qing","family":"Qin","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Information Sensing & Intelligent Control, Tianjin University of Technology and Education, Tianjin 300222, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Information Sensing & Intelligent Control, Tianjin University of Technology and Education, Tianjin 300222, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5988-7908","authenticated-orcid":false,"given":"Yanqiu","family":"Che","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Information Sensing & Intelligent Control, Tianjin University of Technology and Education, Tianjin 300222, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0647-1834","authenticated-orcid":false,"given":"Chunxiao","family":"Han","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Information Sensing & Intelligent Control, Tianjin University of Technology and Education, Tianjin 300222, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9912-4780","authenticated-orcid":false,"given":"Yingmei","family":"Qin","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Information Sensing & Intelligent Control, Tianjin University of Technology and Education, Tianjin 300222, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Information Sensing & Intelligent Control, Tianjin University of Technology and Education, Tianjin 300222, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s11726-017-0999-6","article-title":"Overview of researches on central action mechanism of needling Zusanli (ST 36)","volume":"15","author":"Liu","year":"2017","journal-title":"J. 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