{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:18:41Z","timestamp":1760235521224,"version":"build-2065373602"},"reference-count":70,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Future Internet"],"abstract":"<jats:p>As part of studies that employ health electronic records databases, this paper advocates the employment of graph theory for investigating drug-switching behaviors. Unlike the shared approach in this field (comparing groups that have switched with control groups), network theory can provide information about actual switching behavior patterns. After a brief and simple introduction to fundamental concepts of network theory, here we present (i) a Python script to obtain an adjacency matrix from a records database and (ii) an illustrative example of the application of network theory basic concepts to investigate drug-switching behaviors. Further potentialities of network theory (weighted matrices and the use of clustering algorithms), along with the generalization of these methods to other kinds of switching behaviors beyond drug switching, are discussed.<\/jats:p>","DOI":"10.3390\/fi13090228","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T21:59:45Z","timestamp":1630447185000},"page":"228","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Network Theory and Switching Behaviors: A User Guide for Analyzing Electronic Records Databases"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0543-4900","authenticated-orcid":false,"given":"Giorgio","family":"Gronchi","sequence":"first","affiliation":[{"name":"Section of Psychology, Department of Neuroscience, Psychology, Drug Research and Child\u2019s Health (NEUROFARBA), University of Florence, 12 Via di San Salvi, 50135 Firenze, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6878-5604","authenticated-orcid":false,"given":"Marco","family":"Raglianti","sequence":"additional","affiliation":[{"name":"Software Institute, Universit\u00e0 della Svizzera Italiana (USI), 1 Via la Santa, 6962 Lugano, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1059-9945","authenticated-orcid":false,"given":"Fabio","family":"Giovannelli","sequence":"additional","affiliation":[{"name":"Section of Psychology, Department of Neuroscience, Psychology, Drug Research and Child\u2019s Health (NEUROFARBA), University of Florence, 12 Via di San Salvi, 50135 Firenze, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.pmcj.2015.04.003","article-title":"Monitoring elderly behavior via indoor position-based stigmergy","volume":"23","author":"Barsocchi","year":"2015","journal-title":"Pervasive Mob. Comput."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1080\/13651501.2017.1315139","article-title":"A unique database for gathering data from a mobile app and medical prescription software: A useful data source to collect and analyse patient-reported outcomes of depression and anxiety symptoms","volume":"21","author":"Watanabe","year":"2017","journal-title":"Int. J. Psychiatry Clin. Pract."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ijhcs.2014.08.003","article-title":"Cognitive dissonance and social influence effects on preference judgments: An eye tracking based system for their automatic assessment","volume":"73","author":"Guazzini","year":"2015","journal-title":"Int. J. Hum. Comput. Stud."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1007\/s00268-017-4019-2","article-title":"Natural history of MEN1 GEP-NET: Single-center experience after a long follow-up","volume":"41","author":"Giudici","year":"2017","journal-title":"World J. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s00223-018-0405-5","article-title":"Affiliations expand Prevalence of chronic hypoparathyroidism in a Mediterranean region as estimated by the analysis of anonymous healthcare database","volume":"103","author":"Cianferotti","year":"2018","journal-title":"Calcif. Tissue Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s11657-017-0333-4","article-title":"Calcium intake, bone mineral density, and fragility fractures: Evidence from an Italian outpatient population","volume":"12","author":"Vannucci","year":"2017","journal-title":"Arch. Osteoporos."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1056\/NEJMsa0900592","article-title":"Use of electronic health records in US hospitals","volume":"360","author":"Jha","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s10072-015-2062-z","article-title":"Reliability of administrative data for the identification of Parkinson\u2019s disease cohorts","volume":"36","author":"Baldacci","year":"2015","journal-title":"Neurol. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Shao, Y., Durmus, N., Zhang, Y., Pehlivan, S., Fernandez-Beros, M.-E., Umana, L., Corona, R., Addessi, A., Abbott, S.A., and Smyth-Giambanco, S. (2021). The Development of a WTC Environmental Health Center Pan-Cancer Database. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18041646"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Concheiro-Moscoso, P., Mart\u00ednez-Mart\u00ednez, F.J., Miranda-Duro, M.d.C., Pousada, T., Nieto-Riveiro, L., Groba, B., Mejuto-Mui\u00f1o, F.J., and Pereira, J. (2021). Study Protocol on the Validation of the Quality of Sleep Data from Xiaomi Domestic Wristbands. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18031106"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Wu, M.-H., Li, C.-Y., Pan, H., and Lin, Y.-C. (2019). The Relationship between Scabies and Stroke: A Population-Based Nationwide Study. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16183491"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.3389\/fpsyg.2018.01095","article-title":"The Use of Network Theory for Analyzing Switching Behaviors: Assessing Cognitive and Educational-Based Intervention for Promoting Health","volume":"9","author":"Gronchi","year":"2018","journal-title":"Front. Psychol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1742-7843.2006.pto_368.x","article-title":"Use of health care databases in pharmacoepidemiology","volume":"98","author":"Hennessy","year":"2006","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.therap.2018.12.004","article-title":"How the new European data protection regulation affects clinical research and recommendations?","volume":"74","author":"Cornu","year":"2019","journal-title":"Therapies"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"363","DOI":"10.11613\/BM.2020.030201","article-title":"Before and after enforcement of GDPR: Personal data protection requests received by Croatian Personal Data Protection Agency from academic and research institutions","volume":"30","author":"Puljak","year":"2020","journal-title":"Biochem. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s10586-020-03106-1","article-title":"Privacy preservation in e-health cloud: Taxonomy, privacy requirements, feasibility analysis, and opportunities","volume":"24","author":"Kanwal","year":"2021","journal-title":"Clust. Comput."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"148550","DOI":"10.1109\/ACCESS.2019.2946983","article-title":"SoK of used cryptography in blockchain","volume":"7","author":"Raikwar","year":"2019","journal-title":"IEEE Access"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e28496","DOI":"10.2196\/28496","article-title":"Blockchain for Increased Trust in Virtual Health Care: Proof-of-Concept Study","volume":"23","author":"Hasselgren","year":"2021","journal-title":"J. Med. Internet Res."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Hasselgren, A., Wan, P.K., Horn, M., Kralevska, K., Gligoroski, D., and Faxvaag, A. (2020, January 24\u201325). GDPR Compliance for Blockchain Applications in Healthcare. Proceedings of the International Conference on Big Data, IOT and Blockchain (BIBC 2020), Dubai, United Arab Emirates.","DOI":"10.5121\/csit.2020.101303"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1007\/s00198-015-3187-x","article-title":"Changing patterns of prescription in vitamin D supplementation in adults: Analysis of a regional dataset","volume":"26","author":"Cianferotti","year":"2015","journal-title":"Osteoporos. Int."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Ingrasciotta, Y., Bertuccio, M.P., Crisafulli, S., Ientile, V., Muscianisi, M., L\u2019Abbate, L., Pastorello, M., Provenzano, V., Scorsone, A., and Scondotto, S. (2020). Real World Use of Antidiabetic Drugs in the Years 2011\u20132017: A Population-Based Study from Southern Italy. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17249514"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Bounoure, F., Mouly, D., Beaudeau, P., Bentayeb, M., Chesneau, J., Jones, G., Skiba, M., Lahiani-Skiba, M., and Galey, C. (2020). Syndromic Surveillance of Acute Gastroenteritis Using the French Health Insurance Database: Discriminatory Algorithm and Drug Prescription Practices Evaluations. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17124301"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12913-020-05494-x","article-title":"Drug switching in The Netherlands: A cohort study of 20 active substances","volume":"20","author":"Glerum","year":"2020","journal-title":"BMC Health Serv. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1007\/s40262-020-00909-8","article-title":"Pharmacokinetics and Generic Drug Switching: A Regulator\u2019s View","volume":"59","author":"Glerum","year":"2020","journal-title":"Clin. Pharmacokinet."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/pds.653","article-title":"Drug switching patterns among patients taking non-steroidal anti-inflammatory drugs: A retrospective cohort study of a general practitioners database in the United Kingdom","volume":"10","author":"Langman","year":"2001","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Linton, D., Procyshyn, R.M., Elbe, D., Lee, L.H.N., and Barr, B.M. (2013). A retrospective study of antipsychotic drug switching in a pediatric population. BMC Psychiatry, 13.","DOI":"10.1186\/1471-244X-13-248"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"152","DOI":"10.18773\/austprescr.2019.052","article-title":"Stopping and switching antipsychotic drugs","volume":"42","author":"Keks","year":"2019","journal-title":"Aust. Prescr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/1359105305048552","article-title":"Theory-based behavior change interventions: Comments on Hobbis and Sutton","volume":"10","author":"Fishbein","year":"2005","journal-title":"J. Health Psychol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.amepre.2008.09.040","article-title":"Behavior change interventions delivered by mobile telephone short-message service","volume":"36","author":"Fjeldsoe","year":"2009","journal-title":"Am. J. Prev. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1037\/0278-6133.27.3.379","article-title":"A taxonomy of behavior change techniques used in interventions","volume":"27","author":"Abraham","year":"2008","journal-title":"Health Psychol."},{"key":"ref_31","first-page":"216","article-title":"How effective are behavior change interventions based on the theory of planned behavior? A three-level meta-analysis","volume":"224","author":"Steinmetz","year":"2016","journal-title":"Z. Psychol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e019221","DOI":"10.1136\/bmjopen-2017-019221","article-title":"What interventions are used to improve exercise adherence in older people and what behavioural techniques are they based on? A systematic review","volume":"7","author":"Room","year":"2017","journal-title":"BMJ Open"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1001\/jama.2018.19271","article-title":"Interventions to improve medication adherence: A review","volume":"320","author":"Kini","year":"2018","journal-title":"JAMA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1364\/JOSA.53.000179","article-title":"Studies of Anomalous Contrast and Assimilation","volume":"53","author":"Helson","year":"1963","journal-title":"J. Opt. Soc. Am."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0010-0285(83)90018-X","article-title":"Context, categorization, and recall: The \u201cchange-of-standard\u201d effect","volume":"15","author":"Higgins","year":"1983","journal-title":"Cogn. Psychol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actpsy.2015.05.001","article-title":"You are that smiling guy I met at the party! Socially positive signals foster memory for identities and contexts","volume":"159","author":"Righi","year":"2015","journal-title":"Acta Psychol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpsycho.2016.05.008","article-title":"Emotional contexts modulate intentional memory suppression of neutral faces: Insights from ERPs","volume":"106","author":"Pierguidi","year":"2016","journal-title":"Int. J. Psychophysiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1037\/0022-3514.38.1.131","article-title":"Contrast effects and judgments of physical attractiveness: When beauty becomes a social problem","volume":"38","author":"Kenrick","year":"1980","journal-title":"J. Pers. Soc. Psychol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4992\/psycholres1954.35.36","article-title":"The effect of decision frame and decision justification on risky choice","volume":"35","author":"Takemura","year":"1993","journal-title":"Jpn. Psychol. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1126\/science.1128356","article-title":"Frames, biases, and rational decision-making in the human brain","volume":"313","author":"Kumaran","year":"2006","journal-title":"Science"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.psychsport.2018.04.001","article-title":"Contextual factors influencing decision making: Perceptions of professional soccer players","volume":"37","author":"Levi","year":"2018","journal-title":"Psychol. Sport Exerc."},{"key":"ref_42","first-page":"1106","article-title":"Contextual factors in clinical decision making: National survey of Canadian family physicians","volume":"51","author":"Tracy","year":"2005","journal-title":"Can. Fam. Physician"},{"key":"ref_43","unstructured":"Thaler, R.H., and Sunstein, C.R. (2008). Nudge: Improving Decisions about Health, Wealth, and Happiness. Theory, Penguin Books."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.3389\/fpsyg.2018.01237","article-title":"Dual process theory of thought and default mode network: A possible neural foundation of fast thinking","volume":"9","author":"Gronchi","year":"2018","journal-title":"Front. Psychol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1037\/0033-2909.119.1.3","article-title":"The empirical case for two systems of reasoning","volume":"119","author":"Sloman","year":"1996","journal-title":"Psychol. Bull."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.tics.2003.08.012","article-title":"In two minds: Dual-process accounts of reasoning","volume":"7","author":"Evans","year":"2003","journal-title":"Trends Cogn. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"988","DOI":"10.3758\/BF03196730","article-title":"An evaluation of dual-process theories of reasoning","volume":"11","author":"Osman","year":"2004","journal-title":"Psychon. Bull. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/j.1528-1167.2007.01007.x","article-title":"Compulsory generic switching of antiepileptic drugs: High switchback rates to branded compounds compared with other drug classes","volume":"48","author":"Andermann","year":"2007","journal-title":"Epilepsia"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1001\/jama.2008.758","article-title":"Clinical equivalence of generic and brand-name drugs used in cardiovascular disease: A systematic review and meta-analysis","volume":"300","author":"Kesselheim","year":"2008","journal-title":"JAMA"},{"key":"ref_50","first-page":"47","article-title":"Switching antiretroviral drugs for treatment of metabolic complications in HIV-1 infection: Summary of selected trials","volume":"10","author":"Saag","year":"2002","journal-title":"Top. HIV Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1007\/s00198-008-0618-y","article-title":"Outcomes after switching from one bisphosphonatesphosphonate to another in 146 patients at a single university hospital","volume":"19","author":"Ideguchi","year":"2008","journal-title":"Osteopor. Int."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1345\/aph.1K671","article-title":"Contrasting measures of adherence with simple drug use, medication switching, and therapeutic duplication","volume":"43","author":"Martin","year":"2009","journal-title":"Ann. Pharmacother."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Kolaczyk, E.D., and Cs\u00e1rdi, G. (2014). Statistical Analysis of Network Data with R, Springer.","DOI":"10.1007\/978-1-4939-0983-4"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Luke, D.A. (2015). A User\u2019s Guide to Network Analysis in R, Springer.","DOI":"10.1007\/978-3-319-23883-8"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0167-8116(96)00022-5","article-title":"Network analyses of brand switching behavior","volume":"13","author":"Iacobucci","year":"1996","journal-title":"Int. J. Res. Mark."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Hansen, D.L., Shneiderman, B., Smith, M.A., and Himelboim, I. (2011). Social network analysis: Measuring, mapping, and modeling collections of connections. Analyzing Social Media Networks with NodeXL, Morgan Kaufmann.","DOI":"10.1016\/B978-0-12-382229-1.00003-5"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nature03607","article-title":"Uncovering the overlapping community structure of complex networks in nature and society","volume":"435","author":"Palla","year":"2005","journal-title":"Nature"},{"key":"ref_58","unstructured":"R Core Team (2020). R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing. Available online: https:\/\/www.R-project.org\/."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.21105\/joss.01686","article-title":"Welcome to the tidyverse","volume":"4","author":"Wickham","year":"2019","journal-title":"J. Open Source Soft."},{"key":"ref_60","first-page":"1","article-title":"The igraph software package for complex network research","volume":"1695","author":"Csardi","year":"2006","journal-title":"J. Complex Syst."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1093\/ajhp\/59.suppl_8.S22","article-title":"Rationale and strategies for switching antipsychotics","volume":"59","author":"Ganguli","year":"2002","journal-title":"Am. J. Health Syst. Pharm."},{"key":"ref_62","first-page":"670","article-title":"The effect of switching on compliance and persistence: The case of statin treatment","volume":"11","author":"Thiebaud","year":"2005","journal-title":"Am. J. Manag. Care"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1038\/s41598-020-60298-7","article-title":"A Comparative Analysis of Link Removal Strategies in Real Complex Weighted Networks","volume":"10","author":"Bellingeri","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"10692","DOI":"10.1038\/s41598-019-47119-2","article-title":"The Heterogeneity in Link Weights May Decrease the Robustness of Real-World Complex Weighted Networks","volume":"9","author":"Bellingeri","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Rodriguez, M.Z., Comin, C.H., Casanova, D., Bruno, O.M., Amancio, D.R., Costa, L.D.F., and Rodrigues, F.A. (2019). Clustering algorithms: A comparative approach. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0210236"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1093\/comnet\/cnu035","article-title":"Mapping cortical functions with a local community detection algorithm","volume":"2","author":"Gronchi","year":"2014","journal-title":"J. Complex Netw."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Vannucci, L., Fossi, C., Quattrini, S., Guasti, L., Pampaloni, B., Gronchi, G., Giusti, F., Romagnoli, C., Cianferotti, L., and Marcucci, G. (2018). Calcium intake in bone health: A focus on calcium-rich mineral waters. Nutrients, 10.","DOI":"10.3390\/nu10121930"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/puar.12564","article-title":"The theory and practice of \u201cnudging\u201d: Changing health behaviors","volume":"76","author":"Vlaev","year":"2016","journal-title":"Public Adm. Rev."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"502","DOI":"10.3389\/fphar.2019.00502","article-title":"Are Patients with Schizophrenia Spectrum Disorders More Prone to Manifest Nocebo-Like-Effects? A Meta-Analysis of Adverse Events in Placebo Groups of Double-Blind Antipsychotic Trials","volume":"10","author":"Palermo","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.yebeh.2014.12.004","article-title":"Placebo and nocebo responses in drug trials of epilepsy","volume":"43","author":"Zaccara","year":"2015","journal-title":"Epilepsy Behav."}],"container-title":["Future Internet"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-5903\/13\/9\/228\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:53:41Z","timestamp":1760165621000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-5903\/13\/9\/228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,31]]},"references-count":70,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["fi13090228"],"URL":"https:\/\/doi.org\/10.3390\/fi13090228","relation":{},"ISSN":["1999-5903"],"issn-type":[{"type":"electronic","value":"1999-5903"}],"subject":[],"published":{"date-parts":[[2021,8,31]]}}}