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This type of system acquires data from various sensors, runs analytics to understand people\u2019s activities, behavior, and living problems, and disseminates information with healthcare stakeholders to support timely follow-up and intervention. Blockchain technology may offer good technical solutions for tackling Internet of Things monitoring, data management, interventions, and privacy concerns in ambient assisted living applications. Even though the integration of blockchain technology with assisted care is still at the beginning, it has the potential to change the health and care processes through a secure transfer of patient data, better integration of care services, or by increasing coordination and awareness across the continuum of care. The motivation of this paper is to systematically review and organize these elements according to the main problems addressed. To the best of our knowledge, there are no studies conducted that address the solutions for integrating blockchain technology with ambient assisted living systems. To conduct the review, we have followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology with clear criteria for including and excluding papers, allowing the reader to effortlessly gain insights into the current state-of-the-art research in the field. The results highlight the advantages and open issues that would require increased attention from the research community in the coming years. As for directions for further research, we have identified data sharing and integration of care paths with blockchain, storage, and transactional costs, personalization of data disclosure paths, interoperability with legacy care systems, legal issues, and digital rights management.<\/jats:p>","DOI":"10.3390\/fi14050150","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T21:46:53Z","timestamp":1652392013000},"page":"150","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A Review of Blockchain Technology Applications in Ambient Assisted Living"],"prefix":"10.3390","volume":"14","author":[{"given":"Alexandru-Ioan","family":"Florea","sequence":"first","affiliation":[{"name":"Computer Science Department, Technical University of Cluj-Napoca, Memorandumului 28, 400114 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6166-5266","authenticated-orcid":false,"given":"Ionut","family":"Anghel","sequence":"additional","affiliation":[{"name":"Computer Science Department, Technical University of Cluj-Napoca, Memorandumului 28, 400114 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tudor","family":"Cioara","sequence":"additional","affiliation":[{"name":"Computer Science Department, Technical University of Cluj-Napoca, Memorandumului 28, 400114 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Cicirelli, G., Marani, R., Petitti, A., Milella, A., and D\u2019Orazio, T. 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