{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T21:54:37Z","timestamp":1763330077429,"version":"build-2065373602"},"reference-count":57,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Information"],"abstract":"<jats:p>Background: Some evidence of the value of 18F-fluorodesoxyglucose ([18F]FDG) positron emission tomography (PET) imaging for the assessment of gliomas and glioblastomas (GBMs) is emerging. The aim of this systematic review was to assess the role of [18F]FDG PET-based radiomics and machine learning (ML) in the evaluation of these neoplasms. Methods: A wide literature search of the PubMed\/MEDLINE, Scopus, and Cochrane Library databases was made to find relevant published articles on the role of [18F]FDG PET-based radiomics and ML for the assessment of gliomas and GBMs. Results: Eight studies were included in the systematic review. Signatures, including radiomics analysis and ML, generally demonstrated a possible diagnostic value to assess different characteristics of gliomas and GBMs, such as the methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter, the isocitrate dehydrogenase (IDH) genotype, alpha thalassemia\/mental retardation X-linked (ATRX) mutation status, proliferative activity, differential diagnosis with solitary brain metastases or primary central nervous system lymphoma, and prognosis of these patients. Conclusion: Despite some intrinsic limitations of radiomics and ML affecting the studies included in the review, some initial insights on the promising role of these technologies for the assessment of gliomas and GBMs are emerging. Validation of these preliminary findings in multicentric studies is needed to translate radiomics and ML approaches in the clinical setting.<\/jats:p>","DOI":"10.3390\/info16010058","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T06:46:10Z","timestamp":1737009970000},"page":"58","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["[18F]FDG PET-Based Radiomics and Machine Learning for the Assessment of Gliomas and Glioblastomas: A Systematic Review"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4839-9033","authenticated-orcid":false,"given":"Francesco","family":"Dondi","sequence":"first","affiliation":[{"name":"Nuclear Medicine, Universit\u00e0 Degli Studi di Brescia and ASST Spedali Civili di Brescia, 25123 Brescia, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4716-9925","authenticated-orcid":false,"given":"Roberto","family":"Gatta","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Cliniche e Sperimentali, Universit\u00e0 degli Studi di Brescia, 25123 Brescia, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8289-2054","authenticated-orcid":false,"given":"Maria","family":"Gazzilli","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, ASL Bari\u2014P.O. Di Venere, 70012 Bari, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3599-0492","authenticated-orcid":false,"given":"Pietro","family":"Bellini","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, ASST Spedali Civili di Brescia, 25123 Brescia, Italy"}]},{"given":"Gian Luca","family":"Vigan\u00f2","sequence":"additional","affiliation":[{"name":"Clinical Engineering, ASST Spedali Civili di Brescia, 25123 Brescia, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0168-8551","authenticated-orcid":false,"given":"Cristina","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Section of Nuclear Medicine, Interdisciplinary Department of Medicine, University of Bari \u201cAldo Moro\u201d, Piazza Giulio Cesare 11, 70124 Bari, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3335-9541","authenticated-orcid":false,"given":"Antonio Rosario","family":"Pisani","sequence":"additional","affiliation":[{"name":"Section of Nuclear Medicine, Interdisciplinary Department of Medicine, University of Bari \u201cAldo Moro\u201d, Piazza Giulio Cesare 11, 70124 Bari, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1972-3308","authenticated-orcid":false,"given":"Giuseppe","family":"Rubini","sequence":"additional","affiliation":[{"name":"Section of Nuclear Medicine, Interdisciplinary Department of Medicine, University of Bari \u201cAldo Moro\u201d, Piazza Giulio Cesare 11, 70124 Bari, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2980-5964","authenticated-orcid":false,"given":"Francesco","family":"Bertagna","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, Universit\u00e0 Degli Studi di Brescia and ASST Spedali Civili di Brescia, 25123 Brescia, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s13311-017-0519-x","article-title":"Glioma Subclassifications and Their Clinical Significance","volume":"14","author":"Chen","year":"2017","journal-title":"Neurotherapeutics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s11060-015-1909-8","article-title":"The role of neuropathology in the management of patients with diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline","volume":"125","author":"Cahill","year":"2015","journal-title":"J. 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