{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T10:16:50Z","timestamp":1776248210001,"version":"3.50.1"},"reference-count":92,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Information"],"abstract":"<jats:p>Autonomous supply chains (ASC) are the next generation of digitally empowered logistics and operations systems that can make adaptive, data-driven, and intelligent decisions. Innovations in artificial intelligence (AI), digital twins (DT), and predictive analytics (PA) are transforming traditional supply chains into integrated and interactive networks to detect disruptions, simulate the future, and automatically modify operational decisions. This paper reviews the ASC mechanism and summarizes the increasing literature on the technologies and analytical capabilities available to support intelligent supply chain decision systems. A structured literature review was conducted using Scopus, Web of Science, and Google Scholar, resulting in 52 relevant studies after screening and eligibility assessment. The paper discusses the recent advances in AI-based forecasting, simulation environments using digital twins, data integration using the Internet of Things (IoT), and predictive analytics. These technologies can help an organization gain real-time visibility of the supply chain networks. They improve the precision of demand forecasting, optimize inventory and production planning, and dynamically coordinate logistics operations. Digital twins allow the development of virtual models of supply chain ecosystems, which could be used to test scenarios, analyze risks, and plan strategies. These capabilities combined can be used to create predictive and self-adaptive supply networks capable of being responsive to uncertainty and market volatility. Besides examining the technological foundations, the paper also tracks key challenges related to the move towards autonomous supply chains, such as data governance, system interoperability, cybersecurity risks, algorithm transparency, and the necessity of successful human-AI collaboration in decision-making. The synthesis leads to a multi-layered framework that integrates data acquisition, analytics, simulation, and execution for autonomous decision-making in supply chains. Future research directions in relation to resilient supply networks, intelligent automation, and adaptive supply chain ecosystems are also provided in the study. Through integrating existing information on the new forms of intelligent technology and how it can be incorporated into the supply chain systems, this review contributes to the literature on next-generation supply chains. It will also offer information to both researchers and practitioners aiming at designing autonomous as well as data-driven supply networks.<\/jats:p>","DOI":"10.3390\/info17040371","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T09:15:59Z","timestamp":1776244559000},"page":"371","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Autonomous Supply Chains: Integrating Artificial Intelligence, Digital Twins, and Predictive Analytics for Intelligent Decision Systems"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9509-9060","authenticated-orcid":false,"given":"Mohammad","family":"Shamsuddoha","sequence":"first","affiliation":[{"name":"School of Accounting and Business Administration, Western Illinois University, Macomb, IL 61455, USA"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3031-9377","authenticated-orcid":false,"given":"Honey","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"School of Accounting and Business Administration, Western Illinois University, Macomb, IL 61455, USA"}]},{"given":"Tasnuba","family":"Nasir","sequence":"additional","affiliation":[{"name":"School of Business, Quincy University, Quincy, IL 62301, USA"}]},{"given":"Md Najmus","family":"Sakib","sequence":"additional","affiliation":[{"name":"Hutton School of Business, University of the Cumberlands, 6984 College Station Drive, Williamsburg, KY 40769, USA"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1080\/09537287.2020.1768450","article-title":"A digital supply chain twin for managing the disruption risks and resilience in the era of Industry 4.0","volume":"32","author":"Ivanov","year":"2021","journal-title":"Prod. 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