{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:31:00Z","timestamp":1760146260915,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020 research and innovation program","award":["968430","2020-1.1.5-GYORS\u00cdT\u00d3S\u00c1V-2021-00018","KDP-14-3\/PALY-2021"],"award-info":[{"award-number":["968430","2020-1.1.5-GYORS\u00cdT\u00d3S\u00c1V-2021-00018","KDP-14-3\/PALY-2021"]}]},{"DOI":"10.13039\/501100003827","name":"Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund","doi-asserted-by":"publisher","award":["968430","2020-1.1.5-GYORS\u00cdT\u00d3S\u00c1V-2021-00018","KDP-14-3\/PALY-2021"],"award-info":[{"award-number":["968430","2020-1.1.5-GYORS\u00cdT\u00d3S\u00c1V-2021-00018","KDP-14-3\/PALY-2021"]}],"id":[{"id":"10.13039\/501100003827","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Imaging"],"abstract":"<jats:p>The evaluation of hemodynamic conditions in critical limb-threatening ischemia (CLTI) patients is inevitable in endovascular interventions. In this study, the performance of color-coded digital subtraction angiography (ccDSA) and the recently developed color-coded digital variance angiography (ccDVA) was compared in the assessment of key time parameters in lower extremity interventions. The observational study included 19 CLTI patients who underwent peripheral vascular intervention at our institution in 2020. Pre- and post-dilatational images were retrospectively processed and analyzed by a commercially available ccDSA software (Kinepict Medical Imaging Tool 6.0.3; Kinepict Health Ltd., Budapest, Hungary) and by the recently developed ccDVA technology. Two protocols were applied using both a 4 and 7.5 frames per second acquisition rate. Time-to-peak (TTP) parameters were determined in four pre- and poststenotic regions of interest (ROI), and ccDVA values were compared to ccDSA read-outs. The ccDVA technology provided practically the same TTP values as ccDSA (r = 0.99, R2 = 0.98, p &lt; 0.0001). The correlation was extremely high independently of the applied protocol or the position of ROI; the r value was 0.99 (R2 = 0.98, p &lt; 0.0001) in all groups. A similar correlation was observed in the change in passage time (r = 0.98, R2 = 0.96, p &lt; 0.0001). The color-coded DVA technology can reproduce the same hemodynamic data as a commercially available DSA-based software; therefore, it has the potential to be an alternative decision-supporting tool in catheter labs.<\/jats:p>","DOI":"10.3390\/jimaging10100260","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T06:46:52Z","timestamp":1729234012000},"page":"260","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative Comparison of Color-Coded Parametric Imaging Technologies Based on Digital Subtraction and Digital Variance Angiography: A Retrospective Observational Study"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6346-1408","authenticated-orcid":false,"given":"Istv\u00e1n","family":"G\u00f3g","sequence":"first","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Heart and Vascular Center, Semmelweis University, V\u00e1rosmajor utca 68, 1122 Budapest, Hungary"},{"name":"Kinepict Health Ltd., Szil\u00e1gyi Erzs\u00e9bet fasor 31, 1027 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"S\u00f3tonyi","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Heart and Vascular Center, Semmelweis University, V\u00e1rosmajor utca 68, 1122 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8265-8671","authenticated-orcid":false,"given":"Bal\u00e1zs","family":"Nemes","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Heart and Vascular Center, Semmelweis University, V\u00e1rosmajor utca 68, 1122 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8734-1200","authenticated-orcid":false,"given":"J\u00e1nos P.","family":"Kiss","sequence":"additional","affiliation":[{"name":"Kinepict Health Ltd., Szil\u00e1gyi Erzs\u00e9bet fasor 31, 1027 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kriszti\u00e1n","family":"Szigeti","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Radiation Biology, Semmelweis University, T\u0171zolt\u00f3 u. 37-47, 1094 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szabolcs","family":"Osv\u00e1th","sequence":"additional","affiliation":[{"name":"Kinepict Health Ltd., Szil\u00e1gyi Erzs\u00e9bet fasor 31, 1027 Budapest, Hungary"},{"name":"Department of Biophysics and Radiation Biology, Semmelweis University, T\u0171zolt\u00f3 u. 37-47, 1094 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcell","family":"Gy\u00e1n\u00f3","sequence":"additional","affiliation":[{"name":"Kinepict Health Ltd., Szil\u00e1gyi Erzs\u00e9bet fasor 31, 1027 Budapest, Hungary"},{"name":"Department of Interventional Radiology, Heart and Vascular Center, Semmelweis University, V\u00e1rosmajor utca 68, 1122 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,18]]},"reference":[{"key":"ref_1","first-page":"547","article-title":"Interventional Radiology: Indications and Best Practices","volume":"99","author":"Arnold","year":"2019","journal-title":"Am. 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