{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T18:48:57Z","timestamp":1777142937669,"version":"3.51.4"},"reference-count":60,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union","award":["91"],"award-info":[{"award-number":["91"]}]},{"name":"European Union","award":["2021-063"],"award-info":[{"award-number":["2021-063"]}]},{"name":"Catalan Government","award":["91"],"award-info":[{"award-number":["91"]}]},{"name":"Catalan Government","award":["2021-063"],"award-info":[{"award-number":["2021-063"]}]},{"name":"AGAUR","award":["91"],"award-info":[{"award-number":["91"]}]},{"name":"AGAUR","award":["2021-063"],"award-info":[{"award-number":["2021-063"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Imaging"],"abstract":"<jats:p>The increasing use of high-resolution cross-sectional imaging has significantly enhanced the detection of pancreatic cystic lesions (PCLs), including pseudocysts and neoplastic entities such as IPMN, MCN, and SCN. However, accurate categorization of PCLs remains a challenge. This study aims to improve PCL evaluation by developing and validating a radiomics-based software tool leveraging machine learning (ML) for lesion classification. The model categorizes PCLs into mucinous and non-mucinous types using a custom dataset of 261 CT examinations, with 156 images for training and 105 for external validation. Three experienced radiologists manually delineated the images, extracting 38 radiological and 214 radiomic features using the Pyradiomics module in Python 3.13.2. Feature selection was performed using Least Absolute Shrinkage and Selection Operator (LASSO) regression, followed by classification with an Adaptive Boosting (AdaBoost) model trained on the optimized feature set. The proposed model achieved an accuracy of 89.3% in the internal validation cohort and demonstrated robust performance in the external validation cohort, with 90.2% sensitivity, 80% specificity, and 88.2% overall accuracy. Comparative analysis with existing radiomics-based studies showed that the proposed model either outperforms or performs on par with the current state-of-the-art methods, particularly in external validation scenarios. These findings highlight the potential of radiomics-driven machine learning approaches in enhancing PCL diagnosis across diverse patient populations.<\/jats:p>","DOI":"10.3390\/jimaging11030068","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T06:39:07Z","timestamp":1740119947000},"page":"68","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Machine Learning-Driven Radiomics Analysis for Distinguishing Mucinous and Non-Mucinous Pancreatic Cystic Lesions: A Multicentric Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Neus","family":"Torra-Ferrer","sequence":"first","affiliation":[{"name":"Department of Radiology, Hospital of Matar\u00f3 (Consorci Sanitari del Maresme), C\/ Cirera 230, 08304 Matar\u00f3, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Montserrat","family":"Duh","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital of Matar\u00f3 (Consorci Sanitari del Maresme), C\/ Cirera 230, 08304 Matar\u00f3, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Queralt","family":"Grau-Ortega","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital Universitari de Girona Josep Trueta, Avinguda de Fran\u00e7a, S\/N, 17007 Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Ca\u00f1adas-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Scientific and Technical Department, Sycai Technologies S.L., C\/ Llacuna 162, 2nd Floor, 08018 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Moreno-Vedia","sequence":"additional","affiliation":[{"name":"Scientific and Technical Department, Sycai Technologies S.L., C\/ Llacuna 162, 2nd Floor, 08018 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meritxell","family":"Riera-Mar\u00edn","sequence":"additional","affiliation":[{"name":"Scientific and Technical Department, Sycai Technologies S.L., C\/ Llacuna 162, 2nd Floor, 08018 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9219-5420","authenticated-orcid":false,"given":"Melanie","family":"Aliaga-Lavrijsen","sequence":"additional","affiliation":[{"name":"Scientific and Technical Department, Sycai Technologies S.L., C\/ Llacuna 162, 2nd Floor, 08018 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6554-9913","authenticated-orcid":false,"given":"Mateu","family":"Serra-Prat","sequence":"additional","affiliation":[{"name":"Research Unit, Hospital de Matar\u00f3 (Consorci Sanitari del Maresme), C\/ Cirera 230, 08304 Matar\u00f3, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9241-8479","authenticated-orcid":false,"given":"Javier","family":"Garc\u00eda L\u00f3pez","sequence":"additional","affiliation":[{"name":"Scientific and Technical Department, Sycai Technologies S.L., C\/ Llacuna 162, 2nd Floor, 08018 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9227-6826","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Gonz\u00e1lez-Ballester","sequence":"additional","affiliation":[{"name":"BCN MedTech, Universitat Pompeu Fabra (UPF), Edificio T\u00e0nger (Campus de Comunicaci\u00f3 Poblenou), C\/ T\u00e0nger 122-140, 08018 Barcelona, Spain"},{"name":"Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluis Companys 23, 08010 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8224-0037","authenticated-orcid":false,"given":"Maria Teresa","family":"Fern\u00e1ndez-Planas","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital of Matar\u00f3 (Consorci Sanitari del Maresme), C\/ Cirera 230, 08304 Matar\u00f3, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4788-6668","authenticated-orcid":false,"given":"J\u00falia","family":"Rodr\u00edguez-Comas","sequence":"additional","affiliation":[{"name":"Scientific and Technical Department, Sycai Technologies S.L., C\/ Llacuna 162, 2nd Floor, 08018 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"802","DOI":"10.2214\/AJR.07.3340","article-title":"Prevalence of unsuspected pancreatic cysts on MDCT","volume":"191","author":"Laffan","year":"2008","journal-title":"American J. 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