{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T09:15:39Z","timestamp":1775898939242,"version":"3.50.1"},"reference-count":15,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Imaging"],"abstract":"<jats:p>This study assesses the clinical deployment of SubtlePET\u2122, a commercial AI-based denoising algorithm, across three radiotracers\u201418F-FDG, 68Ga-PSMA-11, and 18F-FDOPA\u2014with the goal of improving image quality while reducing injected activity, technologist radiation exposure, and scan time. A retrospective analysis on a digital PET\/CT system showed that SubtlePET\u2122 enabled dose reductions exceeding 33% and time savings of over 25%. AI-enhanced images were rated interpretable in 100% of cases versus 65% for standard low-dose reconstructions. Notably, 85% of AI-enhanced scans received the maximum Likert quality score (5\/5), indicating excellent diagnostic confidence and noise suppression, compared to only 50% with conventional reconstruction. The quantitative image quality improved significantly across all tracers, with SNR and CNR gains of 50\u201370%. Radiotracer dose reductions were particularly substantial in low-BMI patients (up to 41% for FDG), and the technologist exposure decreased for high-exposure roles. The daily patient throughput increased by an average of 4.84 cases. These findings support the robust integration of SubtlePET\u2122 into routine clinical PET practice, offering improved efficiency, safety, and image quality without compromising lesion detectability.<\/jats:p>","DOI":"10.3390\/jimaging11070234","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T10:26:53Z","timestamp":1752229613000},"page":"234","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Implantation of an Artificial Intelligence Denoising Algorithm Using SubtlePET\u2122 with Various Radiotracers: 18F-FDG, 68Ga PSMA-11 and 18F-FDOPA, Impact on the Technologist Radiation Doses"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8451-2094","authenticated-orcid":false,"given":"Jules","family":"Zhang-Yin","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Centre National PET, Centre Hospitalier de Luxembourg, 4 Rue Ernest Barbl\u00e9, L-1210 Luxembourg, Luxembourg"}]},{"given":"Octavian","family":"Dragusin","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, Centre Hospitalier de Luxembourg, 4 Rue Ernest Barbl\u00e9, L-1210 Luxembourg, Luxembourg"}]},{"given":"Paul","family":"Jonard","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Centre National PET, Centre Hospitalier de Luxembourg, 4 Rue Ernest Barbl\u00e9, L-1210 Luxembourg, Luxembourg"}]},{"given":"Christian","family":"Picard","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Centre National PET, Centre Hospitalier de Luxembourg, 4 Rue Ernest Barbl\u00e9, L-1210 Luxembourg, Luxembourg"}]},{"given":"Justine","family":"Grangeret","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Centre National PET, Centre Hospitalier de Luxembourg, 4 Rue Ernest Barbl\u00e9, L-1210 Luxembourg, Luxembourg"}]},{"given":"Christopher","family":"Bonnier","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Centre National PET, Centre Hospitalier de Luxembourg, 4 Rue Ernest Barbl\u00e9, L-1210 Luxembourg, Luxembourg"}]},{"given":"Philippe P.","family":"Leveque","sequence":"additional","affiliation":[{"name":"Department of Radiopharmacy, Centre Hospitalier de Luxembourg, 4 Rue Ernest Barbl\u00e9, L-1210 Luxembourg, Luxembourg"}]},{"given":"Joel","family":"Aerts","sequence":"additional","affiliation":[{"name":"Department of Radiopharmacy, Centre Hospitalier de Luxembourg, 4 Rue Ernest Barbl\u00e9, L-1210 Luxembourg, Luxembourg"}]},{"given":"Olivier","family":"Schaeffer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Centre National PET, Centre Hospitalier de Luxembourg, 4 Rue Ernest Barbl\u00e9, L-1210 Luxembourg, Luxembourg"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nrc882","article-title":"Molecular imaging of cancer with positron emission tomography","volume":"2","author":"Gambhir","year":"2002","journal-title":"Nat. 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