{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T01:04:45Z","timestamp":1769303085482,"version":"3.49.0"},"reference-count":55,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020884","name":"ANID","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Radiology Department of the University of Chile Clinical Hospital"},{"name":"Clinical Research Support Office"},{"DOI":"10.13039\/501100005853","name":"University of Chile","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005853","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Imaging"],"abstract":"<jats:p>Prostate cancer (PCa) is the most common malignancy in men worldwide. Multiparametric MRI (mpMRI) improves the detection of clinically significant PCa (csPCa); however, it remains limited by false-positive findings and inter-observer variability. Time-dependent diffusion (TDD) MRI provides microstructural information that may enhance csPCa characterization beyond standard mpMRI. This prospective observational diagnostic accuracy study protocol describes the evaluation of PROS-TD-AI, an in-house developed AI workflow integrating TDD-derived metrics for zone-aware csPCa risk prediction. PROS-TD-AI will be compared with PI-RADS v2.1 in routine clinical imaging using MRI-targeted prostate biopsy as the reference standard.<\/jats:p>","DOI":"10.3390\/jimaging12010053","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T18:35:56Z","timestamp":1769193356000},"page":"53","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non-Invasive Detection of Prostate Cancer with Novel Time-Dependent Diffusion MRI and AI-Enhanced Quantitative Radiological Interpretation: PROS-TD-AI"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6750-1518","authenticated-orcid":false,"given":"Baltasar","family":"Ramos","sequence":"first","affiliation":[{"name":"Radiology Department, Clinical Hospital of the University of Chile, University of Chile, Independencia 8380453, Chile"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4321-9699","authenticated-orcid":false,"given":"Cristian","family":"Garrido","sequence":"additional","affiliation":[{"name":"Radiology Department, Clinical Hospital of the University of Chile, University of Chile, Independencia 8380453, Chile"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6901-4432","authenticated-orcid":false,"given":"Paulette","family":"Narv\u00e1ez","sequence":"additional","affiliation":[{"name":"Urology Department, Cl\u00ednica D\u00e1vila, Santiago 8431657, Chile"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6122-1688","authenticated-orcid":false,"given":"Santiago","family":"Gelerstein Claro","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Medicine, University of Chile, Santiago 8380453, Chile"}]},{"given":"Haotian","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomedical Engineering of the Ministry of Education, College of Biomedical Engineering & Instrument Science, Zhejiang University, Yuquan Campus, 38 Zheda Road, Hangzhou 310027, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8369-6773","authenticated-orcid":false,"given":"Rafael","family":"Salvador","sequence":"additional","affiliation":[{"name":"Radiology Department, Hospital Clinic, Universitat de Barcelona, 170, 08036 Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0052-7649","authenticated-orcid":false,"given":"Constanza","family":"V\u00e1squez-Venegas","sequence":"additional","affiliation":[{"name":"Laboratory for Scientific Image Analysis SCIAN-Lab, Integrative Biology Program, Institute of Biomedical Sciences ICBM, Faculty of Medicine, University of Chile, Santiago 8380453, Chile"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4692-5194","authenticated-orcid":false,"given":"Iv\u00e1n","family":"Gallegos","sequence":"additional","affiliation":[{"name":"Pathology Department, Clinical Hospital of the University of Chile, University of Chile, Independencia 8380453, Chile"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0554-0324","authenticated-orcid":false,"given":"V\u00edctor","family":"Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Medical Technology Department, Faculty of Medicine, University of Chile, Santiago 8380453, Chile"}]},{"given":"Cristian","family":"Acevedo","sequence":"additional","affiliation":[{"name":"Urology Department, Clinical Hospital of the University of Chile, University of Chile, Independencia 8380453, Chile"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5531-2533","authenticated-orcid":false,"given":"Gonzalo","family":"C\u00e1rdenas","sequence":"additional","affiliation":[{"name":"Radiology Department, Clinical Hospital of the University of Chile, University of Chile, Independencia 8380453, Chile"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6835-6386","authenticated-orcid":false,"given":"Camilo G.","family":"Sotomayor","sequence":"additional","affiliation":[{"name":"Radiology Department, Clinical Hospital of the University of Chile, University of Chile, Independencia 8380453, Chile"},{"name":"Anatomy and Developmental Biology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago 8380453, Chile"},{"name":"Faculty of Medicine, San Sebasti\u00e1n University, Campus Los Leones, Santiago 7510157, Chile"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"#cr-split#-ref_1.1","unstructured":"International Agency for Research on Cancer (2025, July 23). 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