{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T15:19:47Z","timestamp":1773415187216,"version":"3.50.1"},"reference-count":22,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002655","name":"Terry Fox Foundation","doi-asserted-by":"publisher","award":["1115"],"award-info":[{"award-number":["1115"]}],"id":[{"id":"10.13039\/501100002655","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["2019-06846"],"award-info":[{"award-number":["2019-06846"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Imaging"],"abstract":"<jats:p>This study assessed the level of agreement between quantitative ultrasound (QUS) feature estimates derived from ultrasound images of breast tumors in women with locally advanced breast cancer (LABC) produced using a cart-based and a handheld ultrasound system. Thirty LABC patients receiving neoadjuvant chemotherapy were imaged at two separate times: a pre-treatment \u2018baseline\u2019 time point, and four weeks after the start of chemotherapy. Three sets of QUS features were produced using the reference phantom technique, one for each imaging time and a third set calculated by taking the differences in feature estimates between times. Cross-system statistical testing using the Wilcoxon signed-rank test was performed for each feature set to assess the level of feature estimate agreement between ultrasound systems. The Bland\u2013Altman method was employed to graphically assess feature sets for systematic skew. The range of p-values was 4.50 \u00d7 10\u221211 to 0.277 for the baseline features, 2.77 \u00d7 10\u22125 to 0.865 for the week 4 features, and 2.03 \u00d7 10\u22129 to 1 for the feature differences. For the feature differences, all five of the primary QUS features (MBF, SS, SI, ASD, AAC) were found to be in agreement between the two scanner types at the 5% confidence level. For the baseline feature set and week 4 feature set, 0 out of 5 and 3 out of 5 of the primary features were found to be in agreement, respectively. Of the 20 QUS texture features examined, the number and proportion of the total for each feature set which were found to have statistically significant similarity in their sample medians at the 5% confidence level were as follows: 2 out of 20 (10%) for the baseline features; 17 out of 20 (85%) for the week 4 features; and 12 out of 20 (60%) for the feature differences. The specific texture features found to be in agreement varied between QUS-specific feature sets. Overall, a moderate level of agreement between sets of feature differences produced using the two systems was demonstrated.<\/jats:p>","DOI":"10.3390\/jimaging12030129","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:12:25Z","timestamp":1773400345000},"page":"129","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative Ultrasound Texture Analysis of Breast Tumor Responses to Chemotherapy: Comparison of a Cart-Based and a Wireless Ultrasound Scanner"],"prefix":"10.3390","volume":"12","author":[{"given":"David","family":"Alberico","sequence":"first","affiliation":[{"name":"Physical Sciences, Sunnybrook Research Institute, Toronto, ON M4N 0A4, Canada"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5588-9730","authenticated-orcid":false,"given":"Maria Lourdes Anzola","family":"Pena","sequence":"additional","affiliation":[{"name":"Physical Sciences, Sunnybrook Research Institute, Toronto, ON M4N 0A4, Canada"}]},{"given":"Laurentius O.","family":"Osapoetra","sequence":"additional","affiliation":[{"name":"Physical Sciences, Sunnybrook Research Institute, Toronto, ON M4N 0A4, Canada"}]},{"given":"Lakshmanan","family":"Sannachi","sequence":"additional","affiliation":[{"name":"Physical Sciences, Sunnybrook Research Institute, Toronto, ON M4N 0A4, Canada"}]},{"given":"Joyce","family":"Yip","sequence":"additional","affiliation":[{"name":"Physical Sciences, Sunnybrook Research Institute, Toronto, ON M4N 0A4, Canada"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8993-1327","authenticated-orcid":false,"given":"Sonal","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON M4N 0A4, Canada"},{"name":"Department of Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada"}]},{"given":"Frances","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Division of Surgical Oncology, Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, ON M4N 0A4, Canada"},{"name":"Department of Surgery, University of Toronto, Toronto, ON M5S 1A1, Canada"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3099-7425","authenticated-orcid":false,"given":"Michael","family":"Oelze","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Champaign, IL 61801, USA"}]},{"given":"Gregory J.","family":"Czarnota","sequence":"additional","affiliation":[{"name":"Physical Sciences, Sunnybrook Research Institute, Toronto, ON M4N 0A4, Canada"},{"name":"Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON M4N 0A4, Canada"},{"name":"Department of Medical Biophysics, University of Toronto, Toronto, ON M5S 1A1, Canada"},{"name":"Department of Radiation Oncology, University of Toronto, Toronto, ON M5S 1A1, Canada"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100827","DOI":"10.1016\/j.tranon.2020.100827","article-title":"Breast lesion characterization using Quantitative Ultrasound (QUS) and derivative texture methods","volume":"13","author":"Osapoetra","year":"2020","journal-title":"Transl. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5798","DOI":"10.1002\/cam4.3255","article-title":"Quantitative ultrasound radiomics in predicting response to neoadjuvant chemotherapy in patients with locally advanced breast cancer: Results from multi-institutional study","volume":"9","author":"DiCenzo","year":"2020","journal-title":"Cancer Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.tranon.2019.06.004","article-title":"Breast Cancer Treatment Response Monitoring Using Quantitative Ultrasound and Texture Analysis: Comparative Analysis of Analytical Models","volume":"12","author":"Sannachi","year":"2019","journal-title":"Transl. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.7863\/jum.2010.29.7.1117","article-title":"Cross-Imaging Platform Comparison of Ultrasonic Backscatter Coefficient Measurements of Live Rat Tumors","volume":"29","author":"Wirtzfeld","year":"2010","journal-title":"J. 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