{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:30:39Z","timestamp":1787844639536,"version":"build-2784847793"},"reference-count":152,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T00:00:00Z","timestamp":1631923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Imaging"],"abstract":"<jats:p>Breast cancer is one of the most common death causes amongst women all over the world. Early detection of breast cancer plays a critical role in increasing the survival rate. Various imaging modalities, such as mammography, breast MRI, ultrasound and thermography, are used to detect breast cancer. Though there is a considerable success with mammography in biomedical imaging, detecting suspicious areas remains a challenge because, due to the manual examination and variations in shape, size, other mass morphological features, mammography accuracy changes with the density of the breast. Furthermore, going through the analysis of many mammograms per day can be a tedious task for radiologists and practitioners. One of the main objectives of biomedical imaging is to provide radiologists and practitioners with tools to help them identify all suspicious regions in a given image. Computer-aided mass detection in mammograms can serve as a second opinion tool to help radiologists avoid running into oversight errors. The scientific community has made much progress in this topic, and several approaches have been proposed along the way. Following a bottom-up narrative, this paper surveys different scientific methodologies and techniques to detect suspicious regions in mammograms spanning from methods based on low-level image features to the most recent novelties in AI-based approaches. Both theoretical and practical grounds are provided across the paper sections to highlight the pros and cons of different methodologies. The paper\u2019s main scope is to let readers embark on a journey through a fully comprehensive description of techniques, strategies and datasets on the topic.<\/jats:p>","DOI":"10.3390\/jimaging7090190","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T08:04:23Z","timestamp":1632211463000},"page":"190","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["A Bottom-Up Review of Image Analysis Methods for Suspicious Region Detection in Mammograms"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9637-6157","authenticated-orcid":false,"given":"Parita","family":"Oza","sequence":"first","affiliation":[{"name":"Computer Science and Engineering Department, School of Technology, Pandit Deendayal Energy University, Gandhinagar 382007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paawan","family":"Sharma","sequence":"additional","affiliation":[{"name":"Computer Science and Engineering Department, School of Technology, Pandit Deendayal Energy University, Gandhinagar 382007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Patel","sequence":"additional","affiliation":[{"name":"Computer Science and Engineering Department, School of Technology, Pandit Deendayal Energy University, Gandhinagar 382007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0707-6131","authenticated-orcid":false,"given":"Alessandro","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Computing and Informatics, Bournemouth University, Poole, Dorset BH12 5BB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,18]]},"reference":[{"key":"ref_1","unstructured":"Society, A.C. 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