{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:47:41Z","timestamp":1760150861643,"version":"build-2065373602"},"reference-count":47,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T00:00:00Z","timestamp":1642896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Imaging"],"abstract":"<jats:p>The TRIMAGE project aims to develop a brain-dedicated PET\/MR\/EEG (Positron Emission Tomography\/Magnetic Resonance\/Electroencephalogram) system that is able to perform simultaneous PET, MR and EEG acquisitions. The PET component consists of a full ring with 18 sectors. Each sector includes three square detector modules based on dual sstaggered LYSO:Ce matrices read out by SiPMs. Using Monte Carlo simulations and following NEMA (National Electrical Manufacturers Association) guidelines, image quality procedures have been applied to evaluate the performance of the PET component of the system. The performance are reported in terms of spatial resolution, uniformity, recovery coefficient, spill over ratio, noise equivalent count rate (NECR) and scatter fraction. The results show that the TRIMAGE system is at the top of the current brain PET technologies.<\/jats:p>","DOI":"10.3390\/jimaging8020021","type":"journal-article","created":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T20:32:52Z","timestamp":1642969972000},"page":"21","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Monte Carlo Characterization of the Trimage Brain PET System"],"prefix":"10.3390","volume":"8","author":[{"given":"Luigi","family":"Masturzo","sequence":"first","affiliation":[{"name":"Department of Physics \u201cE. Fermi\u201d, University of Pisa, 56127 Pisa, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3100-9916","authenticated-orcid":false,"given":"Pietro","family":"Carra","sequence":"additional","affiliation":[{"name":"Department of Physics \u201cE. Fermi\u201d, University of Pisa, 56127 Pisa, Italy"},{"name":"National Institute of Nuclear Physics (INFN), Pisa Section, 56127 Pisa, Italy"}]},{"given":"Paola Anna","family":"Erba","sequence":"additional","affiliation":[{"name":"Department of Translational Research and New Technology in Medicine and Surgery, Regional Center of Nuclear Medicine, Azienda Ospedaliero Universitaria Pisana, University of Pisa, 56126 Pisa, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6636-3849","authenticated-orcid":false,"given":"Matteo","family":"Morrocchi","sequence":"additional","affiliation":[{"name":"Department of Physics \u201cE. Fermi\u201d, University of Pisa, 56127 Pisa, Italy"},{"name":"National Institute of Nuclear Physics (INFN), Pisa Section, 56127 Pisa, Italy"}]},{"given":"Alessandro","family":"Pilleri","sequence":"additional","affiliation":[{"name":"Department of Physics \u201cE. Fermi\u201d, University of Pisa, 56127 Pisa, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9982-0292","authenticated-orcid":false,"given":"Giancarlo","family":"Sportelli","sequence":"additional","affiliation":[{"name":"Department of Physics \u201cE. Fermi\u201d, University of Pisa, 56127 Pisa, Italy"},{"name":"National Institute of Nuclear Physics (INFN), Pisa Section, 56127 Pisa, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7648-9450","authenticated-orcid":false,"given":"Nicola","family":"Belcari","sequence":"additional","affiliation":[{"name":"Department of Physics \u201cE. Fermi\u201d, University of Pisa, 56127 Pisa, Italy"},{"name":"National Institute of Nuclear Physics (INFN), Pisa Section, 56127 Pisa, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,23]]},"reference":[{"key":"ref_1","first-page":"202","article-title":"The Development, Past Achievements, and Future Directions of Brain PET","volume":"21","author":"Jones","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_2","first-page":"1426","article-title":"Novel positron emission tomography radiotracers in brain tumor imaging","volume":"32","author":"Sharma","year":"2011","journal-title":"Indian J. Radiol. 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