{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:54:26Z","timestamp":1770818066059,"version":"3.50.1"},"reference-count":27,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Markus Rauh\/ETH Zurich Foundation Pioneer Fellowship PIO-07 16-2","award":["27785.1 PFLS-LS"],"award-info":[{"award-number":["27785.1 PFLS-LS"]}]},{"name":"Markus Rauh\/ETH Zurich Foundation Pioneer Fellowship PIO-07 16-2","award":["2018-HE-311"],"award-info":[{"award-number":["2018-HE-311"]}]},{"name":"Markus Rauh\/ETH Zurich Foundation Pioneer Fellowship PIO-07 16-2","award":["855292"],"award-info":[{"award-number":["855292"]}]},{"name":"Markus Rauh\/ETH Zurich Foundation Pioneer Fellowship PIO-07 16-2","award":["953844"],"award-info":[{"award-number":["953844"]}]},{"name":"Stephan Schmidheiny and Viktoria Schmidheiny and the ETH Zurich Foundation","award":["27785.1 PFLS-LS"],"award-info":[{"award-number":["27785.1 PFLS-LS"]}]},{"name":"Stephan Schmidheiny and Viktoria Schmidheiny and the ETH Zurich Foundation","award":["2018-HE-311"],"award-info":[{"award-number":["2018-HE-311"]}]},{"name":"Stephan Schmidheiny and Viktoria Schmidheiny and the ETH Zurich Foundation","award":["855292"],"award-info":[{"award-number":["855292"]}]},{"name":"Stephan Schmidheiny and Viktoria Schmidheiny and the ETH Zurich Foundation","award":["953844"],"award-info":[{"award-number":["953844"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation program","award":["27785.1 PFLS-LS"],"award-info":[{"award-number":["27785.1 PFLS-LS"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation program","award":["2018-HE-311"],"award-info":[{"award-number":["2018-HE-311"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation program","award":["855292"],"award-info":[{"award-number":["855292"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation program","award":["953844"],"award-info":[{"award-number":["953844"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Imaging"],"abstract":"<jats:p>NeuroLF is a dedicated brain PET system with an octagonal prism shape housed in a scanner head that can be positioned around a patient\u2019s head. Because it does not have MR or CT capabilities, attenuation correction based on an estimation of the attenuation map is a crucial feature. In this article, we demonstrate this method on [18F]FDG PET brain scans performed with a low-resolution proof of concept prototype of NeuroLF called BPET. We perform an affine registration of a template PET scan to the uncorrected emission image, and then apply the resulting transform to the corresponding template attenuation map. Using a whole-body PET\/CT system as reference, we quantitively show that this method yields comparable image quality (0.893 average correlation to reference scan) to using the reference \u00b5-map as obtained from the CT scan of the imaged patient (0.908 average correlation). We conclude from this initial study that attenuation correction using template registration instead of a patient CT delivers similar results and is an option for patients undergoing brain PET.<\/jats:p>","DOI":"10.3390\/jimaging9010002","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T06:11:24Z","timestamp":1671603084000},"page":"2","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Attenuation Correction Using Template PET Registration for Brain PET: A Proof-of-Concept Study"],"prefix":"10.3390","volume":"9","author":[{"given":"Markus","family":"Jehl","sequence":"first","affiliation":[{"name":"Positrigo AG, 8005 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina","family":"Mikhaylova","sequence":"additional","affiliation":[{"name":"Positrigo AG, 8005 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4584-3031","authenticated-orcid":false,"given":"Valerie","family":"Treyer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland"},{"name":"Institute for Regenerative Medicine, University of Zurich, 8006 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlena","family":"Hofbauer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4849-3292","authenticated-orcid":false,"given":"Martin","family":"H\u00fcllner","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp A.","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred","family":"Buck","sequence":"additional","affiliation":[{"name":"Positrigo AG, 8005 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoff","family":"Warnock","sequence":"additional","affiliation":[{"name":"PMOD Technologies LLC, 8117 Faellanden, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viet","family":"Dao","sequence":"additional","affiliation":[{"name":"Department of Statistics, School of Mathematics, University of Leeds, Leeds LS2 9JT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4971-2477","authenticated-orcid":false,"given":"Charalampos","family":"Tsoumpas","sequence":"additional","affiliation":[{"name":"Department of Statistics, School of Mathematics, University of Leeds, Leeds LS2 9JT, UK"},{"name":"Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2766-4339","authenticated-orcid":false,"given":"Daniel","family":"Deidda","sequence":"additional","affiliation":[{"name":"National Physical Laboratory, Teddington TW11 0LW, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5514-199X","authenticated-orcid":false,"given":"Kris","family":"Thielemans","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine, University College London, London NW1 2BU, UK"},{"name":"Centre for Medical Image Computing, UCL, Gower Street, London WC1E 6BT, UK"},{"name":"Algorithms Software Consulting Ltd., London SW15 5HX, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1000-0082","authenticated-orcid":false,"given":"Max Ludwig","family":"Ahnen","sequence":"additional","affiliation":[{"name":"Positrigo AG, 8005 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8329-0220","authenticated-orcid":false,"given":"Jannis","family":"Fischer","sequence":"additional","affiliation":[{"name":"Positrigo AG, 8005 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10334-012-0353-4","article-title":"MRI for Attenuation Correction in PET: Methods and Challenges","volume":"26","author":"Wagenknecht","year":"2013","journal-title":"Magn. 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