{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:41:16Z","timestamp":1782189676464,"version":"3.54.5"},"reference-count":38,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T00:00:00Z","timestamp":1679616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Imaging"],"abstract":"<jats:p>(1) The aim of our study is to evaluate the capacity of the Visually AcceSAble Rembrandt Images (VASARI) scoring system in discerning between the different degrees of glioma and Isocitrate Dehydrogenase (IDH) status predictions, with a possible application in machine learning. (2) A retrospective study was conducted on 126 patients with gliomas (M\/F = 75\/51; mean age: 55.30), from which we obtained their histological grade and molecular status. Each patient was analyzed with all 25 features of VASARI, blinded by two residents and three neuroradiologists. The interobserver agreement was assessed. A statistical analysis was conducted to evaluate the distribution of the observations using a box plot and a bar plot. We then performed univariate and multivariate logistic regressions and a Wald test. We also calculated the odds ratios and confidence intervals for each variable and the evaluation matrices with receiver operating characteristic (ROC) curves in order to identify cut-off values that are predictive of a diagnosis. Finally, we did the Pearson correlation test to see if the variables grade and IDH were correlated. (3) An excellent ICC estimate was obtained. For the grade and IDH status prediction, there were statistically significant results by evaluation of the degree of post-contrast impregnation (F4) and the percentage of impregnated area (F5), not impregnated area (F6), and necrotic (F7) tissue. These models showed good performances according to the area under the curve (AUC) values (&gt;70%). (4) Specific MRI features can be used to predict the grade and IDH status of gliomas, with important prognostic implications. The standardization and improvement of these data (aim: AUC &gt; 80%) can be used for programming machine learning software.<\/jats:p>","DOI":"10.3390\/jimaging9040075","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T06:34:07Z","timestamp":1679639647000},"page":"75","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Vasari Scoring System in Discerning between Different Degrees of Glioma and IDH Status Prediction: A Possible Machine Learning Application?"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0045-4673","authenticated-orcid":false,"given":"Laura","family":"Gemini","sequence":"first","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University \u201cFederico II\u201d, Via Pansini, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4745-3061","authenticated-orcid":false,"given":"Mario","family":"Tortora","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University \u201cFederico II\u201d, Via Pansini, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasqualina","family":"Giordano","sequence":"additional","affiliation":[{"name":"Oncology Unit, Ospedale del Mare ASL NA1 Centro, Via Enrico Russo, 80147 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Evelina","family":"Prudente","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, Ospedale del Mare ASL NA1 Centro, Via Enrico Russo, 80147 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Villa","sequence":"additional","affiliation":[{"name":"Neurosurgery Unit, Ospedale del Mare ASL NA1 Centro, Via Enrico Russo, 80147 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ottavia","family":"Vargas","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, Ospedale del Mare ASL NA1 Centro, Via Enrico Russo, 80147 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Francesca","family":"Giugliano","sequence":"additional","affiliation":[{"name":"Radiotherapy Unit, Ospedale del Mare ASL NA1 Centro, Via Enrico Russo, 80147 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8193-3050","authenticated-orcid":false,"given":"Francesco","family":"Somma","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, Ospedale del Mare ASL NA1 Centro, Via Enrico Russo, 80147 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Marchello","sequence":"additional","affiliation":[{"name":"CNRS, Laboratoire J.A. Dieudonn\u00e9, Inria, Universit\u00e8 C\u00f4te d\u2019Azur, Avenue Valrose, 06108 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela","family":"Chiaramonte","sequence":"additional","affiliation":[{"name":"Neurosurgery Unit, Ospedale del Mare ASL NA1 Centro, Via Enrico Russo, 80147 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella","family":"Gaetano","sequence":"additional","affiliation":[{"name":"Radiotherapy Unit, Ospedale del Mare ASL NA1 Centro, Via Enrico Russo, 80147 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Frio","sequence":"additional","affiliation":[{"name":"Neurosurgery Unit, Ospedale del Mare ASL NA1 Centro, Via Enrico Russo, 80147 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Di Giorgio","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Ospedale del Mare ASL NA1 Centro, Via Enrico Russo, 80147 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"D\u2019Avino","sequence":"additional","affiliation":[{"name":"Pathological Anatomy Unit, Ospedale del Mare ASL NA1 Centro, Via Enrico Russo, 80147 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Tortora","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University \u201cFederico II\u201d, Via Pansini, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"D\u2019Agostino","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, Ospedale del Mare ASL NA1 Centro, Via Enrico Russo, 80147 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7904-1563","authenticated-orcid":false,"given":"Alberto","family":"Negro","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, Ospedale del Mare ASL NA1 Centro, Via Enrico Russo, 80147 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1001\/jama.2013.280319","article-title":"Glioblastoma and other malignant gliomas: A clinical review","volume":"310","author":"Omuro","year":"2013","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1126\/science.1164382","article-title":"An integrated genomic analysis of human glioblastoma multiforme","volume":"321","author":"Parsons","year":"2008","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO Classification of Tumors of the Central Nervous System: A summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1056\/NEJMoa0808710","article-title":"IDH1 and IDH2 mutations in gliomas","volume":"360","author":"Yan","year":"2009","journal-title":"N. 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