{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T08:07:11Z","timestamp":1782461231314,"version":"3.54.5"},"reference-count":31,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FMTHH","award":["01fmthh2021"],"award-info":[{"award-number":["01fmthh2021"]}]},{"name":"Hamburg University of Technology (TUHH)","award":["01fmthh2021"],"award-info":[{"award-number":["01fmthh2021"]}]},{"name":"University Medical Center Hamburg-Eppendorf (UKE)","award":["01fmthh2021"],"award-info":[{"award-number":["01fmthh2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Imaging"],"abstract":"<jats:p>Computed tomography (CT) is a widely used examination technique that usually requires a compromise between image quality and radiation exposure. Reconstruction algorithms aim to reduce radiation exposure while maintaining comparable image quality. Recently, unsupervised deep learning methods have been proposed for this purpose. In this study, a promising sparse-view reconstruction method (posterior temperature optimized Bayesian inverse model; POTOBIM) is tested for its clinical applicability. For this study, 17 whole-body CTs of deceased were performed. In addition to POTOBIM, reconstruction was performed using filtered back projection (FBP). An evaluation was conducted by simulating sinograms and comparing the reconstruction with the original CT slice for each case. A quantitative analysis was performed using peak signal-to-noise ratio (PSNR) and structural similarity index measure (SSIM). The quality was assessed visually using a modified Ludewig\u2019s scale. In the qualitative evaluation, POTOBIM was rated worse than the reference images in most cases. A partially equivalent image quality could only be achieved with 80 projections per rotation. Quantitatively, POTOBIM does not seem to benefit from more than 60 projections. Although deep learning methods seem suitable to produce better image quality, the investigated algorithm (POTOBIM) is not yet suitable for clinical routine.<\/jats:p>","DOI":"10.3390\/jimaging9090170","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T08:57:39Z","timestamp":1692781059000},"page":"170","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bayesian Reconstruction Algorithms for Low-Dose Computed Tomography Are Not Yet Suitable in Clinical Context"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8340-8559","authenticated-orcid":false,"given":"Inga","family":"Kniep","sequence":"first","affiliation":[{"name":"Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, 22529 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0262-2519","authenticated-orcid":false,"given":"Robin","family":"Mieling","sequence":"additional","affiliation":[{"name":"Institute for Medical Technology and Intelligent Systems, Hamburg University of Technology, 21073 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Gerling","sequence":"additional","affiliation":[{"name":"Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, 22529 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Schlaefer","sequence":"additional","affiliation":[{"name":"Institute for Medical Technology and Intelligent Systems, Hamburg University of Technology, 21073 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Heinemann","sequence":"additional","affiliation":[{"name":"Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, 22529 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Ondruschka","sequence":"additional","affiliation":[{"name":"Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, 22529 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1056\/NEJMra072149","article-title":"Computed tomography\u2014An increasing source of radiation exposure","volume":"357","author":"Brenner","year":"2007","journal-title":"New Engl. 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