{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:46:15Z","timestamp":1770839175345,"version":"3.50.1"},"reference-count":34,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T00:00:00Z","timestamp":1696636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Imaging"],"abstract":"<jats:p>Background: The identification of histopathology in metastatic non-seminomatous testicular germ cell tumors (TGCT) before post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND) holds significant potential to reduce treatment-related morbidity in young patients, addressing an important survivorship concern. Aim: To explore this possibility, we conducted a study investigating the role of computed tomography (CT) radiomics models that integrate clinical predictors, enabling personalized prediction of histopathology in metastatic non-seminomatous TGCT patients prior to PC-RPLND. In this retrospective study, we included a cohort of 122 patients. Methods: Using dedicated radiomics software, we segmented the targets and extracted quantitative features from the CT images. Subsequently, we employed feature selection techniques and developed radiomics-based machine learning models to predict histological subtypes. To ensure the robustness of our procedure, we implemented a 5-fold cross-validation approach. When evaluating the models\u2019 performance, we measured metrics such as the area under the receiver operating characteristic curve (AUC), sensitivity, specificity, precision, and F-score. Result: Our radiomics model based on the Support Vector Machine achieved an optimal average AUC of 0.945. Conclusions: The presented CT-based radiomics model can potentially serve as a non-invasive tool to predict histopathological outcomes, differentiating among fibrosis\/necrosis, teratoma, and viable tumor in metastatic non-seminomatous TGCT before PC-RPLND. It has the potential to be considered a promising tool to mitigate the risk of over- or under-treatment in young patients, although multi-center validation is critical to confirm the clinical utility of the proposed radiomics workflow.<\/jats:p>","DOI":"10.3390\/jimaging9100213","type":"journal-article","created":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T14:17:26Z","timestamp":1696688246000},"page":"213","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Radiomics Analyses to Predict Histopathology in Patients with Metastatic Testicular Germ Cell Tumors before Post-Chemotherapy Retroperitoneal Lymph Node Dissection"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9558-8086","authenticated-orcid":false,"given":"Anna","family":"Scavuzzo","sequence":"first","affiliation":[{"name":"Department of Uro-Oncology, Instituto Nacional de Cancerologia, Universidad Autonoma de Mexico-UNAM, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8750-0731","authenticated-orcid":false,"given":"Giovanni","family":"Pasini","sequence":"additional","affiliation":[{"name":"Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), 90015 Cefal\u00f9, Italy"},{"name":"Department of Mechanical and Aerospace Engineering, Sapienza University of Rome, Eudossiana 18, 00184 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7058-6391","authenticated-orcid":false,"given":"Elisabetta","family":"Crescio","sequence":"additional","affiliation":[{"name":"Science Department, Tecnol\u00f3gico de Monterrey, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Angel","family":"Jimenez-Rios","sequence":"additional","affiliation":[{"name":"Department of Uro-Oncology, Instituto Nacional de Cancerologia, Universidad Autonoma de Mexico-UNAM, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Figueroa-Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Instituto Nacional de Cancerologia,  Universidad Autonoma de Mexico-UNAM, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9290-6103","authenticated-orcid":false,"given":"Albert","family":"Comelli","sequence":"additional","affiliation":[{"name":"Ri.MED Foundation, Via Bandiera 11, 90133 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1493-1087","authenticated-orcid":false,"given":"Giorgio","family":"Russo","sequence":"additional","affiliation":[{"name":"Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), 90015 Cefal\u00f9, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan Calvo","family":"Vazquez","sequence":"additional","affiliation":[{"name":"Department of Uro-Oncology, Instituto Nacional de Cancerologia, Universidad Autonoma de Mexico-UNAM, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-9171","authenticated-orcid":false,"given":"Sebastian Muruato","family":"Araiza","sequence":"additional","affiliation":[{"name":"Department of Uro-Oncology, Instituto Nacional de Cancerologia, Universidad Autonoma de Mexico-UNAM, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2239-7064","authenticated-orcid":false,"given":"David Gomez","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Department of Uro-Oncology, Instituto Nacional de Cancerologia, Universidad Autonoma de Mexico-UNAM, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delia","family":"Perez Montiel","sequence":"additional","affiliation":[{"name":"Department of Pathology, Instituto Nacional de Cancerolog\u00eda, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3838-4738","authenticated-orcid":false,"given":"Alejandro","family":"Lopez Saavedra","sequence":"additional","affiliation":[{"name":"Advanced Microscopy Applications Unit (ADMiRA), Instituto Nacional de Cancerolog\u00eda, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7189-1731","authenticated-orcid":false,"given":"Alessandro","family":"Stefano","sequence":"additional","affiliation":[{"name":"Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), 90015 Cefal\u00f9, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e12390","DOI":"10.1097\/MD.0000000000012390","article-title":"Recent Global Trends in Testicular Cancer Incidence and Mortality","volume":"97","author":"Park","year":"2018","journal-title":"Medicine"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Yazici, S., Del Biondo, D., Napodano, G., Grillo, M., Calace, F.P., Prezioso, D., Crocetto, F., and Barone, B. 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