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Computer-aided diagnosis (CAD) powered by artificial intelligence (AI) is becoming increasingly prominent in disease diagnosis. CAD for multimodal medical data requires addressing the issues of data fusion and prediction. Traditionally, the prediction performance of CAD models has not been good enough due to the complicated dimensionality reduction. Therefore, this paper proposes a fusion and prediction model\u2014EPGC\u2014for multimodal medical data based on graph neural networks. Firstly, we select features from unstructured multimodal medical data and quantify them. Then, we transform the multimodal medical data into a graph data structure by establishing each patient as a node, and establishing edges based on the similarity of features between the patients. Normalization of data is also essential in this process. Finally, we build a node prediction model based on graph neural networks and predict the node classification, which predicts the patients\u2019 diseases. The model is validated on two publicly available datasets of heart diseases. Compared to the existing models that typically involve dimensionality reduction, classification, or the establishment of complex deep learning networks, the proposed model achieves outstanding results with the experimental dataset. This demonstrates that the fusion and diagnosis of multimodal data can be effectively achieved without dimension reduction or intricate deep learning networks. We take pride in exploring unstructured multimodal medical data using deep learning and hope to make breakthroughs in various fields.<\/jats:p>","DOI":"10.3390\/make7030092","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T16:05:22Z","timestamp":1756829122000},"page":"92","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Novel Prediction Model for Multimodal Medical Data Based on Graph Neural Networks"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2377-0636","authenticated-orcid":false,"given":"Lifeng","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Public Health, Peking University, Beijing 100871, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Cui","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Networking & Switching Technology, Beijing University of the Posts and Telecommunications, Beijing 100876, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Zhang","sequence":"additional","affiliation":[{"name":"International School, Beijing University of Posts and Telecommunications, Beijing 100876, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijie","family":"Jiang","sequence":"additional","affiliation":[{"name":"Petroleum Institute, China University of Petroleum (Beijing), Karamay Campus, Karamay 834000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiadong","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Networking & Switching Technology, Beijing University of the Posts and Telecommunications, Beijing 100876, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9038-1622","authenticated-orcid":false,"given":"Roy E.","family":"Welsch","sequence":"additional","affiliation":[{"name":"Sloan School of Management, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"},{"name":"Center for Statistics and Data Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongwei","family":"Jia","sequence":"additional","affiliation":[{"name":"School of Public Health, Peking University, Beijing 100871, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Jiang, S., Wang, T., and Zhang, K. 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