{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:27:53Z","timestamp":1773887273189,"version":"3.50.1"},"reference-count":39,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2012,5,10]],"date-time":"2012-05-10T00:00:00Z","timestamp":1336608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Micromachines"],"abstract":"<jats:p>Hydrodynamically confined flow device technology is a young research area with high practical application potential in surface processing, assay development, and in various areas of single cell research. Several variants have been developed, and most recently, theoretical and conceptual studies, as well as fully developed automated systems, were presented. In this article we review concepts, fabrication strategies, and application areas of hydrodynamically confined flow (HCF) devices.<\/jats:p>","DOI":"10.3390\/mi3020442","type":"journal-article","created":{"date-parts":[[2012,5,10]],"date-time":"2012-05-10T11:11:15Z","timestamp":1336648275000},"page":"442-461","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Hydrodynamic Flow Confinement Technology in Microfluidic Perfusion Devices"],"prefix":"10.3390","volume":"3","author":[{"given":"Alar","family":"Ainla","sequence":"first","affiliation":[{"name":"Department of Chemical and Biological Engineering, Chalmers University of Technology, Kemiv\u00e4gen 10, 412 96 G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin","family":"Jeffries","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering, Chalmers University of Technology, Kemiv\u00e4gen 10, 412 96 G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo","family":"Jesorka","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering, Chalmers University of Technology, Kemiv\u00e4gen 10, 412 96 G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2012,5,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1586\/erm.11.25","article-title":"Microfluidic devices for diagnostic applications","volume":"11","author":"Eicher","year":"2011","journal-title":"Expert Rev. 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