{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:51:12Z","timestamp":1773330672774,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T00:00:00Z","timestamp":1418169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Grant No.61404036"],"award-info":[{"award-number":["Grant No.61404036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Micromachines"],"abstract":"<jats:p>In this paper, we proposed a novel bonding technology to fabricate a microfluidic device based on Poly(methyl methacrylate) (PMMA). The method, which used chloroform and ethanol as miscible bonding solvent, can complete complex structures rapid assembly (10 min) at 40\u00b0C. A bonding strength of 267.5 N\/cm2 can be achieved, while the micro channel deformation was less than 7.26%. Then we utilized this method to produce a three layers micro mixer, which included a T-shaped inlet channel and six H-shaped mixing units. Numerical simulation indicated that, the well mixing length of the mixer was only about  6 mm when Re = 10. Finally, fluorescence microscopy was used to verify mixer performance. The method provided the potential for mass production of multilayer rigid polymer microfluidic devices.<\/jats:p>","DOI":"10.3390\/mi5041416","type":"journal-article","created":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T09:32:11Z","timestamp":1418203931000},"page":"1416-1428","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Miscible Organic Solvents Soak Bonding Method Use in a PMMA Multilayer Microfluidic Device"],"prefix":"10.3390","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0371-9507","authenticated-orcid":false,"given":"He","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Micro-Systems and Micro-Structures Manufacturing, Harbin Institute of Technology, Harbin 150001, China"}]},{"given":"Xiaowei","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Micro-Systems and Micro-Structures Manufacturing, Harbin Institute of Technology, Harbin 150001, China"}]},{"given":"Tian","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Micro-Systems and Micro-Structures Manufacturing, Harbin Institute of Technology, Harbin 150001, China"}]},{"given":"Xiaowei","family":"Han","sequence":"additional","affiliation":[{"name":"Key Laboratory of Micro-Systems and Micro-Structures Manufacturing, Harbin Institute of Technology, Harbin 150001, China"}]}],"member":"1968","published-online":{"date-parts":[[2014,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"012818","DOI":"10.1063\/1.3654950","article-title":"Integrated microfluidic chip for rapid DNA digestion and time-resolved capillary electrophoresis analysis","volume":"6","author":"Lin","year":"2012","journal-title":"Biomicrofluidics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s10404-013-1180-2","article-title":"Software programmable continuous flow multi-purpose lab on a chip","volume":"15","author":"Amin","year":"2013","journal-title":"Microfluid. Nanofluid."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.chroma.2013.04.066","article-title":"Microfluidic lab-on-a-chip derivatization for gaseous carbonyl analysis","volume":"1296","author":"Pang","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.snb.2009.05.007","article-title":"A novel microreactor with 3D rotating flow to boost fluid reaction and mixing of viscous fluids","volume":"140","author":"Fang","year":"2009","journal-title":"Sens. Actuators B Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s10404-010-0565-8","article-title":"Three-dimensional microfluidic chip for the extraction of mitochondrial DNA","volume":"9","author":"Chang","year":"2010","journal-title":"Microfluid. Nanofluid."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"095021","DOI":"10.1088\/0960-1317\/18\/9\/095021","article-title":"PMMA microfluidic devices with three-dimensional features for blood cell filtration","volume":"18","author":"Li","year":"2008","journal-title":"J. Micromech. Microeng."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"036502","DOI":"10.1063\/1.3641859","article-title":"Low cost fabrication and assembly process for re-usable 3D polydimethylsiloxane (PDMS) microfluidic networks","volume":"5","author":"Land","year":"2011","journal-title":"Biomicrofluidics"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4764","DOI":"10.1039\/c2lc40572e","article-title":"3D nanomolding for lab-on-a-chip applications","volume":"12","author":"Farshchian","year":"2012","journal-title":"Lab Chip"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.snb.2005.07.047","article-title":"Determination of EOF of PMMA microfluidic chip by indirect laser-induced fluorescence detection","volume":"114","author":"Chen","year":"2006","journal-title":"Sens. Actuators B Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1007\/s10404-010-0633-0","article-title":"Rapid prototyping of PMMA microfluidic chips utilizing a CO2 laser","volume":"9","author":"Hong","year":"2010","journal-title":"Microfluid. Nanofluid."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10404-008-0361-x","article-title":"Bonding of thermoplastic polymer microfluidics","volume":"6","author":"Tsao","year":"2009","journal-title":"Microfluid. Nanofluid."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3901\/CJME.2006.02.223","article-title":"Hot embossing methods for plastic microchannel fabrication","volume":"19","author":"Liu","year":"2006","journal-title":"Chin. J. Mechan. Eng. Engl. Ed."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"288","DOI":"10.4028\/www.scientific.net\/AMR.60-61.288","article-title":"Investigation of Thermal Bonding on PMMA Capillary Electrophoresis Chip","volume":"60","author":"Zhang","year":"2009","journal-title":"Adv. Mater. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ymeth.2005.07.004","article-title":"Fabrication of DNA microarrays onto polymer substrates using UV modification protocols with integration into microfluidic platforms for the sensing of low-abundant DNA point mutations","volume":"37","author":"Soper","year":"2005","journal-title":"Methods"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1039\/b618901f","article-title":"Low temperature bonding of PMMA and COC microfluidic substrates using UV\/ozone surface treatment","volume":"7","author":"Tsao","year":"2007","journal-title":"Lab Chip"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5097","DOI":"10.1021\/ac070220w","article-title":"Room-temperature bonding for plastic high-pressure microfluidic chips","volume":"79","author":"Mair","year":"2007","journal-title":"Anal. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s00542-009-0821-6","article-title":"Fabrication and testing of embedded microvalves within PMMA microfluidic devices","volume":"15","author":"Toh","year":"2009","journal-title":"Microsyst. Technol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.snb.2009.07.032","article-title":"Plasma assisted thermal bonding for PMMA microfluidic chips with integrated metal microelectrodes","volume":"141","author":"Liu","year":"2009","journal-title":"Sens. Actuators B Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5487","DOI":"10.1016\/j.jmatprotec.2009.05.003","article-title":"Multi-layer PMMA microfluidic chips with channel networks for liquid sample operation","volume":"209","author":"Li","year":"2009","journal-title":"J. Mater. Process. Technol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1039\/c004744a","article-title":"Wax-bonding 3D microfluidic chips","volume":"10","author":"Gong","year":"2010","journal-title":"Lab Chip"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.jmatprotec.2012.06.022","article-title":"Fabrication of a thermoplastic multilayer microfluidic chip","volume":"212","author":"Li","year":"2012","journal-title":"J. Mater. Process. Technol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.sna.2003.12.018","article-title":"Microwave bonding of polymer-based substrates for potential encapsulated micro\/nanofluidic device fabrication","volume":"114","author":"Lei","year":"2004","journal-title":"Sens. Actuators A Phys."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1088\/0960-1317\/15\/9\/011","article-title":"Microwave welding of polymeric-microfluidic devices","volume":"15","author":"Yussuf","year":"2005","journal-title":"J. Micromech. Microeng."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"015026","DOI":"10.1088\/0960-1317\/20\/1\/015026","article-title":"Microwave-induced, thermally assisted solvent bonding for low-cost PMMA microfluidic devices","volume":"20","author":"Rahbar","year":"2010","journal-title":"J. Micromech. Microeng."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.mee.2009.01.048","article-title":"Microfluidic connectors by ultrasonic welding","volume":"86","author":"Ng","year":"2009","journal-title":"Microelectron. Eng."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.talanta.2010.02.031","article-title":"Thermal assisted ultrasonic bonding method for poly(methyl methacrylate) (PMMA) microfluidic devices","volume":"81","author":"Zhang","year":"2010","journal-title":"Talanta"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1016\/j.mee.2010.04.020","article-title":"Ultrasonic bonding for thermoplastic microfluidic devices without energy director","volume":"87","author":"Luo","year":"2010","journal-title":"Microelectron. Eng."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1039\/B512179E","article-title":"Fabrication and characterization of poly (methylmethacrylate) microfluidic devices bonded using surface modifications and solvents","volume":"6","author":"Brown","year":"2006","journal-title":"Lab Chip"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s10544-007-9059-1","article-title":"Applying Taguchi methods for solvent-assisted PMMA bonding technique for static and dynamic \u03bc-TAS devices","volume":"9","author":"Hsu","year":"2007","journal-title":"Biomed. Microdevices"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.snb.2006.04.086","article-title":"Low azeotropic solvent for bonding of PMMA microfluidic devices","volume":"121","author":"Lin","year":"2007","journal-title":"Sens. Actuators B Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.sna.2009.03.028","article-title":"Solvent assisted bonding of polymethylmethacrylate: Characterization using the response surface methodology","volume":"156","author":"Umbrecht","year":"2009","journal-title":"Sens. Actuators A Phys."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.snb.2012.11.060","article-title":"Ethanol and UV-assisted instantaneous bonding of PMMA assemblies and tuning in bonding reversibility","volume":"181","author":"Tran","year":"2013","journal-title":"Sens. Actuators B Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10404-012-1035-2","article-title":"Solvent vapor treatment controls surface wettability in PMMA femtosecond-laser-ablated microchannels","volume":"14","author":"Eaton","year":"2013","journal-title":"Microfluid. 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