{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T21:32:30Z","timestamp":1783373550386,"version":"3.54.6"},"reference-count":26,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Micromachines"],"abstract":"<jats:p>Polydimethylsiloxane (PDMS) and SU-8 are currently two very commonly used polymeric materials in the microfluidics field for biological applications. However; there is a pressing need to find a simple, reliable, irreversible bonding method between these two materials for their combined use in innovative integrated microsystems. In this paper, we attempt to investigate the aminosilane-mediated irreversible bonding method for PDMS and SU-8 with X-Ray Photoelectron Spectroscopy (XPS) surface analysis and bonding strength tests. Additionally, the selected bonding method was applied in fabricating a microelectrode array (MEA) device, including microfluidic features, which allows electrophysiological observations on compartmentalized neuronal cultures. As there is a growing trend towards microfluidic devices for neuroscience research, this type of integrated microdevice, which can observe functional alterations on compartmentalized neuronal culture, can potentially be used for neurodegenerative disease research and pharmaceutical development.<\/jats:p>","DOI":"10.3390\/mi6121465","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T07:06:30Z","timestamp":1449644790000},"page":"1923-1934","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["A Simple and Reliable PDMS and SU-8 Irreversible Bonding Method and Its Application on a Microfluidic-MEA Device for Neuroscience Research"],"prefix":"10.3390","volume":"6","author":[{"given":"Yufei","family":"Ren","sequence":"first","affiliation":[{"name":"Microsystems Laboratory, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, EPFL-STI-IMT-LMIS4, Station 17, Lausanne 1015, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun-Ho","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, National Cheng Kung University, Tainan 70101, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Mosser","sequence":"additional","affiliation":[{"name":"Brain Mind Institute and School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, EPFL-SV-BMI-CMSN, Station 15, Lausanne 1015, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Heuschkel","sequence":"additional","affiliation":[{"name":"Qwane Biosciences SA, Lausanne 1015, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Bertsch","sequence":"additional","affiliation":[{"name":"Microsystems Laboratory, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, EPFL-STI-IMT-LMIS4, Station 17, Lausanne 1015, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Fraering","sequence":"additional","affiliation":[{"name":"Brain Mind Institute and School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, EPFL-SV-BMI-CMSN, Station 15, Lausanne 1015, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Jin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, National Cheng Kung University, Tainan 70101, Taiwan"},{"name":"Medical Device Innovation Center, National Cheng Kung University, Tainan 70101, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Renaud","sequence":"additional","affiliation":[{"name":"Microsystems Laboratory, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, EPFL-STI-IMT-LMIS4, Station 17, Lausanne 1015, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,12,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10544-005-6070-2","article-title":"Characterization of polydimethylsiloxane (PDMS) properties for biomedical micro\/nanosystems","volume":"7","author":"Mata","year":"2005","journal-title":"Biomed. 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