{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T07:39:27Z","timestamp":1769240367223,"version":"3.49.0"},"reference-count":27,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T00:00:00Z","timestamp":1459296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Rural Development Administration of Korea","award":["PJ009842"],"award-info":[{"award-number":["PJ009842"]}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2013R1A2A1A05006378"],"award-info":[{"award-number":["NRF-2013R1A2A1A05006378"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2011K000864"],"award-info":[{"award-number":["2011K000864"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Micromachines"],"abstract":"<jats:p>Droplet microfluidics is a promising tool for single-cell analysis since single cell can be comparted inside a tiny volume. However, droplet encapsulation of single cells still remains a challenging issue due to the low ratio of droplets containing single cells. Here, we introduce a simple and robust single cell sorting platform based on a magnetophoretic method using monodisperse magnetic nanoparticles (MNPs) and droplet microfluidics with &gt;94% purity. There is an approximately equal amount of MNPs in the same-sized droplet, which has the same magnetic force under the magnetic field. However, the droplets containing single cells have a reduced number of MNPs, as much as the volume of the cell inside the droplet, resulting in a low magnetic force. Based on this simple principle, this platform enables the separation of single cell-encapsulated droplets from the droplets with no cells. Additionally, this device uses only a permanent magnet without any complex additional apparatus; hence, this new platform can be integrated into a single cell analysis system considering its effectiveness and convenience.<\/jats:p>","DOI":"10.3390\/mi7040056","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T16:47:27Z","timestamp":1459356447000},"page":"56","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Magnetophoretic Sorting of Single Cell-Containing Microdroplets"],"prefix":"10.3390","volume":"7","author":[{"given":"Younggeun","family":"Jo","sequence":"first","affiliation":[{"name":"Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea"}]},{"given":"Fengshan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7112-6960","authenticated-orcid":false,"given":"Young","family":"Hahn","sequence":"additional","affiliation":[{"name":"Samsung Electronics, 4 Seocho-daero 74-gil, Seocho-gu, Seoul 06620, Republic of Korea"}]},{"given":"Ji-Ho","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4522-2574","authenticated-orcid":false,"given":"Je-Kyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea"}]}],"member":"1968","published-online":{"date-parts":[[2016,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/cyto.990120606","article-title":"Application of laser optical tweezers in immunology and molecular-genetics","volume":"12","author":"Seeger","year":"1991","journal-title":"Cytometry"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0955-3886(97)00018-0","article-title":"Methods of CD34+ cell separation: Comparative analysis","volume":"18","author":"Beaujean","year":"1997","journal-title":"Transfus. 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