{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:53:49Z","timestamp":1781312029348,"version":"3.54.1"},"reference-count":10,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Micromachines"],"abstract":"<jats:p>A plug-based microfluidic system based on the principle of the light-addressable potentiometric sensor (LAPS) is proposed. The LAPS is a semiconductor-based chemical sensor, which has a free addressability of the measurement point on the sensing surface. By combining a microfluidic device and LAPS, ion sensing can be performed anywhere inside the microfluidic channel. In this study, the sample solution to be measured was introduced into the channel in a form of a plug with a volume in the range of microliters. Taking advantage of the light-addressability, the position of the plug could be monitored and pneumatically controlled. With the developed system, the pH value of a plug with a volume down to 400 nL could be measured. As an example of plug-based operation, two plugs were merged in the channel, and the pH change was detected by differential measurement.<\/jats:p>","DOI":"10.3390\/mi7070111","type":"journal-article","created":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T09:51:48Z","timestamp":1467366708000},"page":"111","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Light-Addressable Potentiometric Sensor as a Sensing Element in Plug-Based Microfluidic Devices"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7889-6714","authenticated-orcid":false,"given":"Ko-Ichiro","family":"Miyamoto","sequence":"first","affiliation":[{"name":"Department of Electronic Engineering, Tohoku University, 6-6-05 Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering, Tohoku University, 6-6-05 Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minami","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering, Tohoku University, 6-6-05 Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Wagner","sequence":"additional","affiliation":[{"name":"Institute of Nano- and Biotechnologies, Aachen University of Applied Sciences, Heinrich-Mu\u00dfmann-Str. 1, J\u00fclich 52428, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4347-6685","authenticated-orcid":false,"given":"Michael","family":"Sch\u00f6ning","sequence":"additional","affiliation":[{"name":"Institute of Nano- and Biotechnologies, Aachen University of Applied Sciences, Heinrich-Mu\u00dfmann-Str. 1, J\u00fclich 52428, Germany"},{"name":"Peter-Gr\u00fcnberg Institute (PGI-8), Research Centre J\u00fclich, J\u00fclich 52425, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7993-716X","authenticated-orcid":false,"given":"Tatsuo","family":"Yoshinobu","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering, Tohoku University, 6-6-05 Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan"},{"name":"Department of Biomedical Engineering, Tohoku University, 6-6-05 Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nature04163","article-title":"Controlled microfluidic interfaces","volume":"437","author":"Atencia","year":"2005","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1039\/b510841a","article-title":"Formation of droplets and bubbles in a microfluidic T-junction-scaling and mechanism of break-up","volume":"6","author":"Garstecki","year":"2006","journal-title":"Lab Chip"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"7336","DOI":"10.1002\/anie.200601554","article-title":"Reactions in droplets in microfluidic channels","volume":"45","author":"Song","year":"2006","journal-title":"Angew. 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