{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:58:37Z","timestamp":1787029117469,"version":"build-2736575974"},"reference-count":65,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MTI"],"abstract":"<jats:p>Medicinal chemistry (MC) is an indispensable component of the pharmacy curriculum. The pharmacists\u2019 unique knowledge of a medicine\u2019s chemistry enhances their understanding of the pharmacological activity, manufacturing, storage, use, supply, and handling of drugs. However, chemistry is a challenging subject for both teaching and learning. These challenges are typically caused by the inability of students to construct a mental image of the three-dimensional (3D) structure of a drug molecule from its two-dimensional presentations. This study explores a prototype virtual reality (VR) gamification option, as an educational tool developed to aid the learning process and to improve the delivery of the MC subject to students. The developed system is evaluated by a cohort of 41 students. The analysis of the results was encouraging and provided invaluable feedback for the future development of the proposed system.<\/jats:p>","DOI":"10.3390\/mti5030010","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:39:07Z","timestamp":1614904747000},"page":"10","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["\u201cMedChemVR\u201d: A Virtual Reality Game to Enhance Medicinal Chemistry Education"],"prefix":"10.3390","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4978-5059","authenticated-orcid":false,"given":"Areej","family":"Abuhammad","sequence":"first","affiliation":[{"name":"School of Pharmacy, Department of Pharmaceutical Sciences, The University of Jordan, Amman 11942, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannat","family":"Falah","sequence":"additional","affiliation":[{"name":"Department of Autonomous Systems, Faculty of Artificial Intelligence, Al Balqa Applied University, Al Salt 19117, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salasabeel F. M.","family":"Alfalah","sequence":"additional","affiliation":[{"name":"King Abdullah II School of Information Technology, The University of Jordan, Amman 11942, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhannad","family":"Abu-Tarboush","sequence":"additional","affiliation":[{"name":"King Abdullah II School of Information Technology, The University of Jordan, Amman 11942, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruba T.","family":"Tarawneh","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Department of Pharmaceutical Sciences, The University of Jordan, Amman 11942, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Drikakis","sequence":"additional","affiliation":[{"name":"University of Nicosia, Nicosia CY-2417, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4195-843X","authenticated-orcid":false,"given":"Vassilis","family":"Charissis","sequence":"additional","affiliation":[{"name":"School of Computing, Engineering and Built Environment, Glasgow Caledonian University, Glasgow G4 0BA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6083","DOI":"10.5688\/ajpe6083","article-title":"The Importance of Medicinal Chemistry Knowledge in the Clinical Pharmacist\u2019s Education","volume":"82","author":"Fernandes","year":"2018","journal-title":"Am. 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