{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T08:26:41Z","timestamp":1782808001037,"version":"3.54.5"},"reference-count":150,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T00:00:00Z","timestamp":1681776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CNPq","award":["312275"],"award-info":[{"award-number":["312275"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Calendula officinalis Linn. (CO) is a popular medicinal plant from the plant kingdom\u2019s Asteraceae family that has been used for millennia. This plant contains flavonoids, triterpenoids, glycosides, saponins, carotenoids, volatile oil, amino acids, steroids, sterols, and quinines. These chemical constituents confer multifaceted biological effects such as anti-inflammatory, anti-cancer, antihelminthic, antidiabetes, wound healing, hepatoprotective, and antioxidant activities. Additionally, it is employed in cases of certain burns and gastrointestinal, gynecological, ocular, and skin conditions. In this review, we have discussed recent research from the last five years on the therapeutic applications of CO and emphasized its myriad capabilities as a traditional medicine. We have also elucidated CO\u2019s molecular mechanisms and recent clinical studies. Overall, this review intends to summarize, fill in the gaps in the existing research, and provide a wealth of possibilities for researchers working to validate traditional claims and advance the safe and effective use of CO in treating various ailments.<\/jats:p>","DOI":"10.3390\/ph16040611","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T01:39:05Z","timestamp":1681868345000},"page":"611","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":144,"title":["An Updated Review on the Multifaceted Therapeutic Potential of Calendula officinalis L."],"prefix":"10.3390","volume":"16","author":[{"given":"Kiran","family":"Shahane","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai 400019, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhuri","family":"Kshirsagar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai 400019, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4892-4889","authenticated-orcid":false,"given":"Srushti","family":"Tambe","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai 400019, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5326-4606","authenticated-orcid":false,"given":"Divya","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai 400019, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1712-1576","authenticated-orcid":false,"given":"Srutee","family":"Rout","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Food Engineering, Indian Institute of Technology, Kharagpur 721302, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Karolina Martins","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1995-136X","authenticated-orcid":false,"given":"Suraj","family":"Mali","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra 835215, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purnima","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai 400019, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem Prakash","family":"Srivastav","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Food Engineering, Indian Institute of Technology, Kharagpur 721302, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0529-3714","authenticated-orcid":false,"given":"Jorddy","family":"Cruz","sequence":"additional","affiliation":[{"name":"Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1486-4013","authenticated-orcid":false,"given":"Rafael Rodrigues","family":"Lima","sequence":"additional","affiliation":[{"name":"Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.eng.2018.11.012","article-title":"The Globalization of Traditional Medicines: Perspectives Related to the European Union Regulatory Environment","volume":"5","author":"Knoess","year":"2019","journal-title":"Engineering"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"103589","DOI":"10.1016\/j.arabjc.2021.103589","article-title":"Antiproliferative, Genotoxic Activities and Quantification of Extracts and Cucurbitacin B Obtained from Luffa operculata (L.) 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