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Research Council (BBSRC), UK","award":["RM32G0178B8"],"award-info":[{"award-number":["RM32G0178B8"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Remote Sensing"],"abstract":"<jats:p>The widespread use of mobile devices has resulted in the generation of vast amounts of spatial data. The availability of such large-scale spatial data facilitates the development of data-driven approaches to address real-life problems. This paper introduces the max coverage region (MCR) problem in road networks and provides efficient solutions. Given a set of spatial objects and a coverage radius, the MCR problem aims to identify a location from the road network, so that we can reach as many spatial objects as possible within the given coverage radius from the location. This problem is fundamental to supporting many real-world applications. Given a road network and a set of sensors, this problem can be used to find the best location for a sensor maintenance station. This problem can also be applied in medical research, such as in a protein\u2013protein interaction network, where the nodes represent proteins, the edges represent their interactions, and the weight of an edge represents confidence. We can use the MCR problem to find the set of interacting proteins with a confidence budget. We propose an efficient exact solution to solve the problem, where we reduce the MCR problem to an equivalent problem named the most overlapped interval and design an edge-level upper bound estimation method to reduce the search space. Furthermore, we propose two approximate solutions that sacrifice a little accuracy for much better efficiency. Our experimental study on real-road network datasets demonstrates the effectiveness and superiority of the proposed approaches.<\/jats:p>","DOI":"10.3390\/rs15051289","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T01:59:10Z","timestamp":1677463150000},"page":"1289","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["In Search of the Max Coverage Region in Road Networks"],"prefix":"10.3390","volume":"15","author":[{"given":"Lanting","family":"Fang","sequence":"first","affiliation":[{"name":"School of Cyber Science and Engineering, Southeast University, Nanjing 211189, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ze","family":"Kou","sequence":"additional","affiliation":[{"name":"School of Cyber Science and Engineering, Southeast University, Nanjing 211189, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhang","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Cyber Science and Engineering, Southeast University, Nanjing 211189, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4870-1493","authenticated-orcid":false,"given":"Yudong","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Computing and Mathematical Sciences, University of Leicester, Leicester LE1 7RH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George Y.","family":"Yuan","sequence":"additional","affiliation":[{"name":"Thinvent Digital Technology Co., Ltd., Nanchang 330096, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0898-1221(95)00029-X","article-title":"A unified algorithm for finding maximum and minimum object enclosing rectangles and cuboids","volume":"29","author":"Nandy","year":"1995","journal-title":"Comput. Math. Appl."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0196-6774(83)90012-3","article-title":"Finding the connected components and a maximum clique of an intersection graph of rectangles in the plane","volume":"4","author":"Imai","year":"1983","journal-title":"J. Algorithms"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Choi, D.W., Chung, C.W., and Tao, Y. (2012). A scalable algorithm for maximizing range sum in spatial databases. arXiv.","DOI":"10.14778\/2350229.2350230"},{"key":"ref_4","unstructured":"Tao, Y., Hu, X., Choi, D.W., and Chung, C.W. (2013, January 26\u201330). Approximate MaxRS in spatial databases. Proceedings of the 39th International Conference on Very Large Data Bases 2013, (VLDB 2013), Riva del Garda, Italy."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Feng, K., Cong, G., Bhowmick, S.S., Peng, W.C., and Miao, C. (July, January 26). Towards best region search for data exploration. Proceedings of the 2016 International Conference on Management of Data, San Francisco, CA, USA.","DOI":"10.1145\/2882903.2882960"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Mostafiz, M.I., Mahmud, S.F., Hussain, M.M.U., Ali, M.E., and Trajcevski, G. (2017, January 27\u201329). Class-based conditional MaxRs query in spatial data streams. Proceedings of the 29th International Conference on Scientific and Statistical Database Management, Chicago, IL, USA.","DOI":"10.1145\/3085504.3085517"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.14778\/3342263.3342277","article-title":"Finding attribute-aware similar region for data analysis","volume":"12","author":"Feng","year":"2019","journal-title":"Proc. VLDB Endow."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Kalinin, A., Cetintemel, U., and Zdonik, S. (2014, January 22\u201327). Interactive data exploration using semantic windows. Proceedings of the 2014 ACM SIGMOD International Conference on Management of Data, Snowbird, UT, USA.","DOI":"10.1145\/2588555.2593666"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.14778\/2794367.2794378","article-title":"Searchlight: Enabling integrated search and exploration over large multidimensional data","volume":"8","author":"Kalinin","year":"2015","journal-title":"Proc. VLDB Endow."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"733","DOI":"10.14778\/2732939.2732946","article-title":"Retrieving regions of interest for user exploration","volume":"7","author":"Cao","year":"2014","journal-title":"Proc. VLDB Endow."},{"key":"ref_11","unstructured":"Zhang, D., Du, Y., Xia, T., and Tao, Y. (2006, January 12\u201315). Progressive computation of the min-dist optimal-location query. Proceedings of the 32nd International Conference on Very Large Data Bases, Seoul, Republic of Korea."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Xiao, X., Yao, B., and Li, F. (2011, January 11\u201316). Optimal location queries in road network databases. Proceedings of the 2011 IEEE 27th International Conference on Data Engineering, Hannover, Germany.","DOI":"10.1109\/ICDE.2011.5767845"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Chen, Z., Liu, Y., Wong, R.C.W., Xiong, J., Mai, G., and Long, C. (2014, January 22\u201327). Efficient algorithms for optimal location queries in road networks. Proceedings of the 2014 ACM SIGMOD International Conference on Management of Data, Snowbird, UT, USA.","DOI":"10.1145\/2588555.2612172"},{"key":"ref_14","unstructured":"Du, Y., Zhang, D., and Xia, T. (2005, January 22\u201324). The optimal-location query. Proceedings of the International Symposium on Spatial and Temporal Databases, Angra dos Reis, Brazil."},{"key":"ref_15","unstructured":"Cabello, S., D\u00edaz-B\u00e1\u00f1ez, J.M., Langerman, S., Seara, C., and Ventura, I. (2006). Reverse Facility Location Problems, Citeseer."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.14778\/1687627.1687754","article-title":"Efficient method for maximizing bichromatic reverse nearest neighbor","volume":"2","author":"Wong","year":"2009","journal-title":"Proc. VLDB Endow."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"456","DOI":"10.14778\/2904121.2904122","article-title":"Maximizing bichromatic reverse spatial and textual k nearest neighbor queries","volume":"9","author":"Choudhury","year":"2016","journal-title":"Proc. VLDB Endow."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Zhou, Z., Wu, W., Li, X., Lee, M.L., and Hsu, W. (2011, January 11\u201316). Maxfirst for maxbrknn. Proceedings of the 2011 IEEE 27th International Conference on Data Engineering, Hannover, Germany.","DOI":"10.1109\/ICDE.2011.5767892"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Yan, D., Wong, R.C.W., and Ng, W. (2011, January 24\u201328). Efficient methods for finding influential locations with adaptive grids. Proceedings of the 20th ACM International Conference on Information and Knowledge Management, Glasgow, UK.","DOI":"10.1145\/2063576.2063788"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Huang, J., Wen, Z., Qi, J., Zhang, R., Chen, J., and He, Z. (2011, January 24\u201328). Top-k most influential locations selection. Proceedings of the 20th ACM International Conference on Information and Knowledge Management, Glasgow, UK.","DOI":"10.1145\/2063576.2063971"},{"key":"ref_21","unstructured":"Xia, T., Zhang, D., Kanoulas, E., and Du, Y. (September, January 30). On computing top-t most influential spatial sites. Proceedings of the 31st International Conference on Very Large Data Bases, Trondheim, Norway."},{"key":"ref_22","unstructured":"Zhan, L., Zhang, Y., Zhang, W., and Lin, X. (November, January 29). Finding top k most influential spatial facilities over uncertain objects. Proceedings of the the 21st ACM International Conference on Information and Knowledge Management, Maui, HI, USA."}],"container-title":["Remote Sensing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-4292\/15\/5\/1289\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:42:56Z","timestamp":1760121776000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-4292\/15\/5\/1289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,26]]},"references-count":22,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["rs15051289"],"URL":"https:\/\/doi.org\/10.3390\/rs15051289","relation":{},"ISSN":["2072-4292"],"issn-type":[{"value":"2072-4292","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,26]]}}}