{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:39:31Z","timestamp":1767339571520,"version":"build-2065373602"},"reference-count":171,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2010,7,7]],"date-time":"2010-07-07T00:00:00Z","timestamp":1278460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Nanostructured materials are promising compounds that offer new opportunities as sensing platforms for the detection of biomolecules. Having micrometer-scale length and nanometer-scale diameters, nanomaterials can be manipulated with current nanofabrication methods, as well as self-assembly techniques, to fabricate nanoscale bio-sensing devices. Nanostructured materials possess extraordinary physical, mechanical, electrical, thermal and multifunctional properties. Such unique properties advocate their use as biomimetic membranes to immobilize and modify biomolecules on the surface of nanoparticles. Alignment, uniform dispersion, selective growth and diameter control are general parameters which play critical roles in the successful integration of nanostructures for the fabrication of bioelectronic sensing devices. In this review, we focus on different types and aspects of nanomaterials, including their synthesis, properties, conjugation with biomolecules and their application in the construction of immunosensing devices. Some key results from each cited article are summarized by relating the concept and mechanism behind each sensor, experimental conditions and the behavior of the sensor under different conditions, etc. The variety of nanomaterial-based bioelectronic devices exhibiting novel functions proves the unique properties of nanomaterials in such sensing devices, which will surely continue to expand in the future. Such nanomaterial based devices are expected to have a major impact in clinical immunodiagnostics, environmental monitoring, security surveillance and for ensuring food safety.<\/jats:p>","DOI":"10.3390\/s100706535","type":"journal-article","created":{"date-parts":[[2010,7,7]],"date-time":"2010-07-07T11:19:07Z","timestamp":1278501547000},"page":"6535-6581","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Prospects of Nanotechnology in Clinical Immunodiagnostics"],"prefix":"10.3390","volume":"10","author":[{"given":"Anees A.","family":"Ansari","sequence":"first","affiliation":[{"name":"King Abdullah Institute for Nanotechnology, King Saud University, Riyadh-11451, P.O. Box-2455, Saudi Arabia"}]},{"given":"Mansour","family":"Alhoshan","sequence":"additional","affiliation":[{"name":"King Abdullah Institute for Nanotechnology, King Saud University, Riyadh-11451, P.O. Box-2455, Saudi Arabia"},{"name":"Department of Chemical Engineering, College of Engineering, King Saud University, Riyadh-11451, P.O. Box-2454, Saudi Arabia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4557-8821","authenticated-orcid":false,"given":"Mohamad S.","family":"Alsalhi","sequence":"additional","affiliation":[{"name":"King Abdullah Institute for Nanotechnology, King Saud University, Riyadh-11451, P.O. Box-2455, Saudi Arabia"},{"name":"Department of Physics and Astronomy, College of Science, King Saud University, Riyadh-11451, P.O. Box-2455, Saudi Arabia"}]},{"given":"Abdull S.","family":"Aldwayyan","sequence":"additional","affiliation":[{"name":"King Abdullah Institute for Nanotechnology, King Saud University, Riyadh-11451, P.O. Box-2455, Saudi Arabia"},{"name":"Department of Physics and Astronomy, College of Science, King Saud University, Riyadh-11451, P.O. Box-2455, Saudi Arabia"}]}],"member":"1968","published-online":{"date-parts":[[2010,7,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cccn.2005.03.014","article-title":"Nanotechnology in clinical laboratory diagnostics","volume":"358","author":"Jain","year":"2005","journal-title":"Clin. Chim. Acta"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1477-3155-2-3","article-title":"Applications of nanoparticles in biology and medicine","volume":"2","author":"Salata","year":"2004","journal-title":"J. Nanobiotechnol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1080\/00032710701792638","article-title":"Recent trends in the application of carbon nanotubes-polymer composite modified electrodes for biosensors: a review","volume":"41","author":"Yogeswaran","year":"2008","journal-title":"Anal. Lett"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/elan.200503449","article-title":"Nanowire-based electrochemical biosensors","volume":"18","author":"Wanekaya","year":"2006","journal-title":"Electroanalysis"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1039\/b414248a","article-title":"Nanomaterial-based electrochemical biosensors","volume":"130","author":"Wang","year":"2005","journal-title":"Analyst"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1080\/00032710701575520","article-title":"Electrochemical biosensing systems based on carbon nanotubes and carbon nanofibers","volume":"40","author":"Vamvakaki","year":"2007","journal-title":"Anal. Lett"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/elan.200503415","article-title":"Application of nanoparticles in electrochemical sensors and biosensors","volume":"18","author":"Luo","year":"2006","journal-title":"Electroanalysis"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1080\/00032710801912805","article-title":"Nanomaterials and analytical chemistry","volume":"41","author":"Valentini","year":"2008","journal-title":"Anal. Lett"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1002\/adma.200700665","article-title":"Carbon nanotubes for electronic and electrochemical detection of biomolecules","volume":"19","author":"Kim","year":"2007","journal-title":"Adv. Mater"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/elan.200403113","article-title":"Carbon-nanotube based electrochemical biosensors: a review","volume":"17","author":"Wang","year":"2005","journal-title":"Electroanalysis"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.talanta.2007.10.013","article-title":"Carbon nanotubes for electrochemical biosensing","volume":"74","author":"Rivas","year":"2007","journal-title":"Talanta"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1080\/00032710701567170","article-title":"Functional one-dimensional nanomaterials: applications in nanoscale biosensors","volume":"40","author":"Chopra","year":"2007","journal-title":"Anal Lett"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.copbio.2007.01.006","article-title":"Nanotechnological applications in medicine","volume":"18","author":"Caruthers","year":"2007","journal-title":"Curr. Opinion in Biotech"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5848","DOI":"10.1016\/j.electacta.2008.03.005","article-title":"Gold nanoparticle-based electrochemical biosensors","volume":"53","author":"Pingarron","year":"2008","journal-title":"Electrochim. Acta"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/elan.200302930","article-title":"Electroanalytical and bioelectroanalytical systems based on metal and semiconductor nanoparticles","volume":"16","author":"Katz","year":"2004","journal-title":"Electroanalysis"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.trac.2008.05.004","article-title":"Nanomaterial-based electrochemical biosensors for medical applications","volume":"27","author":"Kerman","year":"2008","journal-title":"Trends Anal. Chem"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.trac.2005.09.006","article-title":"Nanomechanical biosensors: a new sensing tool","volume":"25","author":"Carrascosa","year":"2006","journal-title":"Trends in Anal. Chem"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.tibtech.2005.02.007","article-title":"Nanobiotechnology: the promise and reality of new approaches to molecular recognition","volume":"23","author":"Fortina","year":"2005","journal-title":"Trends Biotechn"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S1369-7021(05)71287-6","article-title":"Nanofabrication with biomolecules","volume":"8","author":"Chow","year":"2005","journal-title":"Materials Today"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.nantod.2008.10.014","article-title":"Nanotechnology and nanomaterials: Promises for improved tissue regeneration","volume":"4","author":"Zhang","year":"2009","journal-title":"Nano Today"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S1369-7021(08)70056-7","article-title":"Nanostructured polymers for photonics","volume":"11","author":"Paquet","year":"2008","journal-title":"Mater. Today"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.tibtech.2007.10.005","article-title":"Nanotechnology in regenerative medicine: the materials side","volume":"26","author":"Engel","year":"2007","journal-title":"Trends Biotechnol"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1002\/smll.200700042","article-title":"The promise and perils of wide-bandgap semiconductor nanowires for sensing, electronic and photonic applications","volume":"3","author":"Pearton","year":"2007","journal-title":"Small"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1002\/adma.200500786","article-title":"Quantum dots in biological and biomedical research: recent progress and present challenges","volume":"18","author":"Klostranec","year":"2006","journal-title":"Adv. Mater"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0165-9936(04)00519-9","article-title":"Recent developments in nanomaterial optical sensors","volume":"23","author":"Shi","year":"2004","journal-title":"Trends Anal. Chem"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.3390\/s90604034","article-title":"Nanomaterials\u2014acetylcholinesterase enzyme matrices for organophosphorus pesticides electrochemical sensors: A Review","volume":"9","author":"Periasamy","year":"2009","journal-title":"Sensors"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.3390\/s8042043","article-title":"Electrochemical sensors for clinic analysis","volume":"8","author":"Wang","year":"2008","journal-title":"Sensors"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Abu-Salah, KM, Ansari, AA, and Alrokayan, SA (2010). DNA based applications in Nanobiotechnology. J Biom Biotechnol.","DOI":"10.1155\/2010\/715295"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.snb.2008.09.014","article-title":"Recent progress in the development of nano-structured conducting polymers\/nanocomposites for sensor applications","volume":"136","author":"Rajesh","year":"2009","journal-title":"Sens. Actuat. B"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1016\/j.biomaterials.2005.11.037","article-title":"Electrospinning polyaniline-contained gelatin nanofibers for tissue engineering applications","volume":"27","author":"Li","year":"2006","journal-title":"Biomaterials"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.progsolidstchem.2005.11.021","article-title":"Nanocomposites based on functionalized nanotubes in polyaniline matrix by plasma polymerization","volume":"34","author":"Nastase","year":"2006","journal-title":"Prog. Solid State Chem"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1002\/adma.200803292","article-title":"Precisely defined heterogeneous conducting polymer nanowire arrays-fabrication and chemical sensing applications","volume":"21","author":"Chen","year":"2009","journal-title":"Adv. Mater"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.progpolymsci.2004.03.002","article-title":"Polymers in sensor applications","volume":"29","author":"Adhikari","year":"2004","journal-title":"Prog. Polym. Sci"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.progpolymsci.2007.05.012","article-title":"Conducting polymers in biomedical engineering","volume":"32","author":"Guimard","year":"2007","journal-title":"Prog. Polym. Sci"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3893","DOI":"10.1021\/cr068035q","article-title":"Polymer\/silica nanocomposites: preparation, characterization, properties, and applications","volume":"108","author":"Zou","year":"2008","journal-title":"Chem. Rev"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1021\/cr068112h","article-title":"Composites of intrinsically conducting polymers as sensing nanomaterials","volume":"108","author":"Hatchett","year":"2008","journal-title":"Chem. Rev"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1021\/cr068077e","article-title":"Nanoelectrochemistry: metal nanoparticles, nanoelectrodes, and nanopores","volume":"108","author":"Murray","year":"2008","journal-title":"Chem. Rev"},{"key":"ref_38","first-page":"18","article-title":"Nanoparticles arrays on surface for electronic optical and sensor applications","volume":"1","author":"Shipway","year":"2008","journal-title":"Chempys. Chem"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/00032710701792612","article-title":"Nanostructured zinc oxide particles in chemically modified electrodes for biosensor applications","volume":"41","author":"Kumar","year":"2008","journal-title":"Anal. Lett"},{"key":"ref_40","unstructured":"Yopgeshwaran, U, Kumar, S, and Chen, S (2009). Nanostructured Materials for Electrochemical Biosensors, Nova Science Publishers."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.physe.2004.07.013","article-title":"Quantum dots in biology and medicine","volume":"25","author":"Bailey","year":"2004","journal-title":"Physica. E"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.tibtech.2004.10.012","article-title":"Semiconductor quantum dots as contrast agents for whole animal imaging","volume":"22","author":"Jiang","year":"2004","journal-title":"Trends Biot"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/nbt994","article-title":"In vivo cancer targeting and imaging with semiconductor quantum dots","volume":"22","author":"Gao","year":"2004","journal-title":"Nature Biotech"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.nantod.2008.10.009","article-title":"Applications of nanomaterials inside cells","volume":"4","author":"Gao","year":"2009","journal-title":"Nano Today"},{"key":"ref_45","first-page":"28","article-title":"Luminescent quantum dot-bioconjugates in immunoassays, FRET, biosensing, and imaging applications","volume":"9","author":"Mattoussi","year":"2004","journal-title":"J.A.L.A"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1163\/1568554053148816","article-title":"Hybrid organic\u2013inorganic nanocomposites fabricated with a novel biocompatible precursor using sol\u2013gel processing","volume":"11","author":"Shchipunov","year":"2005","journal-title":"Composite Interfaces"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1177\/0021998306067321","article-title":"Polymer-matrix nanocomposites, processing, manufacturing and application: An overview","volume":"40","author":"Hussain","year":"2006","journal-title":"J. Composite Mater"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.trac.2005.03.019","article-title":"New materials for electrochemical sensing VI: Carbon nanotubes","volume":"24","author":"Merkoci","year":"2005","journal-title":"Trend. Anal. Chem"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1021\/cm702141e","article-title":"Inorganic and hybrid nanofibrous materials templated with organogelators","volume":"20","author":"Llusar","year":"2008","journal-title":"Chem. Mater"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.pmatsci.2006.08.001","article-title":"One dimensional nanostructured materials","volume":"52","author":"Kuchibhatla","year":"2007","journal-title":"Prog. Mater. Science"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0025-5408(96)00031-1","article-title":"A new conducting nanocomposites-ppy-zirconium oxide","volume":"31","author":"Bhattacharya","year":"1996","journal-title":"Mater. Res. Bull"},{"key":"ref_52","unstructured":"Aiden, EK, and Gabriel, TDL (2010). Nanoparticles: Properties, Classification, Characterization, and Fabrication, Nova Science Publishers."},{"key":"ref_53","unstructured":"Serra, PA (2010). Biosensors, INTECH."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"963","DOI":"10.3390\/s100100963","article-title":"Nanomaterials as analytical tools for genosensors","volume":"10","author":"Alrokyan","year":"2010","journal-title":"Sensors"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1038\/1841648b0","article-title":"Assay of plasma insulin in human subjects by immunological methods","volume":"184","author":"Yalow","year":"1959","journal-title":"Nature"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1749-6632.1962.tb13623.x","article-title":"Electrode systems for continuous monitoring in cardiovascular surgery","volume":"102","author":"Clark","year":"1962","journal-title":"Ann. N. Y. Acad Sci"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0956-5663(97)00031-6","article-title":"Immunosensors: electrochemical sensing and other engineering approaches","volume":"13","author":"Ghindilis","year":"1998","journal-title":"Biosens. Bioelectron"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/j.bios.2008.01.035","article-title":"Immunosensors for detection of pesticide residues","volume":"23","author":"Jiang","year":"2008","journal-title":"Biosens. Bioelectron"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.aca.2007.10.046","article-title":"A review on novel developments and applications of immunosensors in food analysis","volume":"605","author":"Ricci","year":"2007","journal-title":"Anal. Chim. Acta"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1389-1723(04)70195-4","article-title":"Impedomatric biosensors","volume":"97","author":"Guan","year":"2004","journal-title":"J. Biosci. Bioeng"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/elan.200390114","article-title":"Probing biomolecular interactions at conductive and semiconductive surfaces by impedance spectroscopy: routes to impedomatric immunosensors. DNA-sensors, and enzyme biosensors","volume":"15","author":"Katz","year":"2003","journal-title":"Electroanalysis"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1039\/B517148B","article-title":"An impedance array biosensor for detection of multiple antibody\u2013antigen Interactions","volume":"131","author":"Yu","year":"2006","journal-title":"Analyst"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.aca.2007.08.003","article-title":"Recent developments in potentiometric biosensors for biomedical analysis","volume":"599","author":"Koncki","year":"2007","journal-title":"Anal. Chim. Acta"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0956-5663(03)00020-4","article-title":"A conductometric biosensor for biosecurity","volume":"18","author":"Tahir","year":"2003","journal-title":"Biosens. Bioelectron"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.bej.2009.03.002","article-title":"Enhanced conductometric immunoassay for hepatitis B surface antigen using double-codified nanogold particles as labels","volume":"45","author":"Liu","year":"2009","journal-title":"Biochem. Engin. J"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1039\/B512546D","article-title":"Lab-on-a-chip with integrated optical transducers","volume":"6","author":"Balslev","year":"2006","journal-title":"Lab Chip"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.aca.2008.05.022","article-title":"Sensitive optical biosensors for unlabeled targets: A review","volume":"620","author":"Fan","year":"2008","journal-title":"Anal. Chim. Acta"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1016\/j.bios.2004.11.003","article-title":"Nanoparticle labels in immunosensing using optical detection methods","volume":"20","author":"Seydack","year":"2005","journal-title":"Biosens. Bioelectron"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3390\/s7060797","article-title":"Recent development in optical fiber biosensors","volume":"7","author":"Bosch","year":"2007","journal-title":"Sensors"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.talanta.2006.09.029","article-title":"Optical sensors and biosensors based on sol\u2013gel films","volume":"72","author":"Jeronimo","year":"2007","journal-title":"Talanta"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.bios.2003.12.002","article-title":"Development of a novel optical bionanosensor","volume":"19","author":"Worsfold","year":"2004","journal-title":"Biosens. Bioelectron"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.semcdb.2009.01.013","article-title":"Optical biosensors for probing at the cellular level: A review of recent progress and future prospects","volume":"20","author":"Garcia","year":"2009","journal-title":"Seminars Cell Develop. Biol"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.1002\/anie.200806328","article-title":"Dual-function probe to detect protease activity for fluorescence measurement and 19F MRI","volume":"48","author":"Mizukami","year":"2009","journal-title":"Angew. Chem. Int. Ed"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.talanta.2005.06.039","article-title":"Towards advanced chemical and biological nanosensors-An overview","volume":"67","author":"Yonzon","year":"2005","journal-title":"Talanta"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bios.2007.07.001","article-title":"Towards integrated and sensitive surface plasmon resonance biosensors: A review of recent progress","volume":"23","author":"Hoa","year":"2007","journal-title":"Biosens. Bioelectron"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.talanta.2005.09.004","article-title":"CdSe quantum dots as luminescent probes for spironolactone determination","volume":"69","author":"Liang","year":"2006","journal-title":"Talanta"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.talanta.2007.05.011","article-title":"Use of CdSe\/ZnS core-shell quantum dots as energy transfer donors in sensing glucose","volume":"73","author":"Duong","year":"2007","journal-title":"Talanta"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.talanta.2005.04.036","article-title":"Fluorescence resonance energy transfer in doubly-quantum dot labeled IgG system","volume":"67","author":"Ma","year":"2005","journal-title":"Talanta"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"8374","DOI":"10.1002\/chem.200701307","article-title":"A new aptameric biosensor for cocaine based on surface-enhanced Raman scattering spectroscopy","volume":"14","author":"Chen","year":"2008","journal-title":"Chem. Eur. J"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0039-9140(97)00392-5","article-title":"Piezoelectric quartz crystal biosensors","volume":"46","author":"Bunde","year":"1998","journal-title":"Talanta"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1063\/1.1784039","article-title":"Metal piezoelectric semiconductor field effect transistors for piezoelectric strain sensors","volume":"85","author":"Wu","year":"2004","journal-title":"Appl. Phys. Lett"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1039\/b802120a","article-title":"Novel superparamagnetic core-shell molecular imprinting microspheres towards high selective sensing","volume":"133","author":"Jin","year":"2008","journal-title":"Analyst"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.bios.2006.06.030","article-title":"Quartz crystal microbalance immunosensors for environmental monitoring","volume":"22","author":"Kurosawa","year":"2006","journal-title":"Biosens. Bioelectron"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0009-8981(01)00629-5","article-title":"Immunosensors-principles and applications to clinical chemistry","volume":"314","author":"Luppa","year":"2001","journal-title":"Clinica Chim. Acta"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/j.biomaterials.2009.01.002","article-title":"Bienzyme functionalized three-layer composite magnetic nanoparticles for electrochemical immunosensors","volume":"30","author":"Zhuo","year":"2009","journal-title":"Biomaterials"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.aca.2004.11.064","article-title":"A novel amperomatric immunosensor based on three-dimensional sol\u2013gel network and nanoparticle self-assemble technique","volume":"534","author":"Liang","year":"2005","journal-title":"Anal. Chim. Acta"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.elecom.2005.02.001","article-title":"A reagentless amperomatric immunosensor based on gold nanoparticles\/thionine\/Nafion-membrane-modified gold electrode for determination of \u03b1-1-fetoprotein","volume":"7","author":"Zhuo","year":"2005","journal-title":"Electrochem. Commun"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.aca.2008.03.054","article-title":"A reagentless amperomatric immunosensor for \u03b1-1-fetoprotein based on gold nanowires and ZnO nanorods modified electrode","volume":"615","author":"Lu","year":"2008","journal-title":"Anal. Chim. Acta"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.bios.2008.07.075","article-title":"A novel reagentless amperomatric immunosensor based on gold nanoparticles\/TMB\/Nafion-modified electrode","volume":"24","author":"Wu","year":"2009","journal-title":"Biosens. Bioelectron"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.aca.2005.12.061","article-title":"A microelectronic technology based amperomatric immunosensor for a-fetoprotein using mixed self-assembled monolayers and gold nanoparticles","volume":"561","author":"Xu","year":"2006","journal-title":"Anal. Chim. Acta"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.aca.2007.08.052","article-title":"A novel amperomatric immunosensor based on layer-by-layer assembly of gold nanoparticles\u2013multi-walled carbon nanotubes-thionine multilayer films on polyelectrolyte surface","volume":"603","author":"Ou","year":"2007","journal-title":"Anal. Chim. Acta"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1016\/j.electacta.2006.10.031","article-title":"Development of an amperomatric immunosensor based on TiO2 nanoparticles and gold nanoparticles","volume":"52","author":"Shi","year":"2007","journal-title":"Electrochim. Acta"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jelechem.2007.02.027","article-title":"Amplification of antigen\u2013antibody interactions via back-filling of HRP on the layer-by-layer self-assembling of thionine and gold nanoparticles films on Titania nanoparticles\/gold nanoparticles-coated Au electrode","volume":"604","author":"Shi","year":"2007","journal-title":"J. Electroanal. Chem"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jelechem.2009.01.016","article-title":"Enhancement of carcinoembryonic antibody immobilization on gold electrode modified by gold nanoparticles and SiO2\/Thionine nanocomposite","volume":"628","author":"Zhuo","year":"2009","journal-title":"J. Electroanal. Chem"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.2116\/analsci.23.1059","article-title":"Electrochemical immunosensor for carcinoembryonic antigen based on antigen immobilization in gold nanoparticles modified chitosan membrane","volume":"23","author":"Lin","year":"2007","journal-title":"Anal. Science"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.aca.2005.05.058","article-title":"An amperomatric immunosensor based on immobilization of hepatitis B surface antibody on gold electrode modified gold nanoparticles and horseradish peroxidase","volume":"548","author":"Zhuo","year":"2005","journal-title":"Anal. Chim. Acta"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.elecom.2007.01.036","article-title":"A disposable amperomatric enzyme immunosensor for rapid detection of Vibrio parahaemolyticus in food based on agarose\/Nano-Au membrane and screen-printed electrode","volume":"9","author":"Zhao","year":"2007","journal-title":"Electrochem. Commun"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.jprot.2007.11.007","article-title":"Biomolecules\/gold nanowires-doped sol\u2013gel film for label-free electrochemical immunoassay of testosterone","volume":"70","author":"Liang","year":"2007","journal-title":"J. Biochem. Biophys. Methods"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"8262","DOI":"10.3390\/s8128262","article-title":"Electrochemical immunosensor based on polythionine\/gold nanoparticles for the determination of aflatoxin B1","volume":"8","author":"Owino","year":"2008","journal-title":"Sensors"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.elecom.2004.12.004","article-title":"Study on electrochemical behavior of a diphtheria immunosensor based on silica\/silver\/gold nanoparticles and polyvinyl butyral as matrices","volume":"7","author":"Tang","year":"2005","journal-title":"Electrochem. Commun"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0039-9140(03)00368-0","article-title":"A label-free electrochemical immunosensor based on gold nanoparticles for detection of paraoxon","volume":"61","author":"Hu","year":"2003","journal-title":"Talanta"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.bios.2004.11.024","article-title":"New amperomatric and potentiometric immunosensors based on gold nanoparticles\/tris (2,2-bipyridyl)cobalt(III) multilayer films for hepatitis B surface antigen determinations","volume":"21","author":"Tang","year":"2005","journal-title":"Biosens. & Bioelectron"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1166\/jnn.2005.178","article-title":"Renewable electrochemical magnetic immunosensor based on gold nanoparticle labels","volume":"5","author":"Liu","year":"2005","journal-title":"J. Nanosci. Nanotechnol"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00449-007-0145-9","article-title":"Magneto-controlled bioelectronics for the antigen\u2013antibody interaction based on magnetic-core\/gold-shell nanoparticles functionalized biomimetic interface","volume":"31","author":"Tang","year":"2008","journal-title":"Bioprocess Biosyst. Eng"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s00216-006-0976-2","article-title":"A novel amperomatric immunosensor based on Fe3O4 magnetic nanoparticles\/chitosan composite film for determination of ferritin","volume":"387","author":"Wang","year":"2007","journal-title":"Anal Bioanal Chem"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.elecom.2008.07.007","article-title":"Chitosan\u2013iron oxide nanobiocomposite based immunosensor for ochratoxin-A","volume":"10","author":"Kaushik","year":"2008","journal-title":"Electrochem. Commun"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.snb.2005.04.002","article-title":"Core\u2013shell magnetic nanoparticles applied for immobilization of antibody on carbon paste electrode and amperomatric immunosensing","volume":"113","author":"Liu","year":"2006","journal-title":"Sensor. Actuat. B"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0003-2670(03)00089-8","article-title":"Piezoelectric immunosensor based on magnetic nanoparticles with simple immobilization procedures","volume":"481","author":"Li","year":"2003","journal-title":"Anal Chim Acta"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.bios.2007.11.003","article-title":"Integrated microfluidic systems with an immunosensor modified with carbon nanotubes for detection of prostate specific antigen (PSA)in human serum samples","volume":"23","author":"Panini","year":"2008","journal-title":"Biosens. Bioelectron"},{"key":"ref_110","first-page":"70","article-title":"Protein immunosensor using single-wall carbon nanotube forests with electrochemical detection of enzyme labels","volume":"1","author":"Yu","year":"2005","journal-title":"Mol. Bio Syst"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1021\/ac051435d","article-title":"Electrochemical immunosensor for cholera toxin using liposomes and poly (3,4-ethylenedioxythiophene)-coated carbon nanotubes","volume":"78","author":"Viswanathan","year":"2006","journal-title":"Anal. Chem"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.bios.2007.04.021","article-title":"Carbon nanotube\/polysulfone screen printed electrochemical immunosensor","volume":"23","author":"Sanchez","year":"2007","journal-title":"Biosens. Bioelectron"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1039\/b412805b","article-title":"Mediated amperomatric immunosensing using single walled carbon nanotube forests","volume":"129","author":"Kim","year":"2004","journal-title":"Analyst"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"11199","DOI":"10.1021\/ja062117e","article-title":"Carbon nanotube amplification strategies for highly sensitive immunodetection of cancer biomarkers","volume":"128","author":"Yu","year":"2006","journal-title":"J. Am. Chem. Soc"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"7126","DOI":"10.1021\/ac049107l","article-title":"Electrochemical coding for multiplexed immunoassays of proteins","volume":"76","author":"Liu","year":"2004","journal-title":"Anal. Chem"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"8494","DOI":"10.1021\/ac070923d","article-title":"Versatile immunosensor using CdTe quantum dots as electrochemical and fluorescent labels","volume":"79","author":"Cui","year":"2007","journal-title":"Anal. Chem"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"7644","DOI":"10.1021\/ac070691i","article-title":"Disposable electrochemical immunosensor diagnosis device based on nanoparticle probe and immunochromatographic strip","volume":"79","author":"Liu","year":"2007","journal-title":"Anal. Chem"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"9951","DOI":"10.1002\/chem.200800412","article-title":"Nanoparticle-based electrochemical immunosensor for the detection of phosphorylated acetylcholinesterase: An exposure biomarker of organophosphate pesticides and nerve agents","volume":"14","author":"Liu","year":"2008","journal-title":"Chem. Eur. J"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.talanta.2008.12.017","article-title":"Porous redox-active Cu2O\u2013SiO2 nanostructured film: Preparation, characterization and application for a label-free amperomatric ferritin immunosensor","volume":"78","author":"Yang","year":"2009","journal-title":"Talanta"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1016\/j.bios.2010.01.029","article-title":"Gold nanoparticles based sandwich electrochemical immunosensor","volume":"25","author":"Ahirwal","year":"2010","journal-title":"Biosens. Bioelectron"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.aca.2009.11.023","article-title":"A disposable electrochemical immunosensor for carcinoembryonic antigen based on nano-Au\/multi-walled carbon nanotubes\u2013chitosans nanocomposite film modified glassy carbon electrode","volume":"659","author":"Huang","year":"2010","journal-title":"Anal. Chim. Acta"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/j.electacta.2009.10.067","article-title":"Multilayer structured amperometric immunosensor based on gold nanoparticles and Prussian blue nanoparticles\/nanocomposite functionalized interface","volume":"55","author":"Song","year":"2010","journal-title":"Electrochim. Acta"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.snb.2010.01.061","article-title":"Dual amplification strategy for the fabrication of highly sensitive amperometric immunosensor based on nanocomposite functionalized interface","volume":"145","author":"Song","year":"2010","journal-title":"Sensors and Actuat. B"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Cui, R, and Zhu, JJ (2010). Fabrication of a novel electrochemical immunosensor based on the gold nanoparticles\/colloidal carbon nanosphere hybrid material. Electrochimica Acta.","DOI":"10.1016\/j.electacta.2010.03.022"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jelechem.2010.03.014","article-title":"A novel label-free electrochemical immunosensor for carcinoembryonic antigen detection based on the [Ag\u2013Ag2O]\/SiO2 nanocomposite material as a redox probe","volume":"643","author":"Yuan","year":"2010","journal-title":"J. Electroanal. Chem"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1016\/j.biomaterials.2010.01.033","article-title":"Multifunctional mesoporous silica nanoparticles as labels for the preparation of ultrasensitive electrochemical immunosensors","volume":"31","author":"Yang","year":"2010","journal-title":"Biomaterials"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.bios.2009.12.010","article-title":"Novel polymeric bionanocomposites with catalytic Pt nanoparticles label immobilized for high performance amperometric immunoassay","volume":"25","author":"Fu","year":"2010","journal-title":"Biosens. Bioelectron"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jcis.2010.01.033","article-title":"Amperometric immunosensor for the determination of \u03b1-1-fetoprotein based on multiwalled carbon nanotube\u2013silver nanoparticle composite","volume":"345","author":"Che","year":"2010","journal-title":"J. Colloid and Inter. Sci"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.bios.2009.12.024","article-title":"An amperometric chloramphenicol immunosensor based on cadmium sulfide nanoparticles modified-dendrimer bonded conducting polymer","volume":"25","author":"Kim","year":"2010","journal-title":"Bios. Bioelectronic"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"055105","DOI":"10.1088\/0957-4484\/20\/5\/055105","article-title":"A nanostructured cerium oxide film-based immunosensor for mycotoxin detection","volume":"20","author":"Kaushik","year":"2009","journal-title":"Nanotechnology"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1088\/1742-6596\/61\/1\/112","article-title":"Nano-particle enhanced impedomatric biosensor for detection of foodborne pathogens","volume":"61","author":"Kim","year":"2007","journal-title":"J. Phys. Conf. Series"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.talanta.2006.05.081","article-title":"A sensitive impedance immunosensor based on functionalized gold nanoparticle\u2013protein composite films for probing apolipoprotein A-I","volume":"71","author":"Zhang","year":"2007","journal-title":"Talanta"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1021\/ac7021376","article-title":"Electrochemical impedance immunosensor based on three-dimensionally ordered macroporous gold film","volume":"80","author":"Chen","year":"2008","journal-title":"Anal. Chem"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.elecom.2008.01.013","article-title":"Nanocrystalline bioactive TiO2\u2013chitosan impedomatric immunosensor for ochratoxin-A","volume":"10","author":"Khan","year":"2008","journal-title":"Electrochem. Commun"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bioelechem.2009.06.014","article-title":"Nanostructured zinc oxide platform for mycotoxin detection","volume":"77","author":"Ansari","year":"2010","journal-title":"Bioelectrochemistry"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.bios.2009.10.036","article-title":"An electrochemical impedimetric immunosensor for label-free detection of Campylobacter jejuni in diarrhea patients\u2019 stool based on O-carboxymethylchitosan surface modified Fe3O4 nanoparticles","volume":"25","author":"Huang","year":"2010","journal-title":"Biosens. Bioelectron"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1021\/ac070932m","article-title":"Potentiometric immunoassay with quantum dot labels","volume":"79","author":"Thurer","year":"2007","journal-title":"Anal. Chem"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1021\/ac971298n","article-title":"Thick-film electrochemical immunosensor based on stripping potentiometric detection of a metal ion label","volume":"70","author":"Wang","year":"1998","journal-title":"Anal. Chem"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.elecom.2008.04.009","article-title":"A conductometric immunosensor based on functionalized magnetite nanoparticles for E. coli detection","volume":"10","author":"Hnaiein","year":"2008","journal-title":"Electrochem. Commun"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"4770","DOI":"10.1002\/adma.200801302","article-title":"Electrospun nanofibrous membranes: A novel solid substrate for microfluidic immunoassays for HIV","volume":"20","author":"Yang","year":"2008","journal-title":"Adv. Mater"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.talanta.2006.07.027","article-title":"Quantum dot-based immunosensor for the detection of prostate-specific antigen using fluorescence microscopy","volume":"71","author":"Kerman","year":"2007","journal-title":"Talanta"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.talanta.2008.05.002","article-title":"The application of CdTe@SiO2 particles in immunoassay","volume":"76","author":"Jin","year":"2008","journal-title":"Talanta"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"8796","DOI":"10.1021\/ac0709605","article-title":"Detection of pathogens using luminescent CdSe\/ZnS dendron nanocrystals and a porous membrane immunofilter","volume":"79","author":"Liu","year":"2007","journal-title":"Anal. Chem"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1477-3155-6-10","article-title":"Capillary electrophoresis for the characterization of quantum dots after non-selective or selective bioconjugation with antibodies for immunoassay","volume":"6","author":"Pereira","year":"2008","journal-title":"J. Nanobiotechno"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1039\/b718730k","article-title":"Antibody\u2013gold quantum dot\u2013PAMAM dendrimer complex as an immunoglobulin immunoassay","volume":"133","author":"Triulzi","year":"2008","journal-title":"Analyst"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1021\/ac061507g","article-title":"Development of zeptomole and attomolar detection sensitivity of biotin-peptide using a dot-blot gold nanoparticle immunoassay","volume":"79","author":"Hou","year":"2007","journal-title":"Anal. Chem"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.talanta.2006.07.036","article-title":"A novel immunoassay strategy based on combination of chitosan and a gold nanoparticle label","volume":"71","author":"Zhang","year":"2007","journal-title":"Talanta"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1021\/ac062341m","article-title":"Characterization and optimization of gold nanoparticle-based silver-enhanced immunoassays","volume":"79","author":"Gupta","year":"2007","journal-title":"Anal. Chem"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1021\/ac702555r","article-title":"Gold nanohole array substrates as immunobiosensors","volume":"80","author":"Sharpe","year":"2008","journal-title":"Anal Chem"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Tian, D, Duan, C, Wang, W, and Cui, H (2010). Ultrasensitive electrochemiluminescence immunosensor based on luminal functionalized gold nanoparticle labeling. Biosens Bioelectron.","DOI":"10.1016\/j.bios.2010.03.014"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.elecom.2009.10.027","article-title":"Electrochemiluminescence immunosensor based on nanocomposite film of CdS quantum dots-carbon nanotubes combined with gold nanoparticles-chitosan","volume":"12","author":"Jie","year":"2010","journal-title":"Electrochem. Commun"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1002\/adma.200702188","article-title":"Confinement-induced enhancement of antigen\u2013antibody interactions within binary nanopatterns to achieve higher efficiency of on-chip immunosensors","volume":"20","author":"Krishnamoorthy","year":"2008","journal-title":"Adv. Mater"},{"key":"ref_153","first-page":"331","article-title":"A localized surface plasmon resonance based immunosensor for the detection of casein in milk","volume":"8","author":"Hiepa","year":"2007","journal-title":"SciTechnol Adv Mater"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1748-0132(08)70042-2","article-title":"Novel nanostructures for SERS biosensing","volume":"3","author":"Tripp","year":"2008","journal-title":"Nanotoday"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1002\/adma.200701984","article-title":"SERS as a Foundation for Nanoscale, optically detected biological labels","volume":"19","author":"Doering","year":"2007","journal-title":"Adv Mater"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1126\/science.289.5485.1757","article-title":"Scanometric DNA array detection with nanoparticle probes","volume":"289","author":"Taton","year":"2000","journal-title":"Science"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"6967","DOI":"10.1021\/ac0607663","article-title":"Nanoparticle probes with surface enhanced Raman spectroscopic tags for cellular cancer targeting","volume":"78","author":"Kim","year":"2006","journal-title":"Anal. Chem"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1039\/a827241z","article-title":"Surface-enhanced Raman scattering","volume":"27","author":"Campion","year":"1998","journal-title":"Chem. Soc. Rev"},{"key":"ref_159","unstructured":"Rossiter, BW, and Baetzold, RC (1992). Physical Methods of Chemistry, Wiley."},{"key":"ref_160","unstructured":"Abruna, HD (1991). Electrochemical interfacesmodern techniques for in-situ characterization, VCH Verlag Chemie."},{"key":"ref_161","unstructured":"Chang, RK, and Furtak, TE (1982). Plenum Press."},{"key":"ref_162","unstructured":"Laserna, JJ (1996). modern techniques in Raman Spectroscopy, Wiley."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/jrs.1362","article-title":"Surface-enhanced Raman spectroscopy: a brief retrospective","volume":"36","author":"Moskovits","year":"2005","journal-title":"J. Raman Spectros"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/(SICI)1097-4555(199612)27:12<879::AID-JRS45>3.0.CO;2-6","article-title":"Chemical effect of SERS with near-infrared excitation","volume":"27","author":"Liang","year":"1996","journal-title":"J. Raman Spectros"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1021\/ac801431m","article-title":"Electrostatic interaction based approach to thrombin detection by surface-enhanced Raman spectroscopy","volume":"81","author":"Hu","year":"2009","journal-title":"Anal. Chem"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1021\/ac802037x","article-title":"Multiplex immunoassay using fluorescent-surface enhanced Raman spectroscopic dots for the detection of bronchioalveolar stem cells in murine lung","volume":"81","author":"Woo","year":"2009","journal-title":"Anal. Chem"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0003-2670(03)00089-8","article-title":"Piezoelectric immunosensor based on magnetic nanoparticles with simple immobilization procedures","volume":"481","author":"Li","year":"2003","journal-title":"Anal. Chim. Acta"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1039\/b606294f","article-title":"A bio-barcode assay for on-chip attomolar-sensitivity protein detection","volume":"6","author":"Goluch","year":"2006","journal-title":"Lab Chip"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.bios.2006.02.020","article-title":"Morphological and binding properties of interleukin-6 on thin ZnO films grown on (100) silicon substrates for biosensor applications","volume":"22","author":"Krishnamoorthy","year":"2006","journal-title":"Biosens. Bioelectron"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1021\/ac060830g","article-title":"Label-free protein biosensor based on aptamer-modified carbon nanotube field-effect transistors","volume":"79","author":"Maehashi","year":"2007","journal-title":"Anal. Chem"},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Shen, G, and Lu, J (2010). Piezoelectric immunosensor based on gold nanoparticles capped with mixed self-assembled monolayer for detection of carcinoembryonic antigen. Thin Solid Films.","DOI":"10.1016\/j.tsf.2010.03.077"}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/10\/7\/6535\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T22:02:52Z","timestamp":1760220172000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/10\/7\/6535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,7]]},"references-count":171,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2010,7]]}},"alternative-id":["s100706535"],"URL":"https:\/\/doi.org\/10.3390\/s100706535","relation":{},"ISSN":["1424-8220"],"issn-type":[{"type":"electronic","value":"1424-8220"}],"subject":[],"published":{"date-parts":[[2010,7,7]]}}}