{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T01:05:04Z","timestamp":1770771904631,"version":"3.50.0"},"reference-count":32,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Proof-of-concept studies that display the potential of using a glucose-sensitive hydrogel as a continuous glucose sensor are presented. The swelling ratio, porosity, and diffusivity of the hydrogel increased with glucose concentration. In glucose solutions of 50, 100, 200, and 300 mg\/dL, the hydrogel swelling ratios were 4.9, 12.3, 15.9, and 21.7, respectively, and the swelling was reversible. The impedance across the hydrogel depended solely on the thickness and had an average increase of 47 W\/mm. The hydrogels exposed to a hyperglycemic solution were more porous than the hydrogels exposed to a normal glycemic solution. The diffusivity of 390 Da MW fluorescein isothiocyanate in hydrogels exposed to normal and hyperglycemic solutions was examined using fluorescence recovery after photobleaching and was found to be 9.3 \u00d7 10\u221214 and 41.4 \u00d7 10\u221214 m2\/s, respectively, compared to 6.2 \u00d7 10\u221210 m2\/s in glucose solution. There was no significant difference between the permeability of hydrogels in normal and hyperglycemic glucose solutions with averages being 5.26 \u00d7 10\u221217 m2 and 5.80 \u00d7 10\u221217 m2, respectively, which resembles 2\u20134% agarose gels. A prototype design is presented for continuous intravascular glucose monitoring by attaching a glucose sensor to an FDA-approved stent.<\/jats:p>","DOI":"10.3390\/s110100409","type":"journal-article","created":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T08:36:38Z","timestamp":1293784598000},"page":"409-424","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Toward a Continuous Intravascular Glucose Monitoring System"],"prefix":"10.3390","volume":"11","author":[{"given":"Brooke","family":"Beier","sequence":"first","affiliation":[{"name":"The Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA"}]},{"given":"Katherine","family":"Musick","sequence":"additional","affiliation":[{"name":"The Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA"}]},{"given":"Akira","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 Japan"}]},{"given":"Alyssa","family":"Panitch","sequence":"additional","affiliation":[{"name":"The Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA"}]},{"given":"Eric","family":"Nauman","sequence":"additional","affiliation":[{"name":"The Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA"},{"name":"Department of Basic Medical Sciences, Purdue University, West Lafayette, IN 47907, USA"},{"name":"School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA"}]},{"given":"Pedro","family":"Irazoqui","sequence":"additional","affiliation":[{"name":"The Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA"}]}],"member":"1968","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"ref_1","unstructured":"(2008). 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