{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T13:56:00Z","timestamp":1765806960968,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2011,1,20]],"date-time":"2011-01-20T00:00:00Z","timestamp":1295481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>A respiratory monitoring system based on a quartz crystal microbalance (QCM) sensor with a functional film was designed and investigated. Porphyrins 5,10,15,20-tetrakis-(4-sulfophenyl)-21H,23H-porphine (TSPP) and 5,10,15,20-tetrakis-(4-sulfophenyl)-21H, 23H-porphine manganese (III) chloride (MnTSPP) used as sensitive elements were assembled with a poly(diallyldimethyl ammonium chloride) (PDDA). Films were deposited on the QCM resonators using layer-by-layer method in order to develop the sensor. The developed system, in which the sensor response reflects lung movements, was able to track human respiration providing respiratory rate (RR) and respiratory pattern (RP). The sensor system was tested on healthy volunteers to compare RPs and calculate RRs. The operation principle of the proposed system is based on the fast adsorption\/desorption behavior of water originated from human breath into the sensor films deposited on the QCM electrode.<\/jats:p>","DOI":"10.3390\/s110101177","type":"journal-article","created":{"date-parts":[[2011,1,20]],"date-time":"2011-01-20T11:51:03Z","timestamp":1295524263000},"page":"1177-1191","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Respiratory Monitoring by Porphyrin Modified Quartz Crystal Microbalance Sensors"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0846-2416","authenticated-orcid":false,"given":"Roman","family":"Selyanchyn","sequence":"first","affiliation":[{"name":"Graduate School of Environmental Engineering, The University of Kitakyushu, 1-1 Hibikino, Wakamatsu, Kitakyushu 808-0135, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serhiy","family":"Korposh","sequence":"additional","affiliation":[{"name":"Graduate School of Environmental Engineering, The University of Kitakyushu, 1-1 Hibikino, Wakamatsu, Kitakyushu 808-0135, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunichi","family":"Wakamatsu","sequence":"additional","affiliation":[{"name":"Chitose Technical Center, Nihon Dempa Kogyo Co. Ltd., 1-3-1, Minami-Chitose, Hokkaido 066-0009, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Graduate School of Environmental Engineering, The University of Kitakyushu, 1-1 Hibikino, Wakamatsu, Kitakyushu 808-0135, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2011,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/BF02348078","article-title":"Critical review of non-invasive respiratory monitoring in medical care","volume":"41","author":"Folke","year":"2003","journal-title":"Med. Biol. Eng. Comput"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/00000542-197303000-00021","article-title":"A new disposable spirometer","volume":"383","author":"Lecky","year":"1973","journal-title":"Anesthesiol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1152\/jappl.1964.19.1.166","article-title":"Volumetric dynamics of respiration as measured by electrical impedance plethysmography","volume":"19","author":"Allison","year":"1964","journal-title":"J. Appl. Physiol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1159\/000212117","article-title":"Respiratory monitoring by inductive plethysmography in unrestrained subjects using position sensor-adjusted calibration","volume":"79","author":"Fritsch","year":"2010","journal-title":"Respiration"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0140-6736(69)90378-X","article-title":"An apnoea-alarm mattress","volume":"294","author":"Lewin","year":"1969","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/BF02474710","article-title":"Monitoring of breathing with a segmental air-filled mattress","volume":"9","author":"Gundersen","year":"1971","journal-title":"Med. Biol. Eng. Comput"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1542\/peds.71.1.53","article-title":"Apnea monitoring by acoustic detection of airflow","volume":"71","author":"Werthammer","year":"1983","journal-title":"Pediatrics"},{"key":"ref_8","first-page":"269","article-title":"Capnography","volume":"46","author":"Butani","year":"2002","journal-title":"Indian J. Anaesth"},{"key":"ref_9","first-page":"57","article-title":"Pulse oximetry and capnography in intensive and transitional care units","volume":"156","author":"Bongard","year":"1992","journal-title":"West. J. Med"},{"doi-asserted-by":"crossref","unstructured":"Liang, Y., Mazzolini, A.P., and Stoddart, P.R. (2006, January July). Fiber Bragg Grating for Respiratory Monitoring. Melbourne, Austrilia.","key":"ref_10","DOI":"10.1109\/ACOFT.2006.4519217"},{"doi-asserted-by":"crossref","unstructured":"Higashikaturagi, K., Nakahata, Y., Matsunami, I., and Kajiwara, A. (2008, January September). Non-Invasive Respiration Monitoring Sensor Using UWB-IR. Hannover, Germany.","key":"ref_11","DOI":"10.1109\/ICUWB.2008.4653294"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1378\/chest.122.2.684","article-title":"Tidal volume and respiratory timing derived from a portable ventilation monitor","volume":"122","author":"McCool","year":"2002","journal-title":"Chest"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1378\/chest.116.5.1416","article-title":"Partitioning of lung and chest-wall mechanics before and after lung-volume-reduction surgery","volume":"116","author":"Jubran","year":"1999","journal-title":"Chest"},{"unstructured":"Walker, H.K., Hall, W.D., and Hurst, J.W. (1990). Clinical Methods: The History, Physical and Laboratory Examinations, Butterworth Publishers.","key":"ref_14"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0956-5663(99)00040-8","article-title":"Commercial quartz crystal microbalances\u2014Theory and applications","volume":"14","author":"Guilbault","year":"1999","journal-title":"Biosens. Bioel"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.snb.2008.09.055","article-title":"Investigation of quartz microbalance and ChemFET transduction of molecular recognition events in a metalloporphyrin film","volume":"135","author":"Buchholt","year":"2009","journal-title":"Sens. Actuat. B"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/BF01337937","article-title":"Verwendung von schwingquarzen zur w\u00e4gung d\u00fcnner schichten und microw\u00e4gung","volume":"155","author":"Sauerbrey","year":"1959","journal-title":"Zeit. Physik"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.snb.2004.04.001","article-title":"A highly sensitive QCM sensor coated with Ag+-ZSM-5 film for medical diagnosis","volume":"101","author":"Huang","year":"2004","journal-title":"Sens. Actuat. B"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0003-2670(96)00017-7","article-title":"The application of metalloporphyrins as coating material for quartz microbalance-based chemical sensors","volume":"325","author":"Brunink","year":"1996","journal-title":"Anal. Chim. Acta"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00604-008-0949-6","article-title":"Chemical images by porphyrin arrays of sensors","volume":"63","author":"Paolesse","year":"2008","journal-title":"Microchim. Acta"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1023\/A:1009405412172","article-title":"Spectroscopic characterization of porphyrin-doped sol-gel-derived matrices","volume":"10","author":"Hungerford","year":"2000","journal-title":"J. Fluoresc"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"125","DOI":"10.4024\/30603.jbpc.06.03","article-title":"Nano-assembled thin film gas sensors. I. Ammonia detection by a porphyrin-based multilayer film","volume":"6","author":"Korposh","year":"2006","journal-title":"J. Biolog. Phys. Chem"},{"key":"ref_23","first-page":"179","article-title":"Nanoassembled thin-film gas sensor II. An intrinsic highly sensitive fibre-optic sensor for ammonia detection","volume":"21","author":"Korposh","year":"2009","journal-title":"Sensor. Mater"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.snb.2010.04.006","article-title":"Nano-assembled thin film gas sensors. IV. Mass-sensitive monitoring of humidity using quartz crystal microbalance (QCM) electrodes","volume":"147","author":"Korposh","year":"2010","journal-title":"Sens. Actuat. B"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1021\/ac901813q","article-title":"Nanoassembled thin film gas sensors. III. Sensitive detection of amine odors using TiO2\/Poly(acrylic acid) ultrathin film quartz crystal microbalance sensors","volume":"82","author":"Lee","year":"2010","journal-title":"Anal. Chem"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.snb.2007.09.044","article-title":"Olfactory systems for medical applications","volume":"130","author":"Paolesse","year":"2008","journal-title":"Sens. Actuat. B"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1021\/cr068121q","article-title":"Electronic nose: Current status and future trends","volume":"108","author":"Rock","year":"2008","journal-title":"Chem. Rev"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.snb.2009.02.009","article-title":"Fast-response surface acoustic wave humidity sensor based on hematoporphyrin film","volume":"137","author":"Rimeika","year":"2009","journal-title":"Sens. Actuat. B"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1049\/el:20071995","article-title":"Subsecond-response SAW humidity sensor with porphyrin nanostructure deposited on bare and metallised piezoelectric substrate","volume":"43","author":"Rimeika","year":"2007","journal-title":"Electron. Lett"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S0012-3692(15)33498-X","article-title":"Breathing patterns. 1. Normal subjects","volume":"84","author":"Tobin","year":"1983","journal-title":"Chest"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/sj.jhh.1001147","article-title":"Breathing-control lowers blood pressure","volume":"15","author":"Grossman","year":"2001","journal-title":"J. Hum. 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