{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T02:50:16Z","timestamp":1778813416690,"version":"3.51.4"},"reference-count":31,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2012,3,2]],"date-time":"2012-03-02T00:00:00Z","timestamp":1330646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>The preparation of a fluorogenic sensory material for the detection of biomolecules is described. Strategic functionalisation and copolymerisation of a water insoluble organic sensory molecule with hydrophilic comonomers yielded a crosslinked, water-swellable, easy-to-manipulate solid system for water \u2018\u2018dip-in\u2019\u2019 fluorogenic coenzyme A, cysteine, and glutathione detection by means of host-guest interactions. The sensory material was a membrane with gel-like behaviour, which exhibits a change in fluorescence behaviour upon swelling with a water solution of the target molecules. The membrane follows a \u201cturn-on\u201d pattern, which permits the titration of the abovementioned biomolecules. In this way, the water insoluble sensing motif can be exploited in aqueous media. The sensory motif within the membrane is a chemically anchored piperazinedione-derivative with a weakly bound Hg(II). The response is caused by the displacement of the cation from the membrane due to a stronger complexation with the biomolecules, thus releasing the fluorescent sensory moieties within the membrane.<\/jats:p>","DOI":"10.3390\/s120302969","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T07:40:22Z","timestamp":1330933222000},"page":"2969-2982","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["An Organic\/Inorganic Hybrid Membrane as a Solid \u201cTurn-On\u201d Fluorescent Chemosensor for Coenzyme A (CoA), Cysteine (Cys), and Glutathione (GSH) in Aqueous Media"],"prefix":"10.3390","volume":"12","author":[{"given":"Sa\u00fal","family":"Vallejos","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica, Facultad de Ciencias, Universidad de Burgos, Plaza de Misael Ba\u00f1uelos s\/n, E-09001 Burgos, Spain"}]},{"given":"Pedro","family":"Est\u00e9vez","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Facultad de Ciencias, Universidad de Burgos, Plaza de Misael Ba\u00f1uelos s\/n, E-09001 Burgos, Spain"}]},{"given":"Saturnino","family":"Ibeas","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Facultad de Ciencias, Universidad de Burgos, Plaza de Misael Ba\u00f1uelos s\/n, E-09001 Burgos, Spain"}]},{"given":"F\u00e9lix C.","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Facultad de Ciencias, Universidad de Burgos, Plaza de Misael Ba\u00f1uelos s\/n, E-09001 Burgos, Spain"}]},{"given":"Felipe","family":"Serna","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Facultad de Ciencias, Universidad de Burgos, Plaza de Misael Ba\u00f1uelos s\/n, E-09001 Burgos, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2674-8194","authenticated-orcid":false,"given":"Jos\u00e9 M.","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Facultad de Ciencias, Universidad de Burgos, Plaza de Misael Ba\u00f1uelos s\/n, E-09001 Burgos, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2012,3,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1080\/15583724.2011.616084","article-title":"Fluorogenic and chromogenic polymer chemosensors","volume":"51","author":"Serna","year":"2011","journal-title":"Polym. 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