{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T13:39:36Z","timestamp":1772113176854,"version":"3.50.1"},"reference-count":110,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T00:00:00Z","timestamp":1337558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>The LuxS enzyme, an S-ribosyl-homocysteine lyase, catalyzes the production of the signal precursor for autoinducer-2 mediated quorum sensing (QS-2) in Vibrio. Its widespread occurrence among bacteria is often considered the evidence for a universal language for interspecies communication. Presence of the luxS gene and production of the autoinducer-2 (AI-2) signal have repeatedly been the only evidences presented to assign a functional QS-2 to the most diverse species. In fact, LuxS has a primary metabolic role as part of the activated methyl cycle. In this review we have analyzed the distribution of QS-2 related genes in Enterobacteriaceae by moving the focus of the investigation from AI-2 production to the detection of potential AI-2 receptors. The latter are common in pathogens or endosymbionts of animals, but were also found in a limited number of Enterobacteriaceae of the genera Enterobacter, Klebsiella, and Pantoea that live in close association with plants or fungi. Although a precise function of QS-2 in these species has not been identified, they all show an endophytic or endosymbiontic lifestyle that suggests a role of type-2 quorum sensing in the adaptation to closed ecosystems.<\/jats:p>","DOI":"10.3390\/s120506645","type":"journal-article","created":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T11:24:56Z","timestamp":1337599496000},"page":"6645-6665","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Detection of AI-2 Receptors in Genomes of Enterobacteriaceae Suggests a Role of Type-2 Quorum Sensing in Closed Ecosystems"],"prefix":"10.3390","volume":"12","author":[{"given":"Fabio","family":"Rezzonico","sequence":"first","affiliation":[{"name":"Plant Protection Division, Agroscope Changins-W\u00e4denswil ACW, Schloss 1, W\u00e4denswil CH-8820, Switzerland"}]},{"given":"Theo H. M.","family":"Smits","sequence":"additional","affiliation":[{"name":"Plant Protection Division, Agroscope Changins-W\u00e4denswil ACW, Schloss 1, W\u00e4denswil CH-8820, Switzerland"}]},{"given":"Brion","family":"Duffy","sequence":"additional","affiliation":[{"name":"Plant Protection Division, Agroscope Changins-W\u00e4denswil ACW, Schloss 1, W\u00e4denswil CH-8820, Switzerland"}]}],"member":"1968","published-online":{"date-parts":[[2012,5,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev.micro.61.080706.093316","article-title":"Biofilm formation by plant-associated bacteria","volume":"61","author":"Danhorn","year":"2007","journal-title":"Annu. Rev. Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1574-6976.2001.tb00583.x","article-title":"Quorum-sensing in Gram-negative bacteria","volume":"25","author":"Whitehead","year":"2001","journal-title":"FEMS Microbiol. 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