{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:24:07Z","timestamp":1762251847843,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T00:00:00Z","timestamp":1339372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>This manuscript describes the use of a novel biochip platform for the rapid analysis\/identification of nucleic acids, including DNA and microRNAs, with very high specificity. This approach combines a unique dynamic chemistry approach for nucleic acid testing and analysis developed by DestiNA Genomics with the STMicroelectronics In-Check platform, which comprises two microfluidic optimized and independent PCR reaction chambers, and a sequential microarray area for nucleic acid capture and identification by fluorescence. With its compact bench-top \u201cfootprint\u201d requiring only a single technician to operate, the biochip system promises to transform and expand routine clinical diagnostic testing and screening for genetic diseases, cancers, drug toxicology and heart disease, as well as employment in the emerging companion diagnostics market.<\/jats:p>","DOI":"10.3390\/s120608100","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T11:00:59Z","timestamp":1339412459000},"page":"8100-8111","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Novel Biochip Platform for Nucleic Acid Analysis"],"prefix":"10.3390","volume":"12","author":[{"given":"Salvatore","family":"Pernagallo","sequence":"first","affiliation":[{"name":"DestiNA Genomics Ltd., West Mains Road, Edinburgh EH9 3JJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Ventimiglia","sequence":"additional","affiliation":[{"name":"STMicroelectronics, ANALOG, MEMS and SENSORS Group, Healthcare BDU, Stradale Primosole 50, Catania 95121, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Cavalluzzo","sequence":"additional","affiliation":[{"name":"DestiNA Genomics Ltd., West Mains Road, Edinburgh EH9 3JJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5710-2636","authenticated-orcid":false,"given":"Enrico","family":"Alessi","sequence":"additional","affiliation":[{"name":"STMicroelectronics, ANALOG, MEMS and SENSORS Group, Healthcare BDU, Stradale Primosole 50, Catania 95121, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh","family":"Ilyine","sequence":"additional","affiliation":[{"name":"DestiNA Genomics Ltd., West Mains Road, Edinburgh EH9 3JJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Bradley","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan J.","family":"Diaz-Mochon","sequence":"additional","affiliation":[{"name":"DestiNA Genomics Ltd., West Mains Road, Edinburgh EH9 3JJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2012,6,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nature05440","article-title":"Global health diagnostics","volume":"444","author":"Wasserman","year":"2006","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nature05448","article-title":"Requirements for high impact diagnostics in the developing world","volume":"444","author":"Urdea","year":"2006","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrmicro841","article-title":"Diagnostics for the developing world","volume":"2","author":"Mabey","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/nature05441","article-title":"Developing and interpreting models to improve diagnostics in developing countries","volume":"444","author":"Girosi","year":"2006","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0140-6736(08)61377-X","article-title":"Technology in global health: The need for essential diagnostics","volume":"372","author":"Houpt","year":"2008","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/446219a","article-title":"Tools for drug discovery: Tools of the trade","volume":"446","author":"Smith","year":"2007","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1128\/CMR.00019-09","article-title":"Basic concepts of microarrays and potential applications in clinical microbiology","volume":"22","author":"Miller","year":"2009","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev.bioeng.10.061807.160524","article-title":"Point-of-care diagnostics for global health","volume":"10","author":"Yager","year":"2008","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/nbt1208-1345","article-title":"Microfluidics closes in on point-of-care assays","volume":"26","author":"Sorger","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nrmicro2521","article-title":"Towards a point-of-care test for active tuberculosis: Obstacles and opportunities","volume":"9","author":"McNerney","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/37169","article-title":"Nucleic acid testing","volume":"390","author":"Horton","year":"1997","journal-title":"Nature"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.tibtech.2011.01.007","article-title":"Point-of-care nucleic acid testing for infectious diseases","volume":"29","author":"Niemz","year":"2011","journal-title":"Trends Biotechnol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1039\/B611455E","article-title":"Lab-on-a-chip devices for global health: Past studies and future opportunities","volume":"7","author":"Chin","year":"2007","journal-title":"Lab Chip"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/442367a","article-title":"Lab on a chip","volume":"442","author":"Daw","year":"2006","journal-title":"Nature"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5754","DOI":"10.3390\/s110605754","article-title":"Microfluidics-based lab-on-chip systems in DNA-based biosensing: An overview","volume":"11","author":"Dutse","year":"2011","journal-title":"Sensors"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.3390\/s90503713","article-title":"Nucleic acid-based detection of bacterial pathogens using integrated microfluidic platform systems","volume":"9","author":"Clarissa","year":"2009","journal-title":"Sensors"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1039\/b910586g","article-title":"A 1.5 mL microbial fuel cell for on-chip bioelectricity generation","volume":"9","author":"Qian","year":"2009","journal-title":"Lab Chip"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4804","DOI":"10.3390\/s90604804","article-title":"Microfluidic systems for pathogen sensing","volume":"9","author":"Mairhofer","year":"2009","journal-title":"Sensors"},{"key":"ref_19","unstructured":"Wang, W., and Vauchier, C. (,  2008). Develop the \u201cIn-Check\u201d Platform for Diagnostic Applications. Microfluidics, BioMEMS, and Medical Microsystems VI, San Jose, CA, USA."},{"key":"ref_20","first-page":"215","article-title":"Stability evaluation of protein coating for sensing: An application to silicon based lab-on-chip device","volume":"137","author":"Petralia","year":"2012","journal-title":"Sens. Transducers J."},{"key":"ref_21","unstructured":"Ventimiglia, G., and Petralia, S. (2011). Inorganic nanoparticles properties, applications and production photosynthetic routes. Recent Res. Devel. Photochem. Photobiol., in press."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ab.2006.03.019","article-title":"Polymerase chain reaction of 2-kb cyanobacterial gene and human anti-\u03b11-chymotrypsin gene from genomic DNA on the In-Check single-use microfabricated silicon chip","volume":"353","author":"Consolandi","year":"2006","journal-title":"Anal. Biochem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1515\/CCLM.2010.063","article-title":"Integrated PCR amplification and detection processes on a Lab-on-Chip platform: A new advanced solution for molecular diagnostics","volume":"48","author":"Foglieni","year":"2010","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1007\/s00705-011-0999-7","article-title":"VereFlu\u2122: An integrated multiplex RT-PCR and microarray assay for rapid detection and identification of human influenza A and B viruses using lab-on-chip technology","volume":"156","author":"Teo","year":"2011","journal-title":"Arch. Virol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1039\/c1ay05176h","article-title":"Dynamic chemistry for enzyme-free allele discrimination in genotyping by MALDI-TOF mass spectrometry","volume":"3","author":"Bowler","year":"2011","journal-title":"Anal. Methods"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1002\/anie.200905699","article-title":"DNA Analysis by dynamic chemistry","volume":"49","author":"Bowler","year":"2010","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_27","unstructured":"Diaz-Mochon, J.J., and Bradley, M. (2008). Nucleobase Characterisation. (WO Patent WO2009\/037473)."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1002\/hep.24538","article-title":"Circulating microRNAs as potential markers of human drug-induced liver injury","volume":"54","author":"Dear","year":"2011","journal-title":"Hepatology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"7350","DOI":"10.1128\/AEM.01177-09","article-title":"Risk assessment in shellfish-borne outbreaks of hepatitis A","volume":"75","author":"Costafreda","year":"2009","journal-title":"Appl. Environ. Microbiol."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/12\/6\/8100\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:50:43Z","timestamp":1760219443000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/12\/6\/8100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,11]]},"references-count":29,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,6]]}},"alternative-id":["s120608100"],"URL":"https:\/\/doi.org\/10.3390\/s120608100","relation":{},"ISSN":["1424-8220"],"issn-type":[{"type":"electronic","value":"1424-8220"}],"subject":[],"published":{"date-parts":[[2012,6,11]]}}}