{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:34:28Z","timestamp":1760243668271,"version":"build-2065373602"},"reference-count":13,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2012,7,17]],"date-time":"2012-07-17T00:00:00Z","timestamp":1342483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>In this paper, a novel signal processing circuit which can be used for the measurement of H+ ion and urea concentration is presented. A potentiometric method is used to detect the concentrations of H+ ions and urea by using H+ ion-selective electrodes and urea electrodes, respectively. The experimental data shows that this measuring structure has a linear pH response for the concentration range within pH 2 and 12, and the dynamic range for urea concentration measurement is in the range of 0.25 to 64 mg\/dL. The designed instrumentation circuit possesses a calibration function and it can be applied to different sensing electrodes for electrochemical analysis. It possesses the advantageous properties of being multi-purpose, easy calibration and low cost.<\/jats:p>","DOI":"10.3390\/s120709687","type":"journal-article","created":{"date-parts":[[2012,7,17]],"date-time":"2012-07-17T12:25:04Z","timestamp":1342527904000},"page":"9687-9696","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Novel Instrumentation Circuit for Electrochemical Measurements"],"prefix":"10.3390","volume":"12","author":[{"given":"Li-Te","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Optometry, Chung Hwa University of Medical Technology, Tainan 717, Taiwan"}]},{"given":"Hung-Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering, National Kaohsiung University of Applied Science, Kaohsiung 807, Taiwan"}]},{"given":"Yang-Chiuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering, National Kaohsiung University of Applied Science, Kaohsiung 807, Taiwan"}]},{"given":"Wen-Chung","family":"Huang","sequence":"additional","affiliation":[{"name":"General Education Center, Chung Hwa University of Medical Technology, Tainan 717, Taiwan"}]}],"member":"1968","published-online":{"date-parts":[[2012,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1749-6632.1962.tb13623.x","article-title":"Electrode system for continuous monitoring in cardiovascular surgery","volume":"102","author":"Clark","year":"1962","journal-title":"Ann. 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