{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:07:07Z","timestamp":1777489627013,"version":"3.51.4"},"reference-count":23,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T00:00:00Z","timestamp":1349654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>CD105 is a well-known tumor metastasis marker and useful for early monitoring of metastasis and cancer relapse. It is important to generate rapid, reliable and precise analytical information regarding CD105 levels. To establish a simple, selective and sensitive detection method, we prepared an immunosensor with novel bioconjugates based on Pt nanoparticles, thionin acetate and antibodies. The proposed immunosensor displayed a broader linear response to CD105, with a working range of 1.3 to 200.0 ng\/mL and a detection limit of 0.9 ng\/mL under optimal conditions. Moreover, the studied immunosensor exhibited high sensitivity, fast analysis and adequate stability. The proposed methodology could readily be extended to other clinical- or environment-related biospecies.<\/jats:p>","DOI":"10.3390\/s121013471","type":"journal-article","created":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T11:03:30Z","timestamp":1349694210000},"page":"13471-13479","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Novel CD105 Determination System Based on an Ultrasensitive Bioelectrochemical Strategy with Pt Nanoparticles"],"prefix":"10.3390","volume":"12","author":[{"given":"Suyun","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Obstetrics & Gynecology, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing 400038, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical engineering, Chongqing University, 174 Shazhengjie, Shapingba District, Chongqing 400044, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing 400038, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing 400038, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenbo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing 400038, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqing","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing 400038, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2012,10,8]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Tumor invasion and metastases role of the extracellular matrix: Rhoads Memorial Award lecture","volume":"46","author":"Liotta","year":"1986","journal-title":"Cancer Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1093\/jnci\/89.17.1260","article-title":"Changing views of the role of matrix metalloproteinases in metastasis","volume":"89","author":"Chambers","year":"1997","journal-title":"J. Nat. Cancer Inst (Bethesda)"},{"key":"ref_3","unstructured":"Devita, V.T., Hellman, S., and Rosenberg, S.A. (1997). Cancer: Principles and Practice of Oncology, Lippincott-Raven Publishers. [5th ed.]."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1093\/jnci\/91.16.1351","article-title":"What defines a useful marker of metastasis in human cancer","volume":"91","author":"Welch","year":"1999","journal-title":"J. Nat. Cancer Inst (Bethesda)"},{"key":"ref_5","first-page":"4675","article-title":"Expression of a novel factor in human breast cancer cells with metastatic potential","volume":"59","author":"Ree","year":"1999","journal-title":"Cancer Res."},{"key":"ref_6","first-page":"1950","article-title":"Molecular detection of micrometastases and circulating tumor cells in solid tumors","volume":"5","author":"Ghossein","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/ijc.10462","article-title":"Strategies for vascular targeting in tumours","volume":"100","author":"Brekken","year":"2002","journal-title":"Int. J. Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"43799","DOI":"10.1074\/jbc.M207160200","article-title":"Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways","volume":"277","author":"Botella","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1158\/1078-0432.CCR-07-4478","article-title":"Endoglin (CD105): A marker of tumor vasculature and potential target for therapy","volume":"14","author":"Nikolaos","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1365-2559.2011.04166.x","article-title":"Microvascular endoglin (CD105) expression correlates with tissue markers for atherosclerotic plaque vulnerability in an ageing population with multivessel coronary artery disease","volume":"1","author":"Li","year":"2012","journal-title":"Histopathology"},{"key":"ref_11","first-page":"12","article-title":"Targeting cancer vasculature via endoglin\/CD105: A novel antibody-based diagnostic and therapeutic strategy in solid tumours","volume":"1","author":"Ester","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"ref_12","first-page":"524","article-title":"Association of serum endoglin with metastasis in patients with colorectal, breast, and other solid tumors, and suppressive effect of chemotherapy on the serum Endoglin","volume":"7","author":"Norihiko","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1096\/fj.02-0634rev","article-title":"CD105 is important for angiogenesis: Evidence and potential applications","volume":"17","author":"Duff","year":"2003","journal-title":"FASEB J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0925-4005(99)00081-7","article-title":"Immunosensors based on supported lipid membranes, protein films and liposomes modified by antibodies","volume":"57","author":"Hianik","year":"1999","journal-title":"Sens. Actuators B"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1016\/j.electacta.2003.12.028","article-title":"Horseradish peroxidase immobilized in TiO nanoparticle films on pyrolytic graphite electrodes: Direct electrochemistry and bioelectrocatalysis","volume":"49","author":"Zhang","year":"2004","journal-title":"Electrochim. Acta"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.snb.2005.02.011","article-title":"A reusable capacitive immunosensor with a novel immobilization procedure based on 1,6-hexanedithiol and nano-Au self-assembled layers","volume":"110","author":"Li","year":"2005","journal-title":"Sens. Actuators B"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1021\/la0487242","article-title":"Investigation of Ig.G adsorption and the effect on electrochemical responses at titanium dioxide electrode","volume":"21","author":"Moulton","year":"2005","journal-title":"Langmuir"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1016\/j.electacta.2006.10.031","article-title":"Development of an amperometric immunosensor based on TiO nanoparticles and gold nanoparticles","volume":"52","author":"Shi","year":"2007","journal-title":"Electrochim. Acta"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1016\/j.electacta.2007.09.057","article-title":"A novel label-free voltammetric immunosensor for the detection of \u03b1-fetoprotein using functional titanium dioxide nanoparticles","volume":"53","author":"Liang","year":"2008","journal-title":"Electrochim. Acta"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1016\/j.bios.2010.04.013","article-title":"Organic electrochemical transistor based immunosensor for prostate specific antigen (PSA) detection using gold nanoparticles for signal amplification","volume":"25","author":"Kim","year":"2010","journal-title":"Biosens. Bioelectron."},{"key":"ref_21","unstructured":"Abcam Co. Available online: http:\/\/www.abcam.com\/CD105-Human-ELISA-Kit-1-x-96-Well-Plate-ab100507.html (accessed on 1 August 2011)."},{"key":"ref_22","first-page":"524","article-title":"Association of serum endoglin with metastasis in patients with colorectal, breast, and other solid tumors, and suppressive effect of chemotherapy on the serum Endoglin","volume":"7","author":"Norihiko","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.bios.2010.08.023","article-title":"Amplification strategy based on gold nanoparticle-decorated carbon nanotubes for neomycin immunosensors","volume":"25","author":"Zhu","year":"2010","journal-title":"Biosens. Bioelectron."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/12\/10\/13471\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:52:42Z","timestamp":1760219562000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/12\/10\/13471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,8]]},"references-count":23,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2012,10]]}},"alternative-id":["s121013471"],"URL":"https:\/\/doi.org\/10.3390\/s121013471","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,8]]}}}