{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:19:53Z","timestamp":1790842793735,"version":"4.1.0"},"reference-count":60,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T00:00:00Z","timestamp":1362700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>We have developed a fluorescence-based fiber-optical biosensor, which can selectively detect different antibodies in serial at preselected positions inside a single piece of fiber. The fiber is a microstructured polymer optical fiber fabricated from TOPAS cyclic olefin copolymer, which allows for UV activation of localized sensor layers inside the holes of the fiber. Serial fluorescence-based selective sensing of Cy3-labelled \u03b1-streptavidin and Cy5-labelled \u03b1-CRP antibodies is demonstrated.<\/jats:p>","DOI":"10.3390\/s130303242","type":"journal-article","created":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T11:22:13Z","timestamp":1362741733000},"page":"3242-3251","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":121,"title":["Selective Serial Multi-Antibody Biosensing with TOPAS Microstructured Polymer Optical Fibers"],"prefix":"10.3390","volume":"13","author":[{"given":"Grigoriy","family":"Emiliyanov","sequence":"first","affiliation":[{"name":"DTU Fotonik, Department of Photonics Engineering, Technical University of Denmark,  \u00d8rsteds Plads, 2800 Kgs. Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poul","family":"H\u00f8iby","sequence":"additional","affiliation":[{"name":"DAKO Denmark A\/S, Produktionsvej 42, DK-2600 Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Bioneer A\/S, Kogle All\u00e9 2, 2970 H\u00f8rsholm, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Bang","sequence":"additional","affiliation":[{"name":"DTU Fotonik, Department of Photonics Engineering, Technical University of Denmark,  \u00d8rsteds Plads, 2800 Kgs. Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2013,3,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3390\/s7060797","article-title":"Recent developments in optical fiber biosensors","volume":"70","author":"Bosch","year":"2007","journal-title":"Sensors"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.aca.2008.05.022","article-title":"Sensitive optical biosensors for unlabeled targets: A review","volume":"620","author":"Fan","year":"2008","journal-title":"Anal. Chim. Acta"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1007\/s00216-006-0480-8","article-title":"Towards biochips using microstructured optical fiber sensors","volume":"385","author":"Rindorf","year":"2006","journal-title":"Anal. Bioanal. 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