{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T19:32:47Z","timestamp":1771615967660,"version":"3.50.1"},"reference-count":145,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T00:00:00Z","timestamp":1364428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>A cellular-level study of the pathophysiology is crucial for understanding the mechanisms behind human diseases. Recent advances in quantitative phase imaging (QPI) techniques show promises for the cellular-level understanding of the pathophysiology of diseases. To provide important insight on how the QPI techniques potentially improve the study of cell pathophysiology, here we present the principles of QPI and highlight some  of the recent applications of QPI ranging from cell homeostasis to infectious diseases  and cancer.<\/jats:p>","DOI":"10.3390\/s130404170","type":"journal-article","created":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T13:35:44Z","timestamp":1364477744000},"page":"4170-4191","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":481,"title":["Quantitative Phase Imaging Techniques for the Study of Cell Pathophysiology: From Principles to Applications"],"prefix":"10.3390","volume":"13","author":[{"given":"KyeoReh","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea"}]},{"given":"Kyoohyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea"}]},{"given":"Jaehwang","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea"}]},{"given":"JiHan","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea"}]},{"given":"Sangyeon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea"}]},{"given":"Sangyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea"}]},{"given":"Gyuyoung","family":"Chang","sequence":"additional","affiliation":[{"name":"Hankuk Academy of Foreign Studies, Yongin 449-854, Korea"}]},{"given":"YoungJu","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea"}]},{"given":"Hyunjoo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea"}]},{"given":"YongKeun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea"}]}],"member":"1968","published-online":{"date-parts":[[2013,3,28]]},"reference":[{"key":"ref_1","unstructured":"Popescu, G. (2011). Quantitative Phase Imaging of Cells and Tissues, McGraw-Hill Professional."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"8263","DOI":"10.1364\/OE.14.008263","article-title":"Diffraction phase and fluorescence microscopy","volume":"14","author":"Park","year":"2006","journal-title":"Opt. Express"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.1364\/OL.34.003668","article-title":"Spectroscopic phase microscopy for quantifying hemoglobin concentrations in intact red blood cells","volume":"34","author":"Park","year":"2009","journal-title":"Opt. Lett."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"9948","DOI":"10.1364\/OE.20.009948","article-title":"Polarization holographic microscopy for extracting spatio-temporally resolved Jones matrix","volume":"20","author":"Kim","year":"2012","journal-title":"Opt. Express"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"13327","DOI":"10.1021\/jp904746r","article-title":"Live cell refractometry using hilbert phase microscopy and confocal reflectance microscopy","volume":"113","author":"Lue","year":"2009","journal-title":"J. Phys. Chem. A"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"A52","DOI":"10.1364\/AO.47.000A52","article-title":"Digital holographic microscopy for live cell applications and technical inspection","volume":"47","author":"Kemper","year":"2008","journal-title":"Appl. Opt."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.1364\/OL.37.005094","article-title":"Accelerated autofocusing of off-axis holograms using critical sampling","volume":"37","author":"Fatih","year":"2012","journal-title":"Opt. Lett."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1364\/OL.29.002399","article-title":"Quantitative phase imaging using actively stabilized phase-shifting low-coherence interferometry","volume":"29","author":"Iwai","year":"2004","journal-title":"Opt. Lett."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1364\/OL.30.000468","article-title":"Digital holographic microscopy: A noninvasive contrast imaging technique allowing quantitative visualization of living cells with subwavelength axial accuracy","volume":"30","author":"Marquet","year":"2005","journal-title":"Opt. Lett."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1364\/OL.31.000775","article-title":"Diffraction phase microscopy for quantifying cell structure and dynamics","volume":"31","author":"Popescu","year":"2006","journal-title":"Opt. Lett."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1364\/OL.32.001572","article-title":"Imaging voltage-dependent cell motions with heterodyne Mach-Zehnder phase microscopy","volume":"32","author":"Oh","year":"2007","journal-title":"Opt. Lett."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nmeth1078","article-title":"Tomographic phase microscopy","volume":"4","author":"Choi","year":"2007","journal-title":"Nat. Methods"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1364\/AO.41.000027","article-title":"Polarization imaging by use of digital holography","volume":"41","author":"Colomb","year":"2002","journal-title":"Appl. Opt."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.1364\/AO.40.006177","article-title":"Image formation in phase-shifting digital holography and applications to microscopy","volume":"40","author":"Yamaguchi","year":"2001","journal-title":"Appl. Opt."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Kemper, B., Vollmer, A., Rommel, C.E., Schnekenburger, J., and von Bally, G. (2011). Simplified approach for quantitative digital holographic phase contrast imaging of living cells. J. Biomed. Opt., 16.","DOI":"10.1117\/1.3540674"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1364\/OL.37.005127","article-title":"Quantitative phase-contrast imaging with compact digital holographic microscope employing Lloyd's mirror","volume":"37","author":"Chhaniwal","year":"2012","journal-title":"Opt. Lett."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1364\/OL.29.002503","article-title":"Fourier phase microscopy for investigation of biological structures and dynamics","volume":"29","author":"Popescu","year":"2004","journal-title":"Opt. Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1364\/OE.19.001016","article-title":"Spatial light interference microscopy (SLIM)","volume":"19","author":"Wang","year":"2011","journal-title":"Opt. Express"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"13080","DOI":"10.1364\/OE.17.013080","article-title":"Quadriwave lateral shearing interferometry for quantitative phase microscopy of living cells","volume":"17","author":"Bon","year":"2009","journal-title":"Opt. Express"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"11301","DOI":"10.1073\/pnas.191361398","article-title":"Digital in-line holography for biological applications","volume":"98","author":"Xu","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1364\/OL.30.001165","article-title":"Hilbert phase microscopy for investigating fast dynamics in transparent systems","volume":"30","author":"Ikeda","year":"2005","journal-title":"Opt. Lett."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Kim, M.K. (2011). Digital Holography and Microscopy: Principles, Techniques and Applications, Springer Verlag.","DOI":"10.1007\/978-1-4419-7793-9"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4704","DOI":"10.1364\/OL.36.004704","article-title":"Laplace field microscopy for label-free imaging of dynamic biological structures","volume":"36","author":"Kim","year":"2011","journal-title":"Opt. Lett."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6737","DOI":"10.1364\/OE.20.006737","article-title":"Gradient field microscopy of unstained specimens","volume":"20","author":"Kim","year":"2012","journal-title":"Opt. Express"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.1364\/OE.14.003792","article-title":"Quantitative imaging of complex samples by spiral phase contrast microscopy","volume":"14","author":"Bernet","year":"2006","journal-title":"Opt. Express"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1080\/09500349514551621","article-title":"A novel technique for spatial phase-shifting interferometry","volume":"42","author":"Servin","year":"1995","journal-title":"J. Mod. Opt."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1364\/JOSA.72.000156","article-title":"Fourier-transform method of fringe-pattern analysis for computer-based topography and interferometry","volume":"72","author":"Takeda","year":"1982","journal-title":"J. Opt. Soc. Am. A"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1364\/OL.36.004677","article-title":"Real-time quantitative phase imaging with a spatial phase-shifting algorithm","volume":"36","author":"Debnath","year":"2011","journal-title":"Opt. Lett."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1364\/OL.37.001868","article-title":"Derivative method for phase retrieval in off-axis quantitative phase imaging","volume":"37","author":"Bhaduri","year":"2012","journal-title":"Opt. Lett."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1364\/OL.23.000817","article-title":"Quantitative optical phase microscopy","volume":"23","author":"Barty","year":"1998","journal-title":"Opt. Lett."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1364\/OL.35.000447","article-title":"Transport-of-intensity approach to differential interference contrast (TI-DIC) microscopy for quantitative phase imaging","volume":"35","author":"Kou","year":"2010","journal-title":"Opt. Lett."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"22817","DOI":"10.1364\/OE.18.022817","article-title":"Phase from chromatic aberrations","volume":"18","author":"Waller","year":"2010","journal-title":"Opt. Express"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1364\/OL.35.001028","article-title":"Phase microscopy of technical and biological samples through random phase modulation with a diffuser","volume":"35","author":"Almoro","year":"2010","journal-title":"Opt. Lett."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1364\/OL.36.002671","article-title":"Quantitative phase restoration by direct inversion using the optical transfer function","volume":"36","author":"Kou","year":"2011","journal-title":"Opt. Lett."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Levin, G.G., Vishnyakov, G.N., Zakarian, C.S., Likhachov, A.V., Pickalov, V.V., Kozinets, G.I., Novoderzhkina, J.K., and Streletskaya, E.A. (1998). Three-dimensional limited-angle microtomography of blood cells: Experimental results. Proc. SPIE, 159.","DOI":"10.1117\/12.310549"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1046\/j.0022-2720.2001.00980.x","article-title":"New approach to optical diffraction tomography yielding a vector equation of diffraction tomography and a novel tomographic microscope","volume":"205","author":"Lauer","year":"2002","journal-title":"J. Microsc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1051\/epjap:2008049","article-title":"Tomographic diffractive microscopy of transparent samples","volume":"44","author":"Simon","year":"2008","journal-title":"Eur. Phys. J. Appl. Phys."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Isikman, S.O., Bishara, W., Mavandadi, S., Yu, F.W., Feng, S., Lau, R., and Ozcan, A. (2011). Lens-free optical tomographic microscope with a large imaging volume on a chip. Proc. Natl. Acad. Sci. USA, 108.","DOI":"10.1073\/pnas.1015638108"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1364\/OL.31.000178","article-title":"Cell refractive index tomography by digital holographic microscopy","volume":"31","author":"Charriere","year":"2006","journal-title":"Opt. Lett."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1364\/OPEX.13.004210","article-title":"Three-dimensional imaging of single isolated cell nuclei using optical projection tomography","volume":"13","author":"Fauver","year":"2005","journal-title":"Opt. Express"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1364\/OL.30.002092","article-title":"Wavelength-scanning digital interference holography for tomographic three-dimensional imaging by use of the angular spectrum method","volume":"30","author":"Yu","year":"2005","journal-title":"Opt. Lett."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1364\/OL.34.000653","article-title":"Submicrometer tomography of cells by multiple-wavelength digital holographic microscopy in reflection","volume":"34","author":"Montfort","year":"2009","journal-title":"Opt. Lett."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Phillips, K.G., Jacques, S.L., and McCarty, O.J. (2012). Measurement of single cell refractive index, dry mass, volume, and density using a transillumination microscope. Phys. Rev. Lett., 109.","DOI":"10.1103\/PhysRevLett.109.118105"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1364\/JOSAA.12.001942","article-title":"Partially coherent fields, the transport-of-intensity equation, and phase uniqueness","volume":"12","author":"Gureyev","year":"1995","journal-title":"JOSA A"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Kak, A.C., and Slaney, M. (2001). Principles of Computerized Tomographic Imaging, Society for Industrial and Applied Mathematics.","DOI":"10.1137\/1.9780898719277"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0030-4018(69)90052-2","article-title":"Three-dimensional structure determination of semi-transparent objects from holographic data","volume":"1","author":"Wolf","year":"1969","journal-title":"Opt. Commun"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1364\/OL.6.000374","article-title":"Inverse-scattering theory within the rytov approximation","volume":"6","author":"Devaney","year":"1981","journal-title":"Opt. Lett."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1364\/OE.17.000266","article-title":"Optical diffraction tomography for high resolution live cell imaging","volume":"17","author":"Sung","year":"2009","journal-title":"Opt. Express"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1364\/OL.25.001526","article-title":"Interferometric phase-dispersion microscopy","volume":"25","author":"Yang","year":"2000","journal-title":"Opt. Lett."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1364\/OL.26.000686","article-title":"Phase-dispersion optical tomography","volume":"26","author":"Yang","year":"2001","journal-title":"Opt. Lett."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1364\/OL.30.001162","article-title":"Spectral-domain phase microscopy","volume":"30","author":"Choma","year":"2005","journal-title":"Opt. Lett."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1364\/OL.37.003438","article-title":"Spectroscopic diffraction phase microscopy","volume":"37","author":"Pham","year":"2012","journal-title":"Opt. Lett."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"9673","DOI":"10.1364\/OE.20.009673","article-title":"Dynamic spectroscopic phase microscopy for quantifying hemoglobin concentration and dynamic membrane fluctuation in red blood cells","volume":"20","author":"Jang","year":"2012","journal-title":"Opt. Express"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1364\/OL.33.001270","article-title":"Jones phase microscopy of transparent and anisotropic samples","volume":"33","author":"Wang","year":"2008","journal-title":"Opt. Lett."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"A103","DOI":"10.1364\/AO.47.00A103","article-title":"Harmonic holography: A new holographic principle","volume":"47","author":"Pu","year":"2008","journal-title":"Appl. Opt."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1364\/OL.35.004102","article-title":"Label-free second-harmonic phase imaging of biological specimen by digital holographic microscopy","volume":"35","author":"Shaffer","year":"2010","journal-title":"Opt. Lett."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"9811","DOI":"10.1364\/OE.16.009811","article-title":"Digital holography of total internal reflection","volume":"16","author":"Ash","year":"2008","journal-title":"Opt. Express"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1364\/OL.32.000811","article-title":"Fresnel particle tracing in three dimensions using diffraction phase microscopy","volume":"32","author":"Park","year":"2007","journal-title":"Opt. Lett."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1364\/AO.44.001806","article-title":"Time-domain optical coherence tomography with digital holographic microscopy","volume":"44","author":"Massatsch","year":"2005","journal-title":"Appl. Opt."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1364\/OL.36.002390","article-title":"Holoscopy\u2014Holographic optical coherence tomography","volume":"36","author":"Hillmann","year":"2011","journal-title":"Opt. Lett."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1364\/BOE.2.002484","article-title":"Combined confocal Raman and quantitative phase microscopy system for biomedical diagnosis","volume":"2","author":"Kang","year":"2011","journal-title":"Biomed. Opt. Express"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/jbio.201000018","article-title":"Cell morphology and intracellular ionic homeostasis explored with a multimodal approach combining epifluorescence and digital holographic microscopy","volume":"3","author":"Pavillon","year":"2010","journal-title":"J. Biophotonics"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1364\/OL.32.000623","article-title":"Spectral-domain optical coherence phase and multiphoton microscopy","volume":"32","author":"Joo","year":"2007","journal-title":"Opt. Lett."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Ding, H., Wang, Z., Nguyen, F., Boppart, S.A., and Popescu, G. (2008). Fourier transform light scattering of inhomogeneous and dynamic structures. Phys. Rev. Lett., 101.","DOI":"10.1103\/PhysRevLett.101.238102"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1109\/JSTQE.2009.2034752","article-title":"Fourier transform light scattering of biological structure and dynamics","volume":"16","author":"Ding","year":"2010","journal-title":"IEEE J. Sel. Top. Quantum Electr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1166\/jctn.2010.1637","article-title":"Fourier Transform Light Scattering (FTLS) of cells and tissues","volume":"7","author":"Ding","year":"2010","journal-title":"J. Comput. Theor. Nanosci."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Park, Y.K., Best-Popescu, C.A., Dasari, R.R., and Popescu, G. (2011). Light scattering of human red blood cells during metabolic remodeling of the membrane. J. Biomed. Opt., 16.","DOI":"10.1117\/1.3524509"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Park, Y.K., Diez-Silva, M., Fu, D., Popescu, G., Choi, W., Barman, I., Suresh, S., and Feld, M.S. (2010). Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells. J. Biomed. Opt., 15.","DOI":"10.1117\/1.3369966"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"18878","DOI":"10.1364\/OE.17.018878","article-title":"Ultraviolet refractometry using field-based light scattering spectroscopy","volume":"17","author":"Fu","year":"2009","journal-title":"Opt. Express"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1364\/OL.37.002577","article-title":"Fourier-transform light scattering of individual colloidal clusters","volume":"37","author":"Yu","year":"2012","journal-title":"Opt. Lett."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1364\/OL.37.004161","article-title":"Fourier-transform light scattering angular spectroscopy using digital in-line holography","volume":"37","author":"Kim","year":"2012","journal-title":"Opt. Lett."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.optlaseng.2008.03.007","article-title":"Characterisation of light emitting diodes (LEDs) for application in digital holographic microscopy for inspection of micro and nanostructured surfaces","volume":"46","author":"Kemper","year":"2008","journal-title":"Opt. Lasers Eng."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bpj.2012.05.020","article-title":"Label-Free imaging of membrane potential using membrane electromotility","volume":"103","author":"Oh","year":"2012","journal-title":"Biophys. J"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1364\/OL.37.001094","article-title":"Diffraction phase microscopy with white light","volume":"37","author":"Bhaduri","year":"2012","journal-title":"Opt. Lett."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1364\/AO.43.001131","article-title":"Partial spatial coherence effects in digital holographic microscopy with a laser source","volume":"43","author":"Dubois","year":"2004","journal-title":"Appl. Opt."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"12285","DOI":"10.1364\/OE.17.012285","article-title":"Speckle-field digital holographic microscopy","volume":"17","author":"Park","year":"2009","journal-title":"Opt. Express"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bcmd.2008.01.010","article-title":"Imaging red blood cell dynamics by quantitative phase microscopy","volume":"41","author":"Popescu","year":"2008","journal-title":"Blood Cells Mol. Dis."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"13730","DOI":"10.1073\/pnas.0806100105","article-title":"Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum","volume":"105","author":"Park","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1073\/pnas.0910785107","article-title":"Metabolic remodeling of the human red blood cell membrane","volume":"107","author":"Park","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"6731","DOI":"10.1073\/pnas.0909533107","article-title":"Measurement of red blood cell mechanics during morphological changes","volume":"107","author":"Park","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1364\/BOE.2.003259","article-title":"Blood testing at the single cell level using quantitative phase and amplitude microscopy","volume":"2","author":"Mir","year":"2011","journal-title":"Biomed. Opt. Express"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"13124","DOI":"10.1073\/pnas.1100506108","article-title":"Optical measurement of cycle-dependent cell growth","volume":"108","author":"Mir","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Park, Y.K., Best, C.A., Kuriabova, T., Henle, M.L., Feld, M.S., Levine, A.J., and Popescu, G. (2011). Measurement of the nonlinear elasticity of red blood cell membranes. Phys. Rev. E, 83.","DOI":"10.1103\/PhysRevE.83.051925"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"11846","DOI":"10.1523\/JNEUROSCI.0286-11.2011","article-title":"Determination of transmembrane water fluxes in neurons elicited by glutamate ionotropic receptors and by the cotransporters KCC2 and NKCC1: A digital holographic microscopy study","volume":"31","author":"Jourdain","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1364\/BOE.1.000706","article-title":"Whole-cell-analysis of live cardiomyocytes using wide-field interferometric phase microscopy","volume":"1","author":"Shaked","year":"2010","journal-title":"Biomed. Opt. Express"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Chandramohanadas, R., Park, Y., Lui, L., Li, A., Quinn, D., Liew, K., Diez-Silva, M., Sung, Y., Dao, M., and Lim, C.T. (2011). Biophysics of malarial parasite exit from infected erythrocytes. PLoS One, 6.","DOI":"10.1371\/journal.pone.0020869"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Sung, Y., Choi, W., Lue, N., Dasari, R.R., and Yaqoob, Z. (2012). Stain-free quantification of chromosomes in live cells using regularized tomographic phase microscopy. PLoS One, 7.","DOI":"10.1371\/journal.pone.0049502"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"19462","DOI":"10.1364\/OE.18.019462","article-title":"Microscopy image resolution improvement by deconvolution of complex fields","volume":"18","author":"Cotte","year":"2010","journal-title":"Opt. Express"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Mir, M., Babacan, S.D., Bednarz, M., Do, M.N., Golding, I., and Popescu, G. (2012). Visualizing escherichia coli sub-cellular structure using sparse deconvolution spatial light interference tomography. PLoS One, 7.","DOI":"10.1371\/journal.pone.0039816"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1364\/OL.32.003522","article-title":"Tissue refractometry using Hilbert phase microscopy","volume":"32","author":"Lue","year":"2007","journal-title":"Opt. Lett."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Wang, Z., Tangella, K., Balla, A., and Popescu, G. (2011). Tissue refractive index as marker of disease. J. Biomed. Opt., 16.","DOI":"10.1117\/1.3656732"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1364\/OL.36.002281","article-title":"Measuring the scattering parameters of tissues from quantitative phase imaging of thin slices","volume":"36","author":"Ding","year":"2011","journal-title":"Opt. Lett."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1364\/OL.34.001372","article-title":"Optical properties of tissues quantified by Fourier-transform light scattering","volume":"34","author":"Ding","year":"2009","journal-title":"Opt. Lett."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/1721097a0","article-title":"Determination of dry mass, thickness, solid and water concentration in living cells","volume":"172","author":"Barer","year":"1953","journal-title":"Nature"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"C538","DOI":"10.1152\/ajpcell.00121.2008","article-title":"Optical imaging of cell mass and growth dynamics","volume":"295","author":"Popescu","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Rappaz, B., Cano, E., Colomb, T., Kuhn, J., Depeursinge, C., Simanis, V., Magistretti, P.J., and Marquet, P. (2009). Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopy. J. Biomed. Opt., 14.","DOI":"10.1117\/1.3147385"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"20691","DOI":"10.1073\/pnas.1011365107","article-title":"Measurement of adherent cell mass and growth","volume":"107","author":"Park","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1364\/BOE.2.002815","article-title":"Simultaneous optical measurements of cell motility and growth","volume":"2","author":"Sridharan","year":"2011","journal-title":"Biomed. Opt. Express"},{"key":"ref_99","unstructured":"Park, Y., Best, C.A., and Popescu, G. (2011). Mechanobiology Of Cell-Cell and Cell-Matrix Interactions, Springer."},{"key":"ref_100","first-page":"625","article-title":"Further observation of motion phenomena on red blood cells in pathological states","volume":"28","author":"Browicz","year":"1890","journal-title":"Zbl. Med. Wissen"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Popescu, G., Ikeda, T., Best, C.A., Badizadegan, K., Dasari, R.R., and Feld, M.S. (2005). Erythrocyte structure and dynamics quantified by Hilbert phase microscopy. J. Biomed. Opt., 10.","DOI":"10.1117\/1.2149847"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/cyto.a.20605","article-title":"Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzer","volume":"73","author":"Rappaz","year":"2008","journal-title":"Cytom. Part A"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Popescu, G., Park, Y.K., Dasari, R.R., Badizadegan, K., and Feld, M.S. (2007). Coherence properties of red blood cell membrane motions. Phys. Rev. E., 76.","DOI":"10.1103\/PhysRevE.76.031902"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Popescu, G., Badizadegan, K., Dasari, R., and Feld, M. (2006). Observation of dynamic subdomains in red blood cells. J. Biomed. Opt., 11.","DOI":"10.1117\/1.2221867"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Ben-Isaac, E., Park, Y.K., Popescu, G., Brown, F.L.H., Gov, N.S., and Shokef, Y. (2011). Effective temperature of red-blood-cell membrane fluctuations. Phys. Rev. Lett., 106.","DOI":"10.1103\/PhysRevLett.106.238103"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"e40667","DOI":"10.1371\/journal.pone.0040667","article-title":"Spatially-resolved eigenmode decomposition of red blood cells membrane fluctuations questions the role of atp in flickering","volume":"7","author":"Boss","year":"2012","journal-title":"PLoS One"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Moschandreou, T.E. (2012). Blood Cell\u2014An Overview of Studies in Hematology, INTECH.","DOI":"10.5772\/2979"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Popescu, G., Ikeda, T., Goda, K., Best-Popescu, C.A., Laposata, M., Manley, S., Dasari, R.R., Badizadegan, K., and Feld, M.S. (2006). Optical measurement of cell membrane tension. Phys. Rev. Lett., 97.","DOI":"10.1103\/PhysRevLett.97.218101"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"17001","DOI":"10.1364\/OE.15.017001","article-title":"Microrheology of red blood cell membranes using dynamic scattering microscopy","volume":"15","author":"Amin","year":"2007","journal-title":"Opt. Express"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1364\/BOE.2.000485","article-title":"Effective 3D viscoelasticity of red blood cells measured by diffraction phase microscopy","volume":"2","author":"Wang","year":"2011","journal-title":"Biomed. Opt. Express"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Kim, Y., Higgins, J.M., Dasari, R.R., Suresh, S., and Park, Y.K. (2012). Anisotropic light scattering of individual sickle red blood cells. J. Biomed. Opt., 17.","DOI":"10.1117\/1.JBO.17.4.040501"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.1016\/j.actbio.2012.07.011","article-title":"Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient","volume":"8","author":"Byun","year":"2012","journal-title":"Acta Biomater"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1364\/OL.29.002028","article-title":"Noncontact measurement of nerve displacement during action potential with a dual-beam low-coherence interferometer","volume":"29","author":"Chu","year":"2004","journal-title":"Opt. Lett."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.4049\/jimmunol.0903066","article-title":"Crosstalk between PKA and Epac regulates the phenotypic maturation and function of human dendritic cells","volume":"185","author":"Garay","year":"2010","journal-title":"J. Immunol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"8115","DOI":"10.1364\/OE.15.008115","article-title":"Investigating nanoscale cellular dynamics with cross-sectional spectral domain phase microscopy","volume":"15","author":"Ellerbee","year":"2007","journal-title":"Opt. Express"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"20571","DOI":"10.1364\/OE.19.020571","article-title":"Dispersion-relation phase spectroscopy of intracellular transport","volume":"19","author":"Wang","year":"2011","journal-title":"Opt. Express"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1364\/BOE.1.000260","article-title":"Actin-driven cell dynamics probed by Fourier transform light scattering","volume":"1","author":"Ding","year":"2010","journal-title":"Biomed. Opt. Express"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Pache, C., K\u00fchn, J., Westphal, K., Toy, M.F., Parent, J., B\u00fcchi, O., Franco-Obreg\u00f3n, A., Depeursinge, C., and Egli, M. (2010). Digital holographic microscopy real-time monitoring of cytoarchitectural alterations during simulated microgravity. J. Biomed. Opt., 15.","DOI":"10.1117\/1.3377960"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Pavillon, N., K\u00fchn, J., Moratal, C., Jourdain, P., Depeursinge, C., Magistretti, P.J., and Marquet, P. (2012). Early cell death detection with digital holographic microscopy. PLoS One, 7.","DOI":"10.1371\/journal.pone.0030912"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1364\/BOE.3.000153","article-title":"Measurement of the traction force of biological cells by digital holography","volume":"3","author":"Yu","year":"2012","journal-title":"Biomed. Opt. Express"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1364\/BOE.1.000414","article-title":"Quantitative phase study of the dynamic cellular response in femtosecond laser photoporation","volume":"1","author":"Antkowiak","year":"2010","journal-title":"Biomed. Opt. Express"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"12031","DOI":"10.1364\/OE.17.012031","article-title":"Digital holographic microscopy for quantitative cell dynamic evaluation during laser microsurgery","volume":"17","author":"Yu","year":"2009","journal-title":"Opt. Express"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"17512","DOI":"10.1073\/pnas.0704658104","article-title":"Digital holographic microscopy reveals prey-induced changes in swimming behavior of predatory dinoflagellates","volume":"104","author":"Sheng","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"8051","DOI":"10.1364\/OE.19.008051","article-title":"Measuring translational, rotational, and vibrational dynamics in colloids with digital holographic microscopy","volume":"19","author":"Fung","year":"2011","journal-title":"Opt. Express"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.tibtech.2011.08.004","article-title":"Optical imaging techniques for the study of malaria","volume":"30","author":"Cho","year":"2011","journal-title":"Trends Biotechnol"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/srep00614","article-title":"Pf155\/RESA protein influences the dynamic microcirculatory behavior of ring-stage Plasmodium falciparum infected red blood cells","volume":"2","author":"Park","year":"2012","journal-title":"Sci. Rep."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Lee, S., Kim, Y.R., Lee, J.Y., Rhee, J.H., Park, C.-S., and Kim, D.Y. (2011). Dynamic analysis of pathogen-infected host cells using quantitative phase microscopy. J. Biomed. Opt., 16.","DOI":"10.1117\/1.3548882"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1160\/TH10-02-0140","article-title":"Differential cytotoxic actions of Shiga toxin 1 and Shiga toxin 2 on microvascular and macrovascular endothelial cells","volume":"105","author":"Bauwens","year":"2011","journal-title":"Thromb. Haemost."},{"key":"ref_129","first-page":"101","article-title":"Label-free cytotoxicity screening assay by digital holographic microscopy","volume":"11","author":"Shaffer","year":"2012","journal-title":"Assay Drug Dev. Technol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev-bioeng-070909-105339","article-title":"Sickle cell biomechanics","volume":"12","author":"Barabino","year":"2010","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Shaked, N.T., Satterwhite, L.L., Telen, M.J., Truskey, G.A., and Wax, A. (2011). Quantitative microscopy and nanoscopy of sickle red blood cells performed by wide field digital interferometry. J. Biomed. Opt., 16.","DOI":"10.1117\/1.3556717"},{"key":"ref_132","first-page":"72","article-title":"Optical quantification of cellular mass, volume, and density of circulating tumor cells identified in an ovarian cancer patient","volume":"2","author":"Phillips","year":"2012","journal-title":"Front. Oncol."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Kemper, B., Carl, D., Schnekenburger, J., Bredebusch, I., Sch\u00e4fer, M., Domschke, W., and von Bally, G. (2006). Investigation of living pancreas tumor cells by digital holographic microscopy. J. Biomed. Opt., 11.","DOI":"10.1117\/1.2204609"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1039\/c003477k","article-title":"Lensfree microscopy on a cellphone","volume":"10","author":"Tseng","year":"2010","journal-title":"Lab Chip"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Alexandrov, S., Hillman, T., Gutzler, T., and Sampson, D. (2006). Synthetic aperture Fourier holographic optical microscopy. Phys. Rev. Lett., 97.","DOI":"10.1103\/PhysRevLett.97.168102"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nphoton.2012.329","article-title":"Marker-free phase nanoscopy","volume":"7","author":"Cotte","year":"2013","journal-title":"Nat. Photonics"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.cell.2010.12.002","article-title":"Breaking the diffraction barrier: Super-resolution imaging of cells","volume":"143","author":"Huang","year":"2010","journal-title":"Cell"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Cho, S., Jang, J., Song, C., Lee, H., Ganesan, P., Yoon, T.-Y., Kim, M.W., Choi, M.C., Ihee, H., and Do, H.W. (2013). Simple super-resolution live-cell imaging based on diffusion-assisted Forster resonance energy transfer. Sci. Rep., 3.","DOI":"10.1038\/srep01208"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nphoton.2012.88","article-title":"Controlling waves in space and time for imaging and focusing in complex media","volume":"6","author":"Mosk","year":"2012","journal-title":"Nat. Photonics"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1364\/OE.21.002890","article-title":"Complex wavefront shaping for optimal depth-selective focusing in optical coherence tomography","volume":"21","author":"Jang","year":"2013","journal-title":"Opt. Express"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1364\/OL.32.002309","article-title":"Focusing coherent light through opaque strongly scattering media","volume":"32","author":"Vellekoop","year":"2007","journal-title":"Opt. Lett."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Aulbach, J., Gjonaj, B., Johnson, P.M., Mosk, A.P., and Lagendijk, A. (2011). Control of light transmission through opaque scattering media in space and time. Phys. Rev. Lett., 106.","DOI":"10.1103\/PhysRevLett.106.103901"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1364\/OL.37.003261","article-title":"Active spectral filtering through turbid media","volume":"37","author":"Park","year":"2012","journal-title":"Opt. Lett."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"17010","DOI":"10.1364\/OE.20.017010","article-title":"Dynamic active wave plate using random nanoparticles","volume":"20","author":"Park","year":"2012","journal-title":"Opt. Express"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1038\/nmeth.2219","article-title":"Phase gradient microscopy in thick tissue with oblique back-illumination","volume":"9","author":"Ford","year":"2012","journal-title":"Nature Methods"}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/13\/4\/4170\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:45:50Z","timestamp":1760219150000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/13\/4\/4170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,28]]},"references-count":145,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4]]}},"alternative-id":["s130404170"],"URL":"https:\/\/doi.org\/10.3390\/s130404170","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,28]]}}}