{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:13:52Z","timestamp":1775196832277,"version":"3.50.1"},"reference-count":29,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2013,4,11]],"date-time":"2013-04-11T00:00:00Z","timestamp":1365638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>The development and optimization of new biosensors with horseradish peroxidase immobilized in carbon nanotubes-polyethyleneimine or polypyrrole nanocomposite film at the surface of two types of transducer is described. The amperometric detection of acetaminophen was carried out at \u22120.2 V versus Ag\/AgCl using carbon  based-screen printed electrodes (SPEs) and glassy carbon electrodes (GCEs) as transducers. The electroanalytical parameters of the biosensors are highly dependent on their configuration and on the dimensions of the carbon nanotubes. The best limit of detection obtained for acetaminophen was 1.36 \u00b1 0.013 \u03bcM and the linear range 9.99\u201379.01 \u03bcM for the HRP-SWCNT\/PEI in GCE configuration. The biosensors were successfully applied for the detection of acetaminophen in several drug formulations.<\/jats:p>","DOI":"10.3390\/s130404841","type":"journal-article","created":{"date-parts":[[2013,4,11]],"date-time":"2013-04-11T12:00:21Z","timestamp":1365681621000},"page":"4841-4854","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Carbon Based Electrodes Modified with Horseradish  Peroxidase Immobilized in Conducting Polymers for Acetaminophen Analysis"],"prefix":"10.3390","volume":"13","author":[{"given":"Mihaela","family":"Tertis","sequence":"first","affiliation":[{"name":"Analytical Chemistry Department, Faculty of Pharmacy, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 4 Pasteur St., Cluj-Napoca 400349, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anca","family":"Florea","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Department, Faculty of Pharmacy, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 4 Pasteur St., Cluj-Napoca 400349, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Sandulescu","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Department, Faculty of Pharmacy, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 4 Pasteur St., Cluj-Napoca 400349, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4158-3324","authenticated-orcid":false,"given":"Cecilia","family":"Cristea","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Department, Faculty of Pharmacy, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 4 Pasteur St., Cluj-Napoca 400349, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2013,4,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.trac.2005.03.019","article-title":"New materials for electrochemical sensing VI: Carbon nanotubes","volume":"24","author":"Merkoc","year":"2005","journal-title":"Trends Anal. 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