{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:43:42Z","timestamp":1778273022896,"version":"3.51.4"},"reference-count":167,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T00:00:00Z","timestamp":1371168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Recent advances in biosensor design and sensing efficacy need to be amalgamated with research in responsive drug delivery systems for building superior health or illness regimes and ensuring good patient compliance. A variety of illnesses require continuous monitoring in order to have efficient illness intervention. Physicochemical changes in the body can signify the occurrence of an illness before it manifests. Even with the usage of sensors that allow diagnosis and prognosis of the illness, medical intervention still has its downfalls. Late detection of illness can reduce the efficacy of therapeutics. Furthermore, the conventional modes of treatment can cause side-effects such as tissue damage (chemotherapy and rhabdomyolysis) and induce other forms of illness (hepatotoxicity). The use of drug delivery systems enables the lowering of side-effects with subsequent improvement in patient compliance. Chronic illnesses require continuous monitoring and medical intervention for efficient treatment to be achieved. Therefore, designing a responsive system that will reciprocate to the physicochemical changes may offer superior therapeutic activity. In this respect, integration of biosensors and drug delivery is a proficient approach and requires designing an implantable system that has a closed loop system. This offers regulation of the changes by means of releasing a therapeutic agent whenever illness biomarkers prevail. Proper selection of biomarkers is vital as this is key for diagnosis and a stimulation factor for responsive drug delivery. By detecting an illness before it manifests by means of biomarkers levels, therapeutic dosing would relate to the severity of such changes. In this review various biosensors and drug delivery systems are discussed in order to assess the challenges and future perspectives of integrating biosensors and drug delivery systems for detection and management of chronic illness.<\/jats:p>","DOI":"10.3390\/s130607680","type":"journal-article","created":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T11:47:47Z","timestamp":1371210467000},"page":"7680-7713","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Integration of Biosensors and Drug Delivery Technologies for Early Detection and Chronic Management of Illness"],"prefix":"10.3390","volume":"13","author":[{"given":"Mpho","family":"Ngoepe","sequence":"first","affiliation":[{"name":"Department of Pharmacy and Pharmacology, Faculty of Health Sciences,  University of the Witwatersrand, 7 York Road, Parktown, 2193, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3889-1529","authenticated-orcid":false,"given":"Yahya","family":"Choonara","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmacology, Faculty of Health Sciences,  University of the Witwatersrand, 7 York Road, Parktown, 2193, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charu","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmacology, Faculty of Health Sciences,  University of the Witwatersrand, 7 York Road, Parktown, 2193, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lomas","family":"Tomar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmacology, Faculty of Health Sciences,  University of the Witwatersrand, 7 York Road, Parktown, 2193, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Du Toit","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmacology, Faculty of Health Sciences,  University of the Witwatersrand, 7 York Road, Parktown, 2193, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8640-4350","authenticated-orcid":false,"given":"Pradeep","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmacology, Faculty of Health Sciences,  University of the Witwatersrand, 7 York Road, Parktown, 2193, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valence","family":"Ndesendo","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences, St. John's University of Tanzania, Dodoma, Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8119-3347","authenticated-orcid":false,"given":"Viness","family":"Pillay","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmacology, Faculty of Health Sciences,  University of the Witwatersrand, 7 York Road, Parktown, 2193, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2013,6,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1016\/j.biomaterials.2009.12.052","article-title":"Electroconductive hydrogels: Synthesis, characterization and biomedical applications","volume":"31","year":"2010","journal-title":"Biomaterials"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.sab.2007.11.027","article-title":"Nanosensing at the single cell level","volume":"63","year":"2008","journal-title":"Spectrochim. Acta Part B"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0956-5663(94)80127-4","article-title":"Transducer aspects of biosensors","volume":"9","author":"Sethi","year":"1994","journal-title":"Biosens. Bioelectron."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1177\/009127000004001212","article-title":"Optimizing the use of biomarkers, surrogate endpoints, and clinical endpoints for more efficient drug development","volume":"40","author":"Colburn","year":"2000","journal-title":"J. Clin. Pharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S0956-5663(03)00086-1","article-title":"Lung cancer identification by means of analysis of breath by means of an array of non-selective gas sensors","volume":"18","author":"Macagnano","year":"2003","journal-title":"Biosens. Bioelectron."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1164\/rccm.200409-1184OC","article-title":"Detection of lung cancer by sensor array analyses of exhaled breath","volume":"171","author":"Machado","year":"2005","journal-title":"Amer. J. Respir. Crit. Care Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/S0140-6736(98)07552-7","article-title":"Volatile organic compounds in breathe as markers of lung cancer: A cross-sectional study","volume":"353","author":"Phillips","year":"1999","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10549-006-9176-1","article-title":"Prediction of breast cancer using volatile biomarkers in the breath","volume":"99","author":"Phillips","year":"2006","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1161\/CIRCULATIONAHA.104.482570","article-title":"Biomarkers of cardiovascular illness: Molecular basis and practical consideration","volume":"113","author":"Vasan","year":"2006","journal-title":"Circulation"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.tips.2010.01.003","article-title":"Emerging applications of nanomedicine for the diagnosis and treatment of cardiovascular illnesses","volume":"31","author":"Godin","year":"2010","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1371\/journal.pmed.0030428","article-title":"Illness biomarkers in cerebrospinal fluid of patient with first-onset psychosis","volume":"3","author":"Huang","year":"2006","journal-title":"PLoS Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"313","DOI":"10.14219\/jada.archive.2006.0180","article-title":"Salivary diagnostic powered by nanotechnologies, proteomics and genomics","volume":"137","author":"Wong","year":"2006","journal-title":"J. Amer. Dent. Assoc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.microc.2004.10.008","article-title":"Breath analysis: Trends in techniques and clinical applications","volume":"79","author":"Di","year":"2005","journal-title":"Microchem. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1093\/clinchem\/47.6.1053","article-title":"Analysis of volatile illness markers in blood","volume":"47","author":"Miekisch","year":"2001","journal-title":"Clin. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1158\/1078-0432.CCR-05-2563","article-title":"Ovarian cancer biomarkers in urine","volume":"12","author":"Chambers","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.bios.2008.07.051","article-title":"Early determination of cystic fibrosis by electrochemical chloride quantification in sweat","volume":"24","author":"Mas","year":"2009","journal-title":"Biosens. Bioelectron."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.3390\/s8031366","article-title":"Assembling amperometric biosensors for clinical diagnostics","volume":"8","author":"Belluzo","year":"2008","journal-title":"Sensors"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1136\/thorax.55.3.205","article-title":"Exhaled 8-isoprostane as a new non-invasive biomarker of oxidative stress in cystic fibrosis","volume":"55","author":"Montuschi","year":"2000","journal-title":"Thorax"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1586\/14789450.4.4.531","article-title":"Human saliva proteome analysis and disease biomarker discovery","volume":"4","author":"Hu","year":"2007","journal-title":"Expert Rev. Proteomics"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.1016\/j.electacta.2009.03.008","article-title":"Smart electrochemical biosensors: From advanced materials to ultrasensitive devices","volume":"55","author":"Sadik","year":"2010","journal-title":"Electrochim. Acta"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1164\/ajrccm.158.3.9710031","article-title":"Elevated levels of expired breath hydrogen peroxide in bronchiectasis","volume":"158","author":"Loukides","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1164\/rccm.200210-1253OC","article-title":"Aldehydes in exhaled breath condensate of patients with chronic obstructive pulmonary illness","volume":"167","author":"Corradi","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1088\/1752-7155\/3\/4\/046002","article-title":"A chemometric study on human breath mass spectra for biomarker identification in cystic fibrosis","volume":"3","author":"Bennett","year":"2009","journal-title":"J. Breath Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1183\/09031936.00142508","article-title":"Exhaled biomarkers in lung cancer","volume":"34","author":"Horvath","year":"2009","journal-title":"Eur. Respir. J."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Kwon, G.S. (2005). Polymeric Drug Delivery Systems (Drugs and the Pharmaceutical Sciences), Taylor & Francis.","DOI":"10.1201\/9780849348129"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1023\/A:1011494008729","article-title":"Design of a self-regulated drug delivery device","volume":"3","author":"Cao","year":"2001","journal-title":"Biomed. Microdevices"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Kwon, G.S. (2005). Polymeric Drug Delivery Systems, Taylor & Francis group. Chapter 6.","DOI":"10.1201\/9780849348129"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S0169-409X(02)00090-X","article-title":"Implantable, polymeric systems for modulated drug delivery","volume":"54","author":"Sershen","year":"2002","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1021\/cr068123a","article-title":"Electrochemical glucose biosensors","volume":"108","author":"Wang","year":"2008","journal-title":"Chem. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"5996","DOI":"10.3390\/s120505996","article-title":"A critical review of glucose biosensors based on carbon nanomaterials: Carbon nanotubes and grapheme","volume":"12","author":"Zhu","year":"2012","journal-title":"Sensors"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1749-6632.1962.tb13623.x","article-title":"Electrode systems for continuous monitoring in cardiovascular surgery","volume":"102","author":"Clark","year":"1962","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0003-2670(74)80021-8","article-title":"Amperometric enzyme electrode: Part II. Amino acid oxidase","volume":"69","author":"Guilbault","year":"1974","journal-title":"Anal. Chim. Acta"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.preteyeres.2011.05.002","article-title":"Inflammation in diabetic retinopathy","volume":"30","author":"Tang","year":"2011","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/09674845.2012.12002443","article-title":"A history of blood glucose meters and their self-monitoring of diabetes mellitus","volume":"69","author":"Clarke","year":"2012","journal-title":"Br. J. Biomed. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0168-8227(06)70007-9","article-title":"Continuous glucose monitoring: Key challenges to replacing episodic SMBG","volume":"74","author":"Stout","year":"2006","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1046\/j.1365-2796.1997.112133000.x","article-title":"The problem of compliance to cholesterol altering therapy","volume":"241","author":"Insull","year":"1997","journal-title":"J. Intern Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.enzmictec.2006.04.007","article-title":"Amperometric enzyme electrode for free cholesterol determination prepared with cholesterol oxidase immobilized in poly(vinylferrocenium) film","volume":"40","author":"Celebi","year":"2007","journal-title":"Enzyme Microb. Technol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.3390\/s100201216","article-title":"ZnO based amperometric enzyme biosensor","volume":"10","author":"Zhao","year":"2010","journal-title":"Sensors"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.aca.2005.10.008","article-title":"Covalent immobilization of cholesterol esterase and cholesterol oxidase on polyaniline fils for application to cholesterol biosensor","volume":"568","author":"Singh","year":"2006","journal-title":"Anal. Chim. Acta"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/BF02535990","article-title":"Effect of regulation cholesterol biosynthesis on breath isoprene excretion in men","volume":"28","author":"Stone","year":"1993","journal-title":"Lipids"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1088\/0967-3334\/25\/3\/R01","article-title":"Reverse iontophoresis for non-invasive transdermal monitoring","volume":"25","author":"Leboulanger","year":"2004","journal-title":"Physiol. Meas."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1089\/dia.2005.7.174","article-title":"Noninvasive and minimally invasive methods for transdermal glucose monitoring","volume":"7","author":"Sieg","year":"2005","journal-title":"Diabetes Technol. Ther."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1464-5491.2008.02642.x","article-title":"Glucose sensors: A review of current and emerging technology","volume":"26","author":"Oliver","year":"2008","journal-title":"Diabet. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0003-2670(03)00531-2","article-title":"Polyacrylamide gels with electrostatic functional groups for the imprinting of lysozyme","volume":"504","author":"Ou","year":"2004","journal-title":"Anal. Chim. Acta"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0956-5663(99)00039-1","article-title":"Biosensor for detection of pathogenic bacteria","volume":"14","author":"Ivnitski","year":"1999","journal-title":"Biosens. Bioelectron."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.3390\/s100403882","article-title":"Metal oxide sensors for electronic noses and their application to food analysis","volume":"10","author":"Berna","year":"2010","journal-title":"Sensors"},{"key":"ref_47","first-page":"121","article-title":"Electrochemical biosensor: Recommended definitions and classification","volume":"16","author":"Toth","year":"2001","journal-title":"Biosens. Bioelectron."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0165-9936(95)91618-3","article-title":"Antibodies: Production, function and application in biosensors","volume":"14","author":"Killard","year":"1995","journal-title":"Trends Analyt. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.3390\/s90604407","article-title":"Antibody-based sensors: Principles, problems and potential for detection of pathogens and associated toxins","volume":"9","author":"Byrne","year":"2009","journal-title":"Sensors"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0003-2670(99)00889-2","article-title":"Amperometric enzyme immunosensor for the determination of the antigen of the pathogenic fungi","volume":"411","author":"Medyantseva","year":"2000","journal-title":"Trichophy. Rubrum. Anal. Chim. Acta"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10544-006-9026-2","article-title":"Design and testing of a disposable microfluidic chemiluminescent immunoassay for illness biomarkers in human serum samples","volume":"9","author":"Bhattacharyya","year":"2007","journal-title":"Biomed. Microdevices"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1016\/j.bios.2006.08.043","article-title":"Flexible biosensors on spirally rolled micro tube for cardiovascular in vivo monitoring","volume":"22","author":"Li","year":"2007","journal-title":"Biosens. Bioelectron."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.tibtech.2005.01.004","article-title":"Physicochemical perspectives on DNA microarray and biosensor technologies","volume":"23","author":"Levicky","year":"2005","journal-title":"Trends Biotechnol."},{"key":"ref_54","unstructured":"Shan, G., Lipton, C., Gee, S.R., and Hammock, B.D. (2002). Immunoassay, Biosensors and other Non-chromatographic Methods. Handbook of Residue Analytical Methods for Agrochemicals, John Wiley and Sons, Ltd."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.3390\/s90705149","article-title":"Optical biosensor based on semiconductor nanostructures","volume":"9","author":"Manso","year":"2009","journal-title":"Sensors"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1039\/b714449k","article-title":"Electrochemical biosensors","volume":"39","author":"Ronkainen","year":"2010","journal-title":"Chem. Soc. Rev."},{"key":"ref_57","first-page":"1","article-title":"biological application of surface Plasmon resonance biosensors (review)","volume":"12","author":"Ramanavieius","year":"2005","journal-title":"Acta Med. Litu."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.3390\/s100302045","article-title":"Signal amplification by enzymatic reaction in an immunosensors based on localized surface Plasmon resonance (LSPR)","volume":"10","author":"Lee","year":"2010","journal-title":"Sensors"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0956-5663(03)00215-X","article-title":"Development of a novel FRET immunosensor technique","volume":"30","author":"Lichlyter","year":"2003","journal-title":"Biosens. Bioelectron."},{"key":"ref_60","first-page":"152","article-title":"Stepwise formation approach to improve ellipsometric biosensor response","volume":"5","author":"Sayar","year":"2009","journal-title":"Nanomedicine Nanotechnol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"8709","DOI":"10.3390\/s91108709","article-title":"The detection of alkaline phosphatase using electrochemical biosensor in a single-step approach","volume":"9","author":"Wang","year":"2009","journal-title":"Sensors"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1007\/s00216-008-1911-5","article-title":"Surface acoustic wave biosensors: A review","volume":"391","author":"Lange","year":"2008","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0956-5663(99)00040-8","article-title":"Commercial quartz crystal microbalances-theory and applications","volume":"14","author":"Guilbault","year":"1999","journal-title":"Biosens. Bioelectron."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"5859","DOI":"10.3390\/s100605859","article-title":"Development of a quartz crystal microbalance biosensor with aptamers as bio-recognition element","volume":"10","author":"Yao","year":"2010","journal-title":"Sensors"},{"key":"ref_65","first-page":"320","article-title":"Cantilever biosensor","volume":"23","author":"Frometa","year":"2006","journal-title":"Biotecnol. Apl."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1021\/ac0485278","article-title":"Electrochemical immunosensors for the simultaneous detection of two tumor markers","volume":"77","author":"Wilson","year":"2005","journal-title":"Anal. Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.3390\/s80314000","article-title":"Electrochemical biosensors-sensor principles and architectures","volume":"8","author":"Grieshaber","year":"2008","journal-title":"Sensors"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.2337\/dc06-1602","article-title":"Accuracy of the 5-day FreeStyle navigator continuous glucose monitoring system","volume":"30","author":"Weinstein","year":"2007","journal-title":"Diabet. Care"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.aca.2005.11.057","article-title":"Enzyme biosensor based on ion-selective field transistors","volume":"24","author":"Dzyadevych","year":"2006","journal-title":"Anal. Chim. Acta"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"7111","DOI":"10.3390\/s90907111","article-title":"Ion-sensitive field effect transistor for biological sensing","volume":"9","author":"Lee","year":"2009","journal-title":"Sensors"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"7894","DOI":"10.3390\/s8127894","article-title":"Vesicles for signal amplification in a biosensor for the detection of low antigen concentrations","volume":"8","author":"Grieshaber","year":"2008","journal-title":"Sensors"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.snb.2005.06.017","article-title":"Label-free protein recognition using aptamer-based impedance measurement assay","volume":"114","author":"Cai","year":"2006","journal-title":"Sens. Actuators B Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.3390\/s7123442","article-title":"An overview of label free electrochemical protein sensors","volume":"7","author":"Vestergaard","year":"2007","journal-title":"Sensors"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.bios.2008.07.075","article-title":"A novel reagents amperometric immunosensor based on gold nanoparticles\/TMB\/Nafion-modified electrode","volume":"24","author":"Wu","year":"2009","journal-title":"Biosens. Bioelectron."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1021\/ac902162e","article-title":"Amperometric immunosensors for carcinoembryonic antigen in colon cancer samples based on monolayers of dentritic bipodal scaffolds","volume":"82","author":"Laboria","year":"2010","journal-title":"Anal. Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1590\/S0104-66322009000200001","article-title":"The evolution and development of immunosensors for health and environmental monitoring: Problems and perspectives","volume":"26","author":"Ramirez","year":"2009","journal-title":"Braz. J. Chem. Eng."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nmeth.1221","article-title":"Whispering-gallery-mode biosensing: Label-free detection down to single molecules","volume":"7","author":"Vollmer","year":"2008","journal-title":"Nat. Methods"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"14587","DOI":"10.1073\/pnas.0504917102","article-title":"A label free immunosensor array using single-chain antibody fragments","volume":"102","author":"Backmann","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"10817","DOI":"10.1021\/la801295c","article-title":"Effect of solution concentration, surface bias and protonation on the dynamic response of amplitude-modulated atomic force microscopy in water","volume":"24","author":"Wu","year":"2008","journal-title":"Langmuir"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1039\/b908503n","article-title":"Microcantiliver-based platforms as biosensing tools","volume":"135","author":"Alvarez","year":"2010","journal-title":"Analyst"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.bios.2011.07.063","article-title":"A label-free immunosensor based on modified mesoporous silica for simultaneous determination of tumor markers","volume":"29","author":"Lin","year":"2011","journal-title":"Biosens. Bioelectron."},{"key":"ref_82","first-page":"1","article-title":"Bioluminescent bioreporter assays for targeted detection of chemical and biological agents","volume":"6945","author":"Ripp","year":"2008","journal-title":"Proc SPIE"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1021\/cr990003y","article-title":"Enzyme-based biosensors for in vivo measurements","volume":"100","author":"Wilson","year":"2000","journal-title":"Chem. Rev."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"7053","DOI":"10.1021\/ja00069a001","article-title":"Intramolecular electron-transfer rates in ferrocene-derivatized glucose oxidase","volume":"115","author":"Badia","year":"1993","journal-title":"J. Am. Chem. Soc."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1021\/bc00029a009","article-title":"Targeting glucose oxidase at aspartate and glutamate residues with organic two-electron redox mediator","volume":"5","author":"Battaglini","year":"1994","journal-title":"Bioconjugate Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0956-5663(01)00313-X","article-title":"Mediated biosensors","volume":"17","author":"Chaubey","year":"2002","journal-title":"Biosens. Bioelectron."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/1521-4109(200202)14:4<241::AID-ELAN241>3.0.CO;2-P","article-title":"Enzyme based amperometric biosensors for food analysis","volume":"14","author":"Prodromidis","year":"2002","journal-title":"Electroanalysis"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1039\/c1nr10411j","article-title":"Multilayer enzyme-coupled magnetic nanoparticles as efficient, reusable biocatalysts and biosensors","volume":"3","author":"Garcia","year":"2011","journal-title":"Nanoscale"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.3390\/s100504558","article-title":"Glucose biosensors: An overview of use in clinical practice","volume":"10","author":"Yoo","year":"2010","journal-title":"Sensors"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF03214967","article-title":"Alkaline glucose oxidation on nanostructured gold electrodes","volume":"43","author":"Pasta","year":"2010","journal-title":"Gold Bull."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1002\/elan.200603545","article-title":"Amperometric detection of glucose with glucose oxidase immobilized in layered double hydroxides","volume":"18","author":"Shan","year":"2006","journal-title":"Electroanalysis"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1109\/JMEMS.2008.916357","article-title":"A MEMS thermal biosensor for metabolic monitoring applications","volume":"17","author":"Wang","year":"2008","journal-title":"J. Microelectroch. Syst."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jelechem.2003.12.022","article-title":"Effect of metal ad-layers on Au (111) electrodes on electrocatalytic oxidation of glucose in an alkaline solution","volume":"567","author":"Aoun","year":"2004","journal-title":"J. Electroanal. Chem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1021\/bi035697q","article-title":"Cholesterol oxidase senses subtle changes in lipid bilayer structure","volume":"43","author":"Ahn","year":"2004","journal-title":"Biochemistry"},{"key":"ref_95","first-page":"667","article-title":"Ferrocene-mediated enzyme electrode for amperometric determination of glucose","volume":"56","author":"Cass","year":"1984","journal-title":"J. Am. Chem. Soc."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1016\/j.bios.2008.12.004","article-title":"Bioelectrochemistry of hemoglobin immobilized on a sodium alginate-multiwall carbon nanotubes composite film","volume":"24","author":"Zhao","year":"2009","journal-title":"Biosens. Bioelectron."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/j.bios.2008.08.055","article-title":"Development of disposable lipid biosensor for the determination of total cholesterol","volume":"24","author":"Shih","year":"2009","journal-title":"Biosens. Bioelectron."},{"key":"ref_98","first-page":"3","article-title":"Optical imaging-guided cancer therapy with fluorescent nanoparticles","volume":"7","author":"Jiang","year":"2010","journal-title":"J. R. Soc."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S1470-2045(06)70584-8","article-title":"Discovery and validation of new protein biomarkers for urothelial cancer: A prospective analysis","volume":"7","author":"Theodorescu","year":"2006","journal-title":"Lancet Oncol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2174\/157016309787581066","article-title":"Development of multifunctional nanoparticles for targeted drug delivery invasive imaging of therapeutic effect","volume":"6","author":"Sijja","year":"2009","journal-title":"Curr. Drug Discov. Technol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.addr.2007.08.029","article-title":"Cell based drug delivery","volume":"60","author":"Pierige","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1021\/ac0313217","article-title":"Responsive drug delivery system","volume":"75","author":"Deo","year":"2003","journal-title":"Anal. Chem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1016\/S0013-4686(00)00329-7","article-title":"Electron and proton conducting polymers: Recent developments and prospects","volume":"45","author":"Inzelt","year":"2000","journal-title":"Electrochim. Acta"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.snb.2010.03.083","article-title":"Hydrogel-based devices for biomedical applications","volume":"147","author":"Deligkaris","year":"2010","journal-title":"Sens. Actuators B Chem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1002\/(SICI)1097-4628(20000613)76:11<1637::AID-APP4>3.0.CO;2-Q","article-title":"Chitosan microspheres and sponges: Preparation and characterization","volume":"76","author":"Denkbas","year":"2000","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.tips.2009.08.004","article-title":"Liposome and nanoparticles: Nanosized vehicles for drug delivery in cancer","volume":"30","author":"Malam","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_107","first-page":"173","article-title":"Supramoleucular hydrogels","volume":"12","author":"Maity","year":"2008","journal-title":"JPS"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/j.polymer.2008.01.027","article-title":"Hydrogel in drug delivery: Progress and challenges","volume":"49","author":"Hoare","year":"2008","journal-title":"Polymers"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.progpolymsci.2004.05.002","article-title":"Grafting: Versatile means of modifying polymers techniques, factors and apllications","volume":"29","author":"Bhattacharya","year":"2004","journal-title":"Prog. Polym. Sci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/j.bios.2009.12.022","article-title":"Gold nanoparticle based colorimetric assay for cancer diagnosis","volume":"25","author":"Kang","year":"2010","journal-title":"Biosens. Bioelectron"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.bioeng.2006.05.026","article-title":"The pinpoint promise of nanoparticle based drug delivery and molecular diagnosis","volume":"23","author":"Emerich","year":"2006","journal-title":"Biomol. Eng"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-3659(00)00339-4","article-title":"Biodegradable polymeric nanoparticles as drug delivery devices","volume":"70","author":"Soppimath","year":"2001","journal-title":"J. Controlled Release"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1039\/b410943k","article-title":"Biomedical applciations of functionalized carbon nanotubes","volume":"7","author":"Bianco","year":"2005","journal-title":"Chem. Commun."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1109\/JMEMS.2002.803281","article-title":"Equilibrium swelling and kinetics of pH responsive hydrogels: Models, experiments and simulations","volume":"11","author":"De","year":"2002","journal-title":"J. Microelectromech. Syst."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0167-7799(02)01962-5","article-title":"Lessons from nature: Stimuli-responsive polymers and their biomedical applications","volume":"20","author":"Jeong","year":"2002","journal-title":"Trends Biotechnol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.snb.2006.07.022","article-title":"Molecularly imprinted polymer (biomimetic) based potentiometric sensor for atrazine","volume":"123","author":"Prasad","year":"2007","journal-title":"Sens. Actuators B Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/21619","article-title":"A reversibly antigen-responsive hydrogel","volume":"399","author":"Miyata","year":"1999","journal-title":"Nature"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1208\/aapsj080483","article-title":"Optimizing target gene delivery: Chemical modification of viral vectors and synthesis of artificial vector systems","volume":"8","author":"Boeckle","year":"2006","journal-title":"AAPS J."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"5760","DOI":"10.1016\/j.vaccine.2010.06.087","article-title":"; Lubitz. Bacterial ghost (BGs)-advanced antigen and drug delivery system","volume":"28","author":"Kudela","year":"2010","journal-title":"Vaccine"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ejpb.2010.06.007","article-title":"Polymeric micelles for oral drug delivery","volume":"76","author":"Gaucher","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/j.addr.2005.09.018","article-title":"Dendrimers in biomedical applications-reflections on the field","volume":"57","author":"Svenson","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jconrel.2003.11.018","article-title":"Drug, enzyme and peptide delivery using erythrocytes as carriers","volume":"95","author":"Marinero","year":"2004","journal-title":"J. Controlled Release"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1517\/17425247.2.2.311","article-title":"Erythrocyte-based drug delivery","volume":"2","author":"Rossi","year":"2005","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3109\/10717549509031352","article-title":"Red blood cells as a delivery system for AZT","volume":"2","author":"Magnani","year":"1995","journal-title":"Drug Deliv."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0169-409X(02)00229-6","article-title":"Design strategies to improve soluble macromolecular delivery constructs","volume":"55","author":"Christie","year":"2003","journal-title":"Adv. Drug Del. Rev."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.2174\/138161210790963832","article-title":"Peptide-based matrices as drug delivery vehicles","volume":"16","author":"Ezzat","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"ref_127","first-page":"43","article-title":"Drug nanoparticles: Formulating poorly water-soluble compounds toxicologic","volume":"36","author":"Liversidge","year":"2008","journal-title":"Pathology"},{"key":"ref_128","first-page":"295","article-title":"Nanocrystal technology, drug delivery and clinical application","volume":"3","author":"Junghanns","year":"2008","journal-title":"Int. J. Nanomedicine"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.progpolymsci.2004.08.003","article-title":"Stimuli-responsive polymers and their bioconjugates","volume":"29","author":"Gil","year":"2004","journal-title":"Prog. Polym. Sci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"6860","DOI":"10.3390\/s8116860","article-title":"Microsensors for in vivo measurements of glutamate in brain tissue","volume":"8","author":"Qin","year":"2008","journal-title":"Sensors"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1602\/neurorx.2.1.1","article-title":"The blood brain barrier and neurotherapeutics","volume":"2","author":"Pardridge","year":"2005","journal-title":"NeuroRx"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1016\/S0142-9612(03)00161-3","article-title":"Biocompatibility of implantable synthetic polymeric drug carriers: Focus on brain biocompatibility","volume":"24","author":"Fournier","year":"2003","journal-title":"Biomaterials"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1073\/pnas.0409336102","article-title":"Nanoparticle based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's illness","volume":"102","author":"Geoganopoulou","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1602\/neurorx.2.1.3","article-title":"The blood brain barrier: Bottleneck in brain drug delivery development","volume":"2","author":"Pardridge","year":"2005","journal-title":"NeuroRx"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"7266","DOI":"10.3390\/s90907266","article-title":"Semiconductor quantum dots in chemical sensors and biosensors","volume":"9","author":"Frasco","year":"2009","journal-title":"Sensors"},{"key":"ref_136","first-page":"133","article-title":"Drug delivery and nanoparticles: Applications and hazards","volume":"3","author":"Borm","year":"2008","journal-title":"Int. J. Nanomedicine"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1743-8977-7-3","article-title":"Multifunctional nanocarriers for diagnosis, drug delivery and targeted treatment across blood-brain barrier: Perspective on tracking and neuroimaging","volume":"7","author":"Bhaskar","year":"2010","journal-title":"Part Fibre Toxicol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3989\/revmetalm.2003.v39.i1.316","article-title":"Electrical charging of aerosol nanoparticles and some practical applications","volume":"39","author":"Alonso","year":"2003","journal-title":"Rev. Metal Madrid."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ejpb.2003.10.015","article-title":"Effect of cationic lipid and matric lipid compositin on solid lipid Nanoparticle-mediated gene transfer","volume":"57","author":"Tabatt","year":"2004","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.addr.2005.07.006","article-title":"Comparison of the mucoadhesive properties of various polymers","volume":"57","author":"Grabovac","year":"2005","journal-title":"Adv. Drug Del. Rev."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"411","DOI":"10.4155\/tde.10.27","article-title":"Peptides for specific intracellular delivery and targeting of nanoparticles: Implications for developing nanoparticle-mediated drug delivery","volume":"1","author":"Delehanty","year":"2010","journal-title":"Ther. Deliv."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.semcdb.2009.01.015","article-title":"Biosensor for cancer diagnosis","volume":"20","author":"Tothill","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0168-3659(98)00178-3","article-title":"Issues and perspectives on the biocompatibility and immunotoxicity evaluation of implanted controlled release systems","volume":"27","author":"Anderson","year":"1999","journal-title":"J. Control Release"},{"key":"ref_144","first-page":"115","article-title":"An implantable microfabricated drug delivery system","volume":"70","author":"Maloney","year":"2003","journal-title":"Am. Soc. Mech. Eng."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"6077","DOI":"10.3390\/s8096077","article-title":"BioMEMS-Advancing the frontiers of medicine","volume":"8","author":"James","year":"2008","journal-title":"Sensors"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev.bioeng.1.1.401","article-title":"Microfabrication in biology and medicine","volume":"1","author":"Voldman","year":"1999","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1109\/JMEMS.2002.807471","article-title":"A piezoelectric microvalve for compact high-frequency, hug-differential pressure hydraulic micropumping system","volume":"12","author":"Roberts","year":"2003","journal-title":"J. Microelectromecha Syst."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.snb.2007.10.064","article-title":"MEMS-based micropumps in drug delivery and biochemical applications","volume":"130","author":"Nisar","year":"2008","journal-title":"Sens. Actuators B"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ijpharm.2010.03.041","article-title":"Transdermal delivery of insulin using microneedle rollers in vivo","volume":"392","author":"Zhou","year":"2010","journal-title":"Int. J. Pharma"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1109\/MEMB.2008.931014","article-title":"BioMEMS devices for drug delivery","volume":"28","author":"Nuxoll","year":"2009","journal-title":"IEEE Eng. Med. Biol. Mag."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.addr.2012.08.006","article-title":"MEMS-enable implantable drug infusion pumps for laboratory research, preclinical, and clinical applications","volume":"64","author":"Meng","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_152","first-page":"677","article-title":"A PZT insulin pump with a silicon microneedle array for transdermal delivery","volume":"56","author":"Ma","year":"2006","journal-title":"Elec. Comp C"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.sse.2006.03.023","article-title":"BioMEMS for medicine: On-chip cell characterization and implantable microelectrodes","volume":"50","author":"Cheung","year":"2006","journal-title":"Solid-State Electron."},{"key":"ref_154","unstructured":"Tomar, L., Tyagi, C., Lahiri, S.S., and Singh, H. Poly(PEGDMA-MAA) copolymeric micro and nanoparticles for oral insulin delivery. http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pat.v22.12\/issuetoc22."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.progpolymsci.2007.05.003","article-title":"Smart polymers: Physical forms and bioengineering applications","volume":"32","author":"Kumar","year":"2007","journal-title":"Prog. Polym. Sci."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.progpolymsci.2009.10.008","article-title":"Future perspectives and recent advances in stimuli-responsive materials","volume":"35","author":"Roy","year":"2010","journal-title":"Prog. Polym. Sci."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/S0142-9612(00)00050-8","article-title":"Characterization of glucose-sensitive insulin release systems in simulated in vivo conditions","volume":"21","author":"Traitel","year":"2000","journal-title":"Biomaterials"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0003-2697(02)00201-4","article-title":"Easily reversible desthiobiotin binding to streptavidin, avidin, and other biotin-binding proteins: Uses for protein labeling, detection and isolation","volume":"308","author":"Hirsch","year":"2002","journal-title":"Anal. Biochem."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0169-409X(01)00203-4","article-title":"Environment-sensitive hydrogels for drug delivery","volume":"53","author":"Qiu","year":"2001","journal-title":"Adv. Drug Del. Rev."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1109\/JPROC.2003.820534","article-title":"A BioMEMS review: MEMS technology for physiologically integrated devices","volume":"92","author":"Grayson","year":"2004","journal-title":"Proc. IEEE"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1023\/A:1011489907820","article-title":"Bioadhesive microdevices for drug delivery: A feasibility study","volume":"3","author":"Ahmed","year":"2001","journal-title":"Biomed. Microdevices"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1002\/adma.200801770","article-title":"integrating biosensors and drug delivery; a step closer toward scalable responsive drug-delivery systems","volume":"21","author":"Tsai","year":"2009","journal-title":"Adv. Mater."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1109\/JPROC.2003.820548","article-title":"Disposable smart lab on a chip for point of care clinical diagnostics","volume":"94","author":"Ahn","year":"2004","journal-title":"Proc. IEEE"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/16898","article-title":"A controlled-release microchip","volume":"397","author":"Santini","year":"1999","journal-title":"Nature"},{"key":"ref_165","first-page":"1","article-title":"Injecting new ideas into drug delivery systems: A brief review on microchips as controlled drug delivery systems","volume":"1","author":"Shah","year":"2011","journal-title":"IJRPB"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1007\/s11095-006-9906-4","article-title":"Application of micro- and nano-electrochemical devices to drug delivery","volume":"23","author":"Staples","year":"2006","journal-title":"Pharm. Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1023\/B:BMMD.0000042047.83433.96","article-title":"Continous on-chip micropumping for microneedle enhanced delivery","volume":"6","author":"Zahn","year":"2004","journal-title":"Biomed. Microdevices"}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/13\/6\/7680\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:47:21Z","timestamp":1760219241000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/13\/6\/7680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,14]]},"references-count":167,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,6]]}},"alternative-id":["s130607680"],"URL":"https:\/\/doi.org\/10.3390\/s130607680","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,14]]}}}